The systemic inflammation-based Glasgow Prognostic Score: A decade of experience in patients with cancer

McMillan, Donald C.

doi:10.1016/j.ctrv.2012.08.003

Cited by 1,133 publications

(1,094 citation statements)

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“…Other studies have comprehensively validated the prognostic value of mGPS/GPS in a variety of advanced malignancies, including gastric cancer (Leitch et al, 2007;Hwang et al, 2011;Jiang et al, 2012;Fox et al, 2013;McMillan 2013).The results of the present study are consistent with previous reports, and suggest that GPS showed superior prognostic value to NLR in locally advanced or metastatic gastric cancer. In our study, only five patients had a GPS of 2, with a poor outcome consistent with previous evidence (Crumley et al, 2006;Hwang et al, 2011).…”

Section: Discussionsupporting

confidence: 92%

“…Therefore, there is continuing interest in prognostic factors to permit more accurate A growing body of evidence demonstrates that patient outcomes in cancer are determined not only by tumor-related factors but also by host-related factors, particularly, the systemic inflammatory response (Colotta et al, 2009;Hanahan et al, 2011). Several recent studies have revealed a correlation between clinical outcomes with common solid tumors (colorectal cancer, lung cancer, breast cancer and pancreatic cancer, etc) and systemic inflammatory response, including plasma C-reactive protein (CRP), hypoalbuminemia, and a selective combination of C-reactive protein and albumin termed as Glasgow Prognostic Score (GPS) (Leitch et al, 2007;Hwang et al, 2011;Jiang et al, 2012;Fox et al, 2013;McMillan, 2013). There were also many studies reporting that haematological markers of systemic inflammatory response such as white blood cell count or its components (neutrophil, lymphocyte, neutrophil-lymphocyte ratio (NLR)), platelet, and platelet-lymphocyte ratio (PLR) are also prognostic indicators for cancer clinical outcomes (Yamanaka et al, 2007;Cho et al, 2009;Kishi et al, 2009;Sarraf et al, 2009;Kwon et al, 2012;Dalpiaz et al, 2013;Fox et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Neutrophil Count and the Inflammation-based Glasgow Prognostic Score Predict Survival in Patients with Advanced Gastric Cancer Receiving First-line Chemotherapy

Li¹,

Lü²,

Yang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Purpose: To explore the value of systemic inflammatory markers as independent prognostic factors and the extent these markers improve prognostic classification for patients with inoperable advanced or metastatic gastric cancer (GC) receiving palliative chemotherapy. Methods: We studied the prognostic value of systemic inflammatory factors such as circulating white blood cell count and its components as well as that combined to form inflammation-based prognostic scores (Glasgow Prognostic Score (GPS), Neutrophil-Lymphocyte Ratio (NLR), Platelet Lymphocyte Ratio (PLR), Prognostic Index (PI) and Prognostic Nutritional Index (PNI)) in 384 patients with inoperable advanced or metastatic gastric cancer (GC) receiving first-line chemotherapy. Univariate and multivariate analyses were performed to examine the impact of inflammatory markers on overall survival (OS). Results: Univariate analysis revealed that an elevated white blood cell, neutrophil and/or platelet count, a decreased lymphocyte count, a low serum albumin concentration, and high CRP concentration, as well as elevated NLR/PLR , GPS, PI, PNI were significant predictors of shorter OS. Multivariate analysis demonstrated that only elevated neutrophil count (HR 3.696, p=0.003) and higher GPS (HR 1.621, p=0.01) were independent predictors of poor OS. Conclusion: This study demonstrated elevated pretreatment neutrophil count and high GPS to be independent predictors of shorter OS in inoperable advanced or metastatic GC patients treated with first-line chemotherapy. Upon validation of these data in independent studies, stratification of patients using these markers in future clinical trials is recommended.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Neutrophil Count and the Inflammation-based Glasgow Prognostic Score Predict Survival in Patients with Advanced Gastric Cancer Receiving First-line Chemotherapy

Li¹,

Lü²,

Yang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Brought to you by | MIT Libraries Authenticated Download Date | 5/12/18 11:19 PM concentration, and neutrophil to lymphocyte ratio (NLR) have recently been shown to be independent prognostic factors in the cancer patients (McMillan 2013;Guthrie et al 2013). Th e NLR has been shown to be a convenient and inexpensive prognostic biomarker in many human cancers (Azab et al 2012;Kishi et al 2009;Wang et al 2011).…”

mentioning

confidence: 99%

Neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) may be superior to C-reactive protein (CRP) for predicting the occurrence of differentiated thyroid cancer

