2013
DOI: 10.3389/fonc.2013.00048
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Abstract: A major issue in telomere research is to understand how the integrity of chromosome ends is controlled. The fact that different types of nucleoprotein complexes have been described at the telomeres of different organisms raises the question of whether they have in common a structural identity that explains their role in chromosome protection. We will review here how telomeric nucleoprotein complexes are structured, comparing different organisms and trying to link these structures to telomere biology. It emerge… Show more

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Cited by 56 publications
(57 citation statements)
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“…The length of telomeres and the chromatin organization of telomeric regions influence telomere functions. Hence, the epigenetic marks that label telomeric regions, which include telomeres and subtelomeres, play important roles in telomere biology (Blasco 2007;Galati et al 2013;Giraud-Panis et al 2013). …”
mentioning
confidence: 99%
“…The length of telomeres and the chromatin organization of telomeric regions influence telomere functions. Hence, the epigenetic marks that label telomeric regions, which include telomeres and subtelomeres, play important roles in telomere biology (Blasco 2007;Galati et al 2013;Giraud-Panis et al 2013). …”
mentioning
confidence: 99%
“…Since this early discovery, numerous variations in telomere nucleoprotein organization have been found [1]. For instance, in the budding yeast Saccharomyces cerevisiae, the 3′ overhang is bound by Cdc13, whereas the duplex portion is covered by an array of Rap1 proteins.…”
mentioning
confidence: 99%
“…The concept that telomere functionality relies on specific DNA-protein interactions stems from the discovery of the TEBPα/β heterodimer from Oxytrichia nova that binds to and protects the G-rich 3′ overhang that constitutes the end of telomeric DNA across many species [1]. Since this early discovery, numerous variations in telomere nucleoprotein organization have been found [1].…”
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confidence: 99%
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