The transferability of blaOXA-23 gene in multidrug-resistant Acinetobacter baumannii isolates from Saudi Arabia and Egypt

Lopes, Bruno Silvester; Al-Agamy, Mohamed H.; Ismail, Muhammad; Shibl, Atef M.; Al‐Qahtani, Ahmed; Al-Ahdal, Mohammed N.; Forbes, Ken J.

doi:10.1016/j.ijmm.2015.07.007

Cited by 35 publications

(31 citation statements)

References 27 publications

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“…10 Therefore, the viable pan drug-resistant A. baumannii recovered from effluent wastewater could be easily spread through the natural water body, which could represent an environmental reservoir of this emerging pathogen. Moreover, since the plasmid-located bla OXA-23-like gene in isolate EF7 may be self-transferable, 19 the effluent wastewater represents a potential epidemiological reservoir of the carbapenem resistance gene. The impact of secondary treated municipal wastewaters on the occurrence of communityacquired A. baumannii infections outside the hospital environment should be further investigated.…”

Section: Resultsmentioning

confidence: 99%

Pan Drug-Resistant Environmental Isolate of Acinetobacter baumannii from Croatia

Goić-Barišić

Musić

Kovačić

et al. 2017

Microbial Drug Resistance

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Acinetobacter baumannii is an emerging nosocomial pathogen with also emerging resistance to different antibiotics. Multidrug and pan drug-resistant clinical isolates were reported worldwide. Here we report the first evidence of pan drug-resistant environmental isolate of A. baumannii. The isolate was recovered from the effluent of secondary treated municipal wastewater of the City of Zagreb, Croatia. The isolate was resistant to penicillins/β-lactamase inhibitors, carbapenems, fluoroquinolones, aminoglycosides, folate pathway inhibitors, and polymyxins, except intermediately susceptible to minocycline and tigecycline. Intrinsic chromosomally located bla gene and acquired plasmid-located bla gene were related to clinical isolates. Pan drug-resistant A. baumannii can occur in natural environments outside of the hospital. Secondary treated municipal wastewater represents a potential epidemiological reservoir of pan drug-resistant A. baumannii and carbapenem resistance gene.

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Section: Resultsmentioning

confidence: 99%

Pan Drug-Resistant Environmental Isolate of Acinetobacter baumannii from Croatia

Goić-Barišić

Musić

Kovačić

et al. 2017

Microbial Drug Resistance

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“…Both harbored the acquired plasmid-located bla OXA-23 genes closely related to those found in clinical isolates. While the intrinsic chromosomally encoded carbapenem-resistance genes bla OXA-51-like are of low epidemiological relevance, the plasmid-located bla OXA-23 genes may be self-transferable, 27 which raises public health concern.…”

Section: Discussionmentioning

confidence: 99%

Carbapenem-Resistant Acinetobacter baumannii Recovered from Swine Manure

Hrenović

Musić

Durn

et al. 2019

Microbial Drug Resistance

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Recently, concerns have been raised about the possibility of Acinetobacter baumannii transmission between animals and humans. So far, A. baumannii has been reported in animals with which people can come into contact. The presence of this pathogen in animal manure presents an equally important public health risk. In this study, we report the finding of two A. baumannii isolates in swine manure from a Croatian pig farm. Both isolates shared features with the widespread human clinical isolates: affiliation to the international clonal lineage 2 (ST-195), carbapenem, and extensive drug resistance and the plasmid-located acquired bla OXA-23 gene. These two A. baumannii isolates survived anaerobic conditions, competition with other microorganisms, and elevated concentrations of heavy metals in the stagnant swine manure for at least 2 weeks. These findings call for bacteriological analysis and disinfection of liquid swine manure before its application as a fertilizer in traditional extensive agriculture.

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“…Carbapenem-resistant Acinetobacter spp. have been described from many parts of the world, and Saudi Arabia is not an exception [ 15 ]. These authors examined 64 Acinetobacter baumannii isolates during 2013 and 2014 from four different medical centers in Saudi Arabia and Egypt.…”

Section: Discussionmentioning

confidence: 99%

Multidrug-ResistantAcinetobacter baumannii: An Emerging Health Threat in Aseer Region, Kingdom of Saudi Arabia

Almaghrabi

Joseph

Assiry

et al. 2018

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Objective The study aims to determine the prevalence of multidrug-resistant A. baumannii in Aseer Region, Kingdom of Saudi Arabia. Methods This study evaluated the antibiotic susceptibility of ninety-four (n = 94) clinical isolates of A. baumannii. The isolates were collected from the south region of Saudi Arabia, and notably Aseer Region, during the period from 15 October 2014 to 15 January 2015. The isolates were tentatively identified as A. baumannii by routine bench tests and were confirmed by using VITEK® 2 Compact. The latest instrument was used to identify antibiotic susceptibility of these isolates. Results Antibiotic susceptibility in this study showed that 69% of these isolates were multidrug-resistant strains. Moreover, they were highly resistant to carbapenem drugs. Several strains of these isolates were found to be extremely resistant to test antibiotics and were only sensitive to one or two of them. Conclusion High rate of multidrug-resistant A. baumannii bacteraemia has emerged in the south region of Saudi Arabia as an important health problem. Therefore, it is considered as a new threat in hospitals, which requires a tremendous effort to stop its escalation and spread.

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The transferability of blaOXA-23 gene in multidrug-resistant Acinetobacter baumannii isolates from Saudi Arabia and Egypt

Cited by 35 publications

References 27 publications

Pan Drug-Resistant Environmental Isolate of Acinetobacter baumannii from Croatia

Pan Drug-Resistant Environmental Isolate of Acinetobacter baumannii from Croatia

Carbapenem-Resistant Acinetobacter baumannii Recovered from Swine Manure

Multidrug-ResistantAcinetobacter baumannii: An Emerging Health Threat in Aseer Region, Kingdom of Saudi Arabia

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