The timeliness of patients reporting the side effects of chemotherapy

Olver, Ian; Carey, Mariko; Boyes, Allison; Hall, Alix; Noble, Natasha; Bryant, Jamie; Walsh, Justin; Sanson‐Fisher, Rob

doi:10.1007/s00520-018-4225-y

Cited by 21 publications

(12 citation statements)

References 26 publications

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“…3,4 Moreover, there are at least 40 side-effects experienced by patients caused by cytotoxic chemoagents, such as anaphylaxis, cytopenias, hepatotoxicity, cardiotoxicity, diarrhea, nausea or vomiting, and many more. 5,6 Reduction in the dose of chemoagents not only restricts their effectiveness toward cancer cells but also leads to inadequate treatment and a slow recovery period. 7 Compared to the chemoagents, the biologically active compounds of the medicinal plants possess potent anti-inflammatory, antibacterial, antioxidant, and anticancer activity, which cure various diseases such as cancer without causing toxicity.…”

Section: ■ Introductionmentioning

confidence: 99%

pH-Triggered Drug Release Controlled by Poly(Styrene Sulfonate) Growth Hollow Mesoporous Silica Nanoparticles

et al. 2020

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In the current report, hollow mesoporous silica (HMS) nanoparticles were successfully prepared by means of a hard-templating method and further modified with poly(styrene sulfonate) (PSS) via radical polymerization. Structural analysis, surface spectroscopy, and thermogravimetric characterization confirmed a successful surface modification of HMS nanoparticles. A hairy PSS was clearly visualized by high-resolution transmission electron microscopy measurement, and it is grown on the surface of HMS nanoparticles. The Brunauer− Emmett−Teller surface area and average pore size of HMS nanoparticles were reduced after surface modification because of the pore-blocking effect, which indicated that the PSS lies on the surface of nanoparticles. Nevertheless, the PSS acts as a "nano-gate" to control the release of curcumin which is triggered by pH. The drug-release profile of unmodified HMS nanoparticles showed a stormed release in both pH 7.4 and 5.0 of phosphate buffer saline buffer solution. However, a slow release (9.92% of cumulative release) of curcumin was observed at pH 7.4 when the surface of HMS nanoparticles was modified by PSS. The kinetic release study showed that the curcumin release mechanism from PSS@HMS nanoparticles followed the Ritger−Peppas kinetic model, which is the non-Fickian diffusion. Therefore, the PSS-decorated HMS nanoparticles demonstrate potential for pH-triggered drug release transport.

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Section: ■ Introductionmentioning

confidence: 99%

pH-Triggered Drug Release Controlled by Poly(Styrene Sulfonate) Growth Hollow Mesoporous Silica Nanoparticles

et al. 2020

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“…According to the World Health Organization (WHO), cancer is among the top leading causes of nearly 10.0 million deaths worldwide in 2020 (1,2). Even though traditional treatment methods, such as invasive surgery, chemotherapy, targeted therapy, and radiation, have prevailed and made tremendous progress in the clinical setting, these regimens still face some inherent limitations in terms of therapeutic efficacy and safety (3)(4)(5)(6). To address these issues, cancer immunotherapy, also known as immuno-oncology, has stepped into the spotlight and many kinds of immune therapeutics are investigated in the research and development stage (7,8).…”

Section: Introductionmentioning

confidence: 99%

Polymeric Systems for Cancer Immunotherapy: A Review

Le¹,

Yoon²,

Thambi³

et al. 2022

Front. Immunol.

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Immunotherapy holds enormous promise to create a new outlook of cancer therapy by eliminating tumors via activation of the immune system. In immunotherapy, polymeric systems play a significant role in improving antitumor efficacy and safety profile. Polymeric systems possess many favorable properties, including magnificent biocompatibility and biodegradability, structural and component diversity, easy and controllable fabrication, and high loading capacity for immune-related substances. These properties allow polymeric systems to perform multiple functions in immunotherapy, such as immune stimulants, modifying and activating T cells, delivery system for immune cargos, or as an artificial antigen-presenting cell. Among diverse immunotherapies, immune checkpoint inhibitors, chimeric antigen receptor (CAR) T cell, and oncolytic virus recently have been dramatically investigated for their remarkable success in clinical trials. In this report, we review the monotherapy status of immune checkpoint inhibitors, CAR-T cell, and oncolytic virus, and their current combination strategies with diverse polymeric systems.

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“…Although therapeutic strategies have improved through the years, the prognosis remains poor and the disease remains incurable in many patients that have metastatic risk and drug-resistant tumours [3,4]. Considering the adverse effects of the current treatment strategies, there is a need for safe alternative treatments with little to no adverse side effects [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

In Vitro Comparison of the Anti-Proliferative Effects of Galenia africana on Human Skin Cell Lines

et al. 2021

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Malignant melanoma is the major cause of skin cancer-related deaths. Surgery in combination with radiotherapy, immunotherapy or chemotherapy is used to eradicate cancer cells, however, this treatment option is limited by the tolerance of the surrounding healthy tissue. The extracts from Galenia africana have been shown to possess anti-cancer flavonoid compounds and can be a safer and cost-effective alternative treatment. The study aimed to compare the anti-proliferative effects of G. africana on human skin cells (HaCaT) and human malignant melanoma cells (A375). The cells were exposed to various concentrations of the G. africana extract at different times. In vitro assays were employed to determine cell viability and cytotoxicity. Hoechst 33342 staining was performed to observe the nuclear changes, including apoptosis. G. africana significantly reduced the cell viability of the A375 cells in a dose and time-dependent manner, while having no effect on the HaCaT cells. The A375 cells displayed nuclear condensation, brightly stained nuclei and nuclear fragmentation indicative of apoptosis. This suggests a clinical rationale for the use of G. africana as a potential anti-melanoma agent offering efficacy and low toxicity. This study provides new insights for future work on investigating the utilization of G. africana in malignant melanoma treatment.

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The timeliness of patients reporting the side effects of chemotherapy

Abstract: Tools need to be created so that patients better understand the side effects after being treated with chemotherapy and what action they should take.

Cited by 21 publications

References 26 publications

pH-Triggered Drug Release Controlled by Poly(Styrene Sulfonate) Growth Hollow Mesoporous Silica Nanoparticles

pH-Triggered Drug Release Controlled by Poly(Styrene Sulfonate) Growth Hollow Mesoporous Silica Nanoparticles

Polymeric Systems for Cancer Immunotherapy: A Review

In Vitro Comparison of the Anti-Proliferative Effects of Galenia africana on Human Skin Cell Lines

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