The time window for successful right-hemispheric language reorganization in children

Lidzba, Karen; Küpper, Hanna; Kluger, Gerhard; Staudt, Martin

doi:10.1016/j.ejpn.2017.06.001

Cited by 36 publications

(33 citation statements)

References 27 publications

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“…In light of the FC changes post-surgically in adults, and the greater potential for plasticity during childhood than adulthood 7 , 14 , 22 , we undertook to characterize comprehensively the FC in a pediatric cohort, the majority of whom had a visual cortical resection. Now, there are two relevant questions here: the ‘what’ and the ‘how’.…”

Section: Introductionmentioning

confidence: 99%

Large-scale resculpting of cortical circuits in children after surgical resection

Maallo

Granovetter

Freud

et al. 2020

Sci Rep

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Despite the relative successes in the surgical treatment of pharmacoresistant epilepsy, there is rather little research on the neural (re)organization that potentially subserves behavioral compensation. Here, we examined the post-surgical functional connectivity (FC) in children and adolescents who have undergone unilateral cortical resection and, yet, display remarkably normal behavior. Conventionally, FC has been investigated in terms of the mean correlation of the BOLD time courses extracted from different brain regions. Here, we demonstrated the value of segregating the voxel-wise relationships into mutually exclusive populations that were either positively or negatively correlated. While, relative to controls, the positive correlations were largely normal, negative correlations among networks were increased. Together, our results point to reorganization in the contralesional hemisphere, possibly suggesting competition for cortical territory due to the demand for representation of function. Conceivably, the ubiquitous negative correlations enable the differentiation of function in the reduced cortical volume following a unilateral resection.

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Section: Introductionmentioning

confidence: 99%

Large-scale resculpting of cortical circuits in children after surgical resection

Maallo

Granovetter

Freud

et al. 2020

Sci Rep

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“…14 Lidzba et al investigated twelve patients (five children) who experienced a left hemisphere stroke in childhood with language fMRI and questionnaires for self-assessment of language problems. 15 Language lateralization towards the right hemisphere, which occurred only in the younger participants, was found to be favorable for language outcome in their study. In contrast, no study exists on the relationship between language abilities and functional language localization after right-sided childhood stroke.…”

Section: Introductionmentioning

confidence: 64%

“…Right lateralized language following left hemisphere stroke has already been reported in studies on perinatal stroke 12, 50–52 and in studies on childhood stroke. 9, 13–15, 41, 53, 54 These studies have reported increased activity in right hemisphere areas homotopic to left hemisphere language regions after childhood stroke. Recent findings of Westmacott et al suggest that reorganization of language function may be more likely to involve bilateral recruitment following left stroke in childhood than in adulthood.…”

Section: Discussionmentioning

confidence: 93%

“…In contrast, Lidzba et al investigated twelve patients, five of whom where children, who suffered from a left hemisphere stroke in childhood and found right lateralized language to be favorable for language outcome. 15 However, language outcome in this study was only examined by a questionnaire to the patient or the parents, which limits information on language abilities. The present study shows that the relationship between language functioning and language lateralization is present across a wide range of lesion volumes and irrespective of the hemispheric side of the lesion.…”

Section: Discussionmentioning

confidence: 99%

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Atypical language representation is unfavorable for language abilities following childhood stroke

Bartha‐Doering

Novak

Kollndorfer

et al. 2019

European Journal of Paediatric Neurology

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Brain plasticity has often been quoted as a reason for the more favorable outcome in childhood stroke compared to adult stroke. We investigated the relationship between language abilities and language localization in childhood stroke. Seventeen children and adolescents with left- or right-sided ischemic stroke and 18 healthy controls were tested with a comprehensive neurolinguistic test battery, and the individual neural representation of language was measured with an fMRI language paradigm. Overall, 12 of 17 stroke patients showed language abilities below average, and five patients exhibited impaired language performance. fMRI revealed increased activity in right hemisphere areas homotopic to left hemisphere language regions. In sum, seven stroke patients revealed atypical, i.e. bilateral or right lateralized language representation. Typical left hemispheric language lateralization was associated with better performance in naming and word fluency, whereas increased involvement of right homologues was accompanied by worse language outcome. In contrast, lesion lateralization or lesion volume did not correlate with language outcome or atypical language lateralization. Thus, atypical language lateralization is unfavorable for language outcome, and right homologues do not have the same cognitive capacity, even in young children.

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“…In light of the FC changes post-surgically, and the greater potential for plasticity during childhood than adulthood (Anderson et al, 2011;Helmstaeder et al, 2020;Lidzba et al, 2017), we undertook to characterize comprehensively the FC in the preserved hemisphere of a pediatric sample. We used data acquired during a visual category localizer task, rather than during resting state, both to ensure that we were able to elicit sufficient BOLD signal from the young patients and to validate the connectivity of functionally specific ROIs.…”

Section: Characterizing Detailed Functional Connectivity Profilesmentioning

confidence: 99%

All hands on deck: Large-scale (re)sculpting of cortical circuits in post-resection children

Maallo

Granovetter

Freud

et al. 2020

Preprint

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AbstractDespite the relative successes in the surgical treatment of pharmacoresistant epilepsy, there is rather little research on the neural (re)organization that potentially subserves behavioral compensation. Here, we examined the post-surgical functional connectivity (FC) in children and adolescents who have undergone unilateral cortical resection and, yet, display remarkably normal behavior. Conventionally, FC has been investigated in terms of the mean correlation of the BOLD time courses extracted from different brain regions. Here, we demonstrated the value of segregating the voxel-wise relationships into mutually exclusive populations that were either positively or negatively correlated. While, relative to controls, the positive correlations were largely normal, negative correlations among networks were increased. Together, our results point to reorganization in the contralesional hemisphere, possibly suggesting competition for cortical territory due to the demand for representation of function. Conceivably, the ubiquitous negative correlations enable the differentiation of function in the reduced cortical volume following a unilateral resection.

show abstract

The time window for successful right-hemispheric language reorganization in children

Cited by 36 publications

References 27 publications

Large-scale resculpting of cortical circuits in children after surgical resection

Large-scale resculpting of cortical circuits in children after surgical resection

Atypical language representation is unfavorable for language abilities following childhood stroke

All hands on deck: Large-scale (re)sculpting of cortical circuits in post-resection children

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