The synthesis of p-tert-butyl thiacalix[4]arenes functionalized with secondary amide groups at the lower rim and their extraction properties and self-assembly into nanoscale aggregates

Mono-, 1,3-Di- and Tetrasubstituted p-tert-Butylthiacalix[4]arenes Containing Phthalimide Groups: Synthesis and Functionalization with Ester, Amide, Hydrazide and Amino Groups

“…The result obtained confirms the hypothesis that the aggregates similar to those described in literature are formed (Figure 2). [17][18][19][20][21] An unusual stoichiometry was observed for the complex of the compound 7 with K + cation. Two molecules of the receptor 7 bind one metal cation.…”

“…The residue was crystallized from Et 2 O. 5,11,17,26,27,-(Nphthalimide)propoxy) -2,8,14,20-tetrathiacalix[4] 5,11,17,propoxy) -2,8,14,20-tetrathiacalix[4] General procedure of the synthesis of the compounds 14, 15. A mixture of 1.00 g of the appropriate compound 6 or 7 and 1 ml (20 mmol) of hydrazine hydrate was refluxed in the mixture of 30 ml THF and 30 ml ethanol for 20 hrs.…”

“…From the literature it is known that thiacalix [4]arenes can form 1:1 nanoscale aggregates with the silver cations via 'soft' bridging sulphur atoms, [17][18][19][20][21] so the formation of such complex in the case of compounds 2 and 7 can be assumed.…”

p-tert-Butyl Thiacalix[4]arene Derivatives Functionalized in the Lower Rim with Bis(3-aminopropyl)amine: Synthesis and Interaction with DNA

“…or the use of reactive acyl chlorides. [25,26] This gradual shift to direct aminolysis method is due to the fact that the other methods usually give a mixture of the products and/ or those with poor yield. Unfortunately, even with direct aminolysis, most literature data is limited to the use of diamines as reagents with corresponding bridged products.…”

“…[25,[31][32][33] Thus, we believe this method can be used to monitor self-aggregation of the compounds 3 or 4 and their complexation properties toward CT-DNA.…”