Özmen

Timur

Çalık

et al. 2017

Endocrine Regulations

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Objectives. NLR (neutrophil-lymphocyte ratio) and PLR (platelet-lymphocyte ratio) are prognostic markers of diff erentiated thyroid cancers. In our study, we evaluated NLR, PLR and C-reactive protein (CRP) for predicting the occurence of diff erentiated thyroid cancer. Th is is the fi rst study that compares NLR and PLR to C-reactive protein indiff erantiated thyroid cancer not only papillary cancer but also folliculer cancer.Methods. Th is study includes 51 papillary carcinoma, 42 papillary microcarcinoma and 31 folliculer carcinoma patients attending to our outpatient Endocrinology Clinic at Erzurum Region Training and Research Hospital between 2009 and 2014. Th e control group include 50 age, sex and body mass index matched healty subjects. Blood counts and CRP were measured at the day before surgery. Th yroglobulin was measured aft er 6 months of operation.Results. Th ere were positive correlations between tumor diameter, age, white blood cell (WBC) and thyroglobulin levels. Th ere were also positive correlation between NLR, PLR and CRP levels.Conclusion. In our study, we found out that higher NLR and PLR was associated with higher levels of thyroglobulin which indicates worse survival. CRP levels were also associated with poorer tumor profi le but the determining rate was lower according to ROC analysis

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“…Moreover, several studies demonstrated that systemic inflammatory response is associated with poor prognosis in various cancer types [7,9,14,15]. There is also strong evidence of the correlation between malignancy and tumor stage, proliferative activity of the tumor cells and the systemic inflammatory response associated with the tumor [16].…”

Section: Discussionmentioning

confidence: 99%

“…values of albumin, pre-albumin and CRP have been investigated, different scoring systems based on various combinations of these markers or incorporating other parameters such as lymphocyte and white blood cell counts, have been recently developed; examples of which include the Glasgow prognostic score (GPS), prognostic index (PI) and prognostic nutritional index (PNI) [2,[7][8][9][10][11][12][13]. Biochemical markers such as albumin, pre-albumin and C-reactive protein (CRP) are currently used to predict prognosis in several cancer types, and the usefulness of these biomarkers in gastric cancer has become an emerging topic of research.…”

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confidence: 99%

Can Prealbumin, Albumin and CRP Levels be used to Predict Prognosis in Patients with Gastric Cancer

Üreyen¹

2016

J Surg Surgical Res

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Background: The impact of systemic inflammatory response on carcinogenesis and tumor progression has recently gained much attention. Biochemical markers such as albumin, pre-albumin and C-reactive protein (CRP) are currently used to predict prognosis in several cancer types, and the usefulness of these biomarkers in gastric cancer has become an emerging topic of research. The present study aims to assess the correlation between tumor stage and the levels of pre-albumin, albumin and CRP in patients who underwent surgery for gastric cancer.Methods: Albumin, pre-albumin and CRP levels of the patients who underwent surgery for gastric cancer in our division, were prospectively recorded and retrospectively evaluated. Age, gender, duration of hospital stay, TNM stage, and preoperative albumin, pre-albumin and CRP levels were recorded. Albumin levels lower than 3.5 mg/dL and pre-albumin levels lower than 20 mg/dL were considered to be below the normal range. CRP levels higher than 5 mg/L were considered to be elevated. Patients with another focus of inflammation were excluded from the study.Results: A total number of 41 patients, 32 (78%) men and 9 (22%) women, were included in the study. Albumin levels were significantly associated with the age (p=0.010). There was no significant correlation between disease stage, gender, presence of metastatic lymph nodes and albumin levels (p>0.05). There was a significant correlation between the TNM stage and pre-albumin levels (P=0.014). No significant correlation was demonstrated between pre-albumin levels and the other parameters (P>0.05). The independent variables were not found to be significantly different between the groups with normal and elevated CRP levels (p>0,05) Conclusions:The present study showed that the patients with lymph node metastasis and advanced stage gastric cancer more frequently have decreased levels of albumin and pre-albumin, and elevated levels of CRP. Decreased pre-albumin level was found to be associated with the TNM stage. The albumin levels were found to be decreasing by age. Although we failed to demonstrate a statistically correlation with albumin and CRP, preoperative albumin, pre-albumin and CRP levels may be useful to predict prognosis of patients with gastric cancer.

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The systemic inflammation-based Glasgow Prognostic Score: A decade of experience in patients with cancer

Cited by 1,133 publications

References 81 publications

Neutrophil Count and the Inflammation-based Glasgow Prognostic Score Predict Survival in Patients with Advanced Gastric Cancer Receiving First-line Chemotherapy

Neutrophil Count and the Inflammation-based Glasgow Prognostic Score Predict Survival in Patients with Advanced Gastric Cancer Receiving First-line Chemotherapy

Neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) may be superior to C-reactive protein (CRP) for predicting the occurrence of differentiated thyroid cancer

Can Prealbumin, Albumin and CRP Levels be used to Predict Prognosis in Patients with Gastric Cancer

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