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Although many attempts have been made to inoculate successfully ,the lower animals with portions of tumors from human beings they 'have in the great majority of cases been without results. In some instances the observers have claimed that they have been successful }rot their statements are, as a rule, not convincing.Carl Lewin 1 discusses this question of transplantation at length and reviews the reports of those who have conducted such experiments. The following is a synopsis of the instances that he considers, separating them into two groups, according as the results of the transplantation were negative or apparently successful.The first to be given are the negative instances.Doutrelepont ~ experimented with the transplantation of human tissue into the lower animals with negative results.BiIlroth 3 attempted to transfer human carcinoma and round cell sarcoma to dogs. No growth was however, obtained either by implantation or by injection into the jugular vein. Lebert and Wyss * injected a sarcoma emulsion into rabbits without any growth taking place. FischP injected rats intraperitoneally, intravenously and subcutaneously with a small cell sarcoma of the upper arm and with a melano-sarcoma of the lymph nodes. The tumors were absorbed without leaving the slightest trace.Duplay and Cazin" and Pawlowsky 7 transplanted sarcomatous tissue with no resulting growth. Roux and Metschnikoff s inoculated portions of a melano-sarcoma into the anterior chamber of the eye, and also beneath the skin of a young chimpanzee, with negative results.

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1. Malaria existed in certain towns of the Canal Zone at the time this work was done to such an extent that over 50 per cent, of the native born and 70 per cent, of the foreign born harbored parasites in their peripheral circulation. 2. This high percentage of infection does not necessarily mean that a corresponding number present febrile symptoms; in fact, many do not. 3. This high percentage of infection is a menace to the health of those who, by reason of their work, may be compelled to remain in such towns, particularly because of the wide distribution of the Anopheles albipes, a mosquito shown to be capable of transmitting malaria. Other anopheles to a lesser extent may also be factors in distributing malaria. 4. The estivo-autumnal malaria is the prevalent type; the Chagrcs fever is, in all probability, a severe