Carbapenem-Resistant <i>Acinetobacter baumannii</i> Recovered from Swine Manure

Hrenović, Jasna; Musić, Martina Šeruga; Durn, Goran; Dekić, Svjetlana; Hunjak, Blaženka; Kisić, Ivica

doi:10.1089/mdr.2018.0087

Cited by 15 publications

(10 citation statements)

References 28 publications

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“…Recently concerns have also been raised about the possibility of transmission of multiresistant A. baumannii between animals and humans. The occurrence of this pathogen in livestock represents a further notable risk of transmission to humans and further into hospitals [32,33]. The capability of A. baumannii to survive harsh conditions, including disinfection, fosters its persistence in hospital environments.…”

Section: Discussionmentioning

confidence: 99%

“…ST195, which is dominant in Austria, is also the most frequent ST in Croatia, a country with a lot of students and personal exchange with Austria. Notably, A. baumannii isolates with ST195 have also recently been detected in two isolates in a Croatian pig farm [32], from Austria, as a country with intensive animal husbandry, up to now, no cases have yet been reported. OXA-72 is the dominant CHDL in all geographic regions of Croatia in contrast to Austria in which OXA-58 predominates [42,50].…”

Section: Discussionmentioning

confidence: 99%

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Diversity of Oxacillinases and Sequence Types in Carbapenem-Resistant Acinetobacter baumannii from Austria

Grisold¹,

Luxner²,

Bedenić

et al. 2021

IJERPH

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Carbapenem-resistant Acinetobacter baumannii is a significant health problem worldwide. A multicenter study on A. baumannii was performed to investigate the molecular epidemiology and genetic background of carbapenem resistance of A. baumannii isolates collected from 2014–2017 in Austria. In total, 117 non-repetitive Acinetobacter spp. assigned to A. baumannii (n = 114) and A. pittii (n = 3) were collected from four centers in Austria. The isolates were uniformly resistant to piperacillin/tazobactam, ceftazidime, and carbapenems, and resistance to imipenem and meropenem was 97.4% and 98.2%, respectively. The most prominent OXA-types were OXA-58-like (46.5%) and OXA-23-like (41.2%), followed by OXA-24-like (10.5%), with notable regional differences. Carbapenem-hydrolyzing class D carbapenemases (CHDLs) were the only carbapenemases found in A.baumannii isolates in Austria since no metallo-β-lactamases (MBLs) nor KPC or GES carbapenemases were detected in any of the isolates. One-third of the isolates harbored multiple CHDLs. The population structure of A. baumannii isolates from Austria was found to be very diverse, while a total of twenty-three different sequence types (STs) were identified. The most frequent was ST195 found in 15.8%, followed by ST218 and ST231 equally found in 11.4% of isolates. Two new ST types, ST2025 and ST2026, were detected. In one A. pittii isolate, blaOXA-143-like was detected for the first time in Austria.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Diversity of Oxacillinases and Sequence Types in Carbapenem-Resistant Acinetobacter baumannii from Austria

Grisold¹,

Luxner²,

Bedenić

et al. 2021

IJERPH

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“…Notably, similar strains of Enterococcus faecium resistant to vancomycin were detected in pig manure and in clinical samples (Freitas et al., 2011a). Carbapenem‐resistant A. baumannii was also detected in pig manure (Hrenović et al., 2019).…”

Section: Appendix F – Antimicrobial‐resistant Bacteria and Resistance Genes Of High Public Health Relevance In Environmental Sources Of Fmentioning

confidence: 99%

“…Noteworthy is the presence of varied ARGs in manures and in contaminated irrigation water conferring resistance to CIAs, and that are common in clinical human isolates associated with mobile genetic elements, e.g. bla CTX‐M-1 , bla CTX‐M-3 , bla CTX-M‐14 , bla CTX-M‐15 , bla CTX‐M-9 , bla CTX-M‐27 , bla OXA‐23 , bla OXA‐48 , bla NDM‐5 and bla VIM‐1 (Hrenović et al., 2019).…”

Section: Appendix F – Antimicrobial‐resistant Bacteria and Resistance Genes Of High Public Health Relevance In Environmental Sources Of Fmentioning

confidence: 99%

Role played by the environment in the emergence and spread of antimicrobial resistance (AMR) through the food chain

