pH-Triggered Drug Release Controlled by Poly(Styrene Sulfonate) Growth Hollow Mesoporous Silica Nanoparticles

Abstract

In the current report, hollow mesoporous silica (HMS) nanoparticles were successfully prepared by means of a hard-templating method and further modified with poly(styrene sulfonate) (PSS) via radical polymerization. Structural analysis, surface spectroscopy, and thermogravimetric characterization confirmed a successful surface modification of HMS nanoparticles. A hairy PSS was clearly visualized by high-resolution transmission electron microscopy measurement, and it is grown on the surface of HMS nanoparticles. The Brunauer− Emmett−Teller surface area and average pore size of HMS nanoparticles were reduced after surface modification because of the pore-blocking effect, which indicated that the PSS lies on the surface of nanoparticles. Nevertheless, the PSS acts as a "nano-gate" to control the release of curcumin which is triggered by pH. The drug-release profile of unmodified HMS nanoparticles showed a stormed release in both pH 7.4 and 5.0 of phosphate buffer saline buffer solution. However, a slow release (9.92% of cumulative release) of curcumin was observed at pH 7.4 when the surface of HMS nanoparticles was modified by PSS. The kinetic release study showed that the curcumin release mechanism from PSS@HMS nanoparticles followed the Ritger−Peppas kinetic model, which is the non-Fickian diffusion. Therefore, the PSS-decorated HMS nanoparticles demonstrate potential for pH-triggered drug release transport.

Antioxidant activity and controlled‐release feature of Quercetin loaded amines‐functionalized magnetically porous cellulose

“…This slow release behavior is possibly due to the synergistic effect of amines functional group, mesoporous structure of Fe 3 O 4 , and macro‐pores feature of PC that bind effectively the quercetin molecules and slow down its diffusion process until it is released to the system. The presence of additional functional groups, either positive or negative charges, in slowing drug release from drug delivery system was also reported by researchers 14,57,63–65 …”

WITHDRAWN: Synthesis of Hydrophobic and Hydrophilic Loaded Mesoporous Silica Nanoparticles for Controlled Co-Delivery of Drugs

“…MSNPs were synthesized by the hydrothermal method as per previous reports with slight modi cation [23,24]. The mixture of CTAB (2.69 g) to the double distilled (DD) water allows dissolving completely by stirring.…”

Hollow Silica Particles: Recent Progress and Future Perspectives

“…HSPs have also been synthesized by using organisms such as viruses and bacteria [ 36 , 37 , 38 ]. When using Gram-negative bacteria such as E. coli , water inside the bacteria acts as an initiator for hydrolysis of the silica precursor, TEOS.…”