The Toxicity of Thoracic Duct Fluid After Release of Tourniquets Applied to the Hind Legs of Dogs for the Production of Shock

Katzenstein, R.; Mylon, E.; Winternitz, M. C.

doi:10.1152/ajplegacy.1943.139.2.307

Cited by 8 publications

(1 citation statement)

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“…Circulatory shock is often encountered clinically. Katzenstein et al, in 1943, suggested that toxic substances induce traumatic shock (1). Since then various substances responsible for the genesis of shock such as myocardial depressant factor have been demonstrated (2).…”

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Leukotoxin, 9,10-epoxy-12-octadecenoate: A Possible Responsible Factor in Circulatory Shock and Disseminated Intravascular Coagulation.

Hanaki

Kamiya²,

Ohno³

et al. 1991

Jpn J Med

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We previously demonstrated that neutrophils biosynthesize the Iinoleate epoxide, 9,10epoxy-12-octadecenoate, from Iinoleate and hydroxyl radical. This epoxide is highly cytotoxic, and has been termed leukotoxin. Wedetected leukotoxin in plasma from two patients with infectious endocarditis and circulatory shock. Maximal leukotoxin levels were 580 nmol/ml and 880 nmol/ml, respectively. The leukotoxin levels were affected by hemodialysis or hemofiltration. Disseminated intravascular coagulation was confirmed by blood coagulation studies in these two patients. Leukocytosis was also observed in these patients. In contrast, leukotoxin was not detected in plasma of normal volunteers. Accordingly, leukotoxin synthesized by recruited neutrophils might be a contributory factor in circulatory shock.

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confidence: 99%