2007
DOI: 10.1124/mol.107.039081
View full text |Buy / Rent full text
|
Sign up to set email alerts
|

Abstract: Telomere repeat binding factor 2 (TRF2) has been increasingly recognized to be involved in DNA damage response and telomere maintenance. Our previous report found that salvicine (SAL), a novel topoisomerase II poison, elicited DNA doublestrand breaks and telomere erosion in separate experimental systems. However, it remains to be clarified whether they share a common response to these two events and in particular whether TRF2 is involved in this process. In this study, we found that SAL concurrently induced DN… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

0
14
0

Year Published

2009
2009
2014
2014

Publication Types

Select...
4

Relationship

0
4

Authors

Journals

citations
Cited by 16 publications
(14 citation statements)
references
References 42 publications
(71 reference statements)
0
14
0
Order By: Relevance
“…The median numbers of foci/nucleus are shown numerically and as red dots. (3,28), along with results from others showing that TRF2 performs roles in the DNA damage response (17,19,20,22,30), strongly suggest that TRF2 functions at DNA DSBs and that DNA damage-induced phosphorylation of TRF2 may facilitate its localization to these damage sites. Additionally, DNA damage-induced phosphorylation of TRF2 may function to allow TRF2 to perform a direct role as a mediator or effector in the DNA damage response.…”
Section: Discussionmentioning
confidence: 92%
See 1 more Smart Citation
“…The median numbers of foci/nucleus are shown numerically and as red dots. (3,28), along with results from others showing that TRF2 performs roles in the DNA damage response (17,19,20,22,30), strongly suggest that TRF2 functions at DNA DSBs and that DNA damage-induced phosphorylation of TRF2 may facilitate its localization to these damage sites. Additionally, DNA damage-induced phosphorylation of TRF2 may function to allow TRF2 to perform a direct role as a mediator or effector in the DNA damage response.…”
Section: Discussionmentioning
confidence: 92%
“…These reports suggest that TRF2 (i) is required for the repair of DBS breaks via the homologous recombination pathway (17), (ii) interacts at nontelomeric sites physically and genetically with several proteins known to function in various pathways of DNA repair (19,20), (iii) plays an important role in drug resistance (22,30), and (iv) migrates to DNA damage sites (3,28). One report repeated previous results regarding TRF2 migration to DNA damage sites using the same damage source as used by Bradshaw et al (3) but did not observe TRF2 at damage sites using another damage source (29).…”
Section: Discussionmentioning
confidence: 99%
“…Mice genetically deficient in CXCR7 have abnormalities in their cardiovascular and central nervous systems [12]. CXCR7 expression in NSCL and breast cancer is correlated with lymph node metastasis and poor prognosis [66,67]. …”
Section: Discussionmentioning
confidence: 99%
“…In unicellular eukaryotes, topoisomerase 2 was shown to play a role in telomeres segregation in the fission yeast (Germe et al, 2009). In human cells, the telomeric G4-targeting molecule RHPS4 potentiates the anti-tumor efficacy of TOPO I (topoisomerase I) inhibitors in preclinical models (Leonetti et al, 2008; Biroccio et al, 2011) and TRF2 protects against the damages caused by topoisomerase 2 poisons (Klapper et al, 2003; Zhang et al, 2008). Furthermore, topoisomerase 2α is required for telomere protection in a pathway involving TRF2 and its partner Apollo (Ye et al, 2010).…”
Section: Topological Stress: An Emerging Theme In Telomere Biologymentioning
confidence: 99%