Neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) may be superior to C-reactive protein (CRP) for predicting the occurrence of differentiated thyroid cancer

Abstract

Objectives. NLR (neutrophil-lymphocyte ratio) and PLR (platelet-lymphocyte ratio) are prognostic markers of diff erentiated thyroid cancers. In our study, we evaluated NLR, PLR and C-reactive protein (CRP) for predicting the occurence of diff erentiated thyroid cancer. Th is is the fi rst study that compares NLR and PLR to C-reactive protein indiff erantiated thyroid cancer not only papillary cancer but also folliculer cancer.Methods. Th is study includes 51 papillary carcinoma, 42 papillary microcarcinoma and 31 folliculer carcinoma patients attending to our outpatient Endocrinology Clinic at Erzurum Region Training and Research Hospital between 2009 and 2014. Th e control group include 50 age, sex and body mass index matched healty subjects. Blood counts and CRP were measured at the day before surgery. Th yroglobulin was measured aft er 6 months of operation.Results. Th ere were positive correlations between tumor diameter, age, white blood cell (WBC) and thyroglobulin levels. Th ere were also positive correlation between NLR, PLR and CRP levels.Conclusion. In our study, we found out that higher NLR and PLR was associated with higher levels of thyroglobulin which indicates worse survival. CRP levels were also associated with poorer tumor profi le but the determining rate was lower according to ROC analysis

Neutrophil-to-Lymphocyte, Monocyte-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Relation to Clinical Parameters and Smoking Status in Patients with Graves’ Orbitopathy—Novel Insight into Old Tests

“…However, little is known about the above-mentioned markers in thyroid disorders. Several authors proved that NLR may be a useful parameter in the differential diagnosis of benign thyroid nodules from malignant tumors, especially papillary thyroid carcinoma [ 17 , 37 , 38 ]. Aside from thyroid neoplasms, NLR combined with PLR have been studied as potential indicators of Hashimoto’s disease occurrence, which can allow to distinguish patients with chronic autoimmune thyroiditis from healthy individuals [ 22 , 23 , 24 , 25 ].…”

İnsidental tiroid papiller karsinomda enflamatuar hücre oranlarının prediktif değeri

“…In a study of prognostic evaluation of NLR, Kim et al reported increased NLR as a negative prognostic indicator for disease-free survival [21]. In 2017, Özmen et al reported that increased NLR and PLR levels were associated with high thyroglobulin, and, hence, poor prognosis [12].…”

<p>Prognostic Value of Neutrophil-to-Lymphocyte Ratio in Predicting Death Risk in Patients with Severe Hand, Foot and Mouth Disease</p>

“… 8 NLR is already used as an easily accessible inflammatory marker in adults with acute respiratory distress syndrome, 9 spontaneous bacterial peritonitis, 10 ischaemic heart disease, metabolic disease, cancer and other medical conditions. 11 In children, NLR can differentiate between viral and bacterial pneumonia, 12 , 13 and it can be a useful diagnostic marker of acute appendicitis and acute infection. 12 , 14 NLR may also correlate positively with other commonly used inflammatory markers.…”