2014
DOI: 10.1186/bcr3665
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Abstract: IntroductionAlthough C-X-C motif chemokine 12 (CXCL12) has been shown to bind to C-X-C chemokine receptor type 7 (CXCR7), the exact molecular mechanism regulations by CXCL12/CXCR7 axis in breast tumor growth and metastasis are not well understood. CXCR7 expression has been shown to be upregulated during pathological processes such as inflammation and cancer.MethodsBreast cancer cell lines were genetically silenced or pharmacologically inhibited for CXCR7 and/or its downstream target signal transducer and activ… Show more

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Cited by 94 publications
(108 citation statements)
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“…In the present study, siRNA mediated downregulation of CXCR7 expression in human cervical cancer cells led to a significant decrease in SiHa cell proliferation and invasion. This result is consistent with previous breast cancer studies showing that CXCR7 mediates the invasive and metastatic potential of breast cancer cells (Wani et al, 2014). The direct effect of CXCL12/CXCR7 in breast cancer metastasis is that CXCR7 recruits tumor-promoting macrophages to the tumor site through regulation of the macrophage colony-stimulating factor/macrophage colony-stimulating factor receptor signaling pathway.…”
Section: Discussionsupporting
confidence: 92%
See 1 more Smart Citation
“…In the present study, siRNA mediated downregulation of CXCR7 expression in human cervical cancer cells led to a significant decrease in SiHa cell proliferation and invasion. This result is consistent with previous breast cancer studies showing that CXCR7 mediates the invasive and metastatic potential of breast cancer cells (Wani et al, 2014). The direct effect of CXCL12/CXCR7 in breast cancer metastasis is that CXCR7 recruits tumor-promoting macrophages to the tumor site through regulation of the macrophage colony-stimulating factor/macrophage colony-stimulating factor receptor signaling pathway.…”
Section: Discussionsupporting
confidence: 92%
“…This result indicated that the CXCL12/CXCR7signaling pathway promotes tumor cell proliferation. It is is consistent with previous breast cancer studies showing that the CXCL12 /CXCR7 axis supports cancer cell growth (Wani et al, 2014). The mechanisms and signaling pathways involved in CXCL12/CXCR7 have been reported in pancreatic cancer and the results indicated that CXCR4 and CXCR7 signaling is b-arrestin-2-dependent and controls CXCL12 signals to the MAPK/AKT pathway (Miao et al, 2007).…”
Section: Discussionsupporting
confidence: 92%
“…C-X-C motif chemokine 12/C-X-C chemokine receptor type 7(CXCR7) has been shown to regulate breast cancer metastasis by enhancing expression of MMP-2, MMP-9 and vascular cell-adhesion molecule-1 (VCAM-1). CXCR7 was determined to be highly expressed in human invasive ductal carcinoma (IDC) and metastatic breast tissues [148]. MMP-9, like NGAL, is an NFkappaB-responsive gene.…”
Section: Mmp-9 and Ngal And The Tumor Microenvironmentmentioning
confidence: 99%
“…Importantly, we showed recently, in one of our studies, that CXCL12/CXCR4 is not the only axis involved in CXCL12-mediated breast cancer metastasis [141]. In this study, we have shown that the CXCL12/CXCR7 axis plays an important role in breast cancer growth and metastasis by modulating the TME.…”
Section: Cxcl12mentioning
confidence: 69%