Koutsoumanis¹,

Allende²,

Álvarez‐Ordóñez³

et al. 2021

EFS2

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The role of food-producing environments in the emergence and spread of antimicrobial resistance (AMR) in EU plant-based food production, terrestrial animals (poultry, cattle and pigs) and aquaculture was assessed. Among the various sources and transmission routes identified, fertilisers of faecal origin, irrigation and surface water for plant-based food and water for aquaculture were considered of major importance. For terrestrial animal production, potential sources consist of feed, humans, water, air/dust, soil, wildlife, rodents, arthropods and equipment. Among those, evidence was found for introduction with feed and humans, for the other sources, the importance could not be assessed. Several ARB of highest priority for public health, such as carbapenem or extended-spectrum cephalosporin and/or fluoroquinolone-resistant Enterobacterales (including Salmonella enterica), fluoroquinolone-resistant Campylobacter spp., methicillin-resistant Staphylococcus aureus and glycopeptide-resistant Enterococcus faecium and E. faecalis were identified. Among highest priority ARGs bla CTX-M , bla VIM , bla NDM , bla OXA-48like , bla OXA-23 , mcr, armA, vanA, cfr and optrA were reported. These highest priority bacteria and genes were identified in different sources, at primary and post-harvest level, particularly faeces/manure, soil and water. For all sectors, reducing the occurrence of faecal microbial contamination of fertilisers, water, feed and the production environment and minimising persistence/recycling of ARB within animal production facilities is a priority. Proper implementation of good hygiene practices, biosecurity and food safety management systems is very important. Potential AMR-specific interventions are in the early stages of development. Many data gaps relating to sources and relevance of transmission routes, diversity of ARB and ARGs, effectiveness of mitigation measures were identified. Representative epidemiological and attribution studies on AMR and its effective control in food production environments at EU level, linked to One Health and environmental initiatives, are urgently required.

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“…Moreover, two most recent studies reported the presence and survival of carbapenem-resistant organisms harboring a plasmid-borne bla OXA-23 gene from swine manure environment from a Croatian pig farm and NDM-5 producing E. coli ST156 from a poultry farm in China. These suggest the possible dissemination of CRE in the food chain through animal manure fertilization [ 111 , 112 ]. On the other hand, irrigation water and various water matrices are also considered as major source of fresh produce contamination with resistant bacteria including CRE that can potentially be transferred to the consumer especially when consumed raw [ 113 ].…”

Section: Carbapenemases-producing Enterobacteriaceae mentioning

confidence: 99%

Molecular Epidemiology of Carbapenemases in Enterobacteriales from Humans, Animals, Food and the Environment

et al. 2020

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The Enterobacteriales order consists of seven families including Enterobacteriaceae, Erwiniaceae, Pectobacteriaceae, Yersiniaceae, Hafniaceae, Morganellaceae, and Budviciaceae and 60 genera encompassing over 250 species. The Enterobacteriaceae is currently considered as the most taxonomically diverse among all seven recognized families. The emergence of carbapenem resistance (CR) in Enterobacteriaceae caused by hydrolytic enzymes called carbapenemases has become a major concern worldwide. Carbapenem-resistant Enterobacteriaceae (CRE) isolates have been reported not only in nosocomial and community-acquired pathogens but also in food-producing animals, companion animals, and the environment. The reported carbapenemases in Enterobacteriaceae from different sources belong to the Ambler class A (blaKPC), class B (blaIMP, blaVIM, blaNDM), and class D (blaOXA-48) β-lactamases. The carbapenem encoding genes are often located on plasmids or associated with various mobile genetic elements (MGEs) like transposons and integrons, which contribute significantly to their spread. These genes are most of the time associated with other antimicrobial resistance genes such as other β-lactamases, as well as aminoglycosides and fluoroquinolones resistance genes leading to multidrug resistance phenotypes. Control strategies to prevent infections due to CRE and their dissemination in human, animal and food have become necessary. Several factors involved in the emergence of CRE have been described. This review mainly focuses on the molecular epidemiology of carbapenemases in members of Enterobacteriaceae family from humans, animals, food and the environment.

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Carbapenem-Resistant Acinetobacter baumannii Recovered from Swine Manure

Cited by 15 publications

References 28 publications

Diversity of Oxacillinases and Sequence Types in Carbapenem-Resistant Acinetobacter baumannii from Austria

Diversity of Oxacillinases and Sequence Types in Carbapenem-Resistant Acinetobacter baumannii from Austria

Role played by the environment in the emergence and spread of antimicrobial resistance (AMR) through the food chain

Molecular Epidemiology of Carbapenemases in Enterobacteriales from Humans, Animals, Food and the Environment

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