Background. Till date, there is no known antidote to cure diabetes mellitus despite the discovery and development of diverse pharmacotherapeutic agents many years ago. Technological advancement in natural product chemistry has led to the isolation of analogs of vitexin and isovitexin found in diverse bioresources. These compounds have been extensively studied to explore their pharmacological relevance in diabetes mellitus. Aim of the Study. The present review was to compile results from in vitro and in vivo studies performed with vitexin and isovitexin derivatives relating to diabetes mellitus and