Multidrug-Resistant<i>Acinetobacter baumannii</i>: An Emerging Health Threat in Aseer Region, Kingdom of Saudi Arabia

Almaghrabi, Mohammed Khamash; Joseph, Martin R.P.; Assiry, Mohammed M.; Hamid, Mohamed E.

doi:10.1155/2018/9182747

Cited by 35 publications

(29 citation statements)

References 16 publications

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“…A study conducted in the southern region of Saudi Arabia showed that 74% of Acinetobacter isolates had MDR of which 50% were sensitive to colistin. These were resistant to all the other antimicrobials studied (Falagas et al, 2015;Almaghrabi et al, 2018).…”

Section: Resultsmentioning

confidence: 94%

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Antimicrobial resistance pattern of Acinetobacter spp. isolated from clinical samples in a tertiary care hospital at Madinah, Saudi Arabia

Ghanem¹,

Shafey²,

Manzoor³

2018

Afr. J. Microbiol. Res.

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Multidrug resistance, in rapidly spreading bacterial species, is a matter of concern in health care units. Samples (6840) collected from a Saudi hospital in Madinah, were screened for Acinetobacter spp. and studied for frequency, gender distribution, and seasonal variations besides antimicrobial resistance pattern. Acinetobacter strains represented 5.5% of the clinical isolates from different sources. Of these, 63% were recovered from male samples. The largest numbers of these organisms were isolated from sputum and wound swabs representing about 85% of the samples. Antimicrobial sensitivity pattern showed that colistin was the most effective drug since it inhibited 76% of the Acinetobacter isolates. The remaining drugs did not reveal sensitivity greater than 15%. Results suggest colistin to be a promising drug in the treatment of Acinetobacter infections. It was also observed that percentage of these infections was highest during summers representing 39.15%, followed by autumn (28.17%) and winters (26.48%), while spring season recorded the least percentage with only 6.2% of infections. The present study was an attempt to generate data on the prevalence of resistance pattern and management of Acinetobacter infections.

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Section: Resultsmentioning

confidence: 94%

“…Studies have shown that the most frequently isolated organism from ICU patients of tertiary care hospitals in Riyadh, Saudi Arabia is A. baumannii (Saeed et al, 2010;Kamolvit et al, 2015). High infection rates have been reported from the southern region of Saudi Arabia (Al Bshabshe et al, 2016;Almaghrabi et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial resistance pattern of Acinetobacter spp. isolated from clinical samples in a tertiary care hospital at Madinah, Saudi Arabia

Ghanem¹,

Shafey²,

Manzoor³

2018

Afr. J. Microbiol. Res.

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“…[12]. A recent study from the Aseer region reported an MDR rate as high as 69% for Acinetobacter baumannii, with only 0.05% and 0.04% of these bacteria susceptible to imipenem and meropenem, respectively [13].…”

Section: Introductionmentioning

confidence: 99%

Pathogenic spectrum of blood stream infections and resistance pattern in Gram-negative bacteria from Aljouf region of Saudi Arabia

Bandy

Almaeen

2020

PLoS ONE

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Background The pathogenic spectrum of bloodstream infections (BSIs) varies across regions. Monitoring the pathogenic profile and antimicrobial resistance is a prerequisite for effective therapy, infection control and for strategies aimed to counter antimicrobial resistance. The pathogenic spectrum of BSIs in blood cultures was analysed, focusing on the resistance patterns of Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae, in Aljouf region. Methods This descriptive cross-sectional study analysed the culture reports of all non-duplicate blood samples collected from January 1 to December 31, 2019. Antibiograms of A. baumannii, E. coli, and K. pneumoniae were analysed for antibiotic resistance. The frequency and percentages of multi-drug, extensively-drug, pan-drug and carbapenem resistance were calculated. Results Of the 222 bloodstream infections, 62.2% and 36.4% were caused by gram-negative and gram-positive bacteria, respectively. Most BSIs occurred in patients aged �60 years (59.5%). Among the 103 isolates of the studied Gram-negative bacteria (GNB), 47.6%, 38.8%, and 2.9% were multi-drug, extensively drug and pan-drug resistant respectively. 46% of K. pneumoniae isolates were carbapenemase producers. Resistance to gentamycin, 1 st-4 th generation cephalosporins, and carbapenems was observed for A. baumannii. More than 70% of E. coli isolates were resistant to 3 rd-and 4 th-generation cephalosporins. Klebsiella pneumoniae presented a resistance rate of >60% to imipenems.

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“…The drug resistance rate against carbapenems of this organism is alarmingly high. It is extensively reported that carbapenem resistant strains of Acinetobacter baumannii (CRAB) have caused the hospital outbreaks worldwide [ 2 – 4 ].…”

Section: Introductionmentioning

confidence: 99%

Molecular characterization of multidrug resistant strains of Acinetobacter baumannii isolated from pediatric intensive care unit in a Chinese tertiary hospital

Chen

Guo

et al. 2018

BMC Infect Dis

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BackgroundAcinetobacter baumannii is a nosocomial pathogen which is reported as a major cause of morbidity and mortality in intensive care units (ICUs). However, there is a lack of analysis focused on multidrug-resistant Acinetobacter baumannii (MDRAB) infection among patients from pediatric intensive care unit (PICU) in China. The aim of this study was to investigate the molecular characterization of MDRAB isolated from PICU.MethodsIn this study, 86 isolates of MDRAB were collected from PICU patients, from the First Affiliated Hospital of Sun Yat-sen University. The minimal inhibitory concentrations (MICs) of the isolates against common antibiotics were determined. The carbapenemase-encoding resistance genes and AdeABC-AdeRS efflux system genes of these isolates were detected by PCR. Real-time PCR was performed to determine the relative expression of the relevant efflux pumps.ResultsAmong 86 strains of MDRAB, 76.7% (66/86) were carbapenem-resistant A. baumannii (CRAB). All 86 clinical isolates possessed the blaOXA-51 gene. BlaOXA-23 was detected as the second most frequent (90.7%) carbapenemase. Harboring AdeABC efflux pump genes was prevalent among the majority of the MDR isolates. Specially, the distributions of AdeABC-AdeRS efflux system genes in CRAB strains reached up to 90.0%. Compared with those of the CSAB strains, there was a statistically significant increasing distribution of the regulator AdeR and AdeS genes(p < 0.05). Moreover, CRAB strains showed significantly increased expression of AdeB(12.3- fold), but decreased expression of AdeR (3.3- fold)(p < 0.05).ConclusionThe present study showed a high distribution of multiple genes, mainly the genes of blaOXA-23/blaOXA-51 carbapenemase and AdeABC efflux pump, is responsible to distinct drug-resistance in PICU. It is urgent to strengthen the molecular epidemiological surveillance of pediatric MDRAB isolates to prevent further outbreaks. This study is of significant help for the clinicians to make therapeutic decisions and manage infection control in PICU.

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Multidrug-ResistantAcinetobacter baumannii: An Emerging Health Threat in Aseer Region, Kingdom of Saudi Arabia

Cited by 35 publications

References 16 publications

Antimicrobial resistance pattern of Acinetobacter spp. isolated from clinical samples in a tertiary care hospital at Madinah, Saudi Arabia

Antimicrobial resistance pattern of Acinetobacter spp. isolated from clinical samples in a tertiary care hospital at Madinah, Saudi Arabia

Pathogenic spectrum of blood stream infections and resistance pattern in Gram-negative bacteria from Aljouf region of Saudi Arabia

Molecular characterization of multidrug resistant strains of Acinetobacter baumannii isolated from pediatric intensive care unit in a Chinese tertiary hospital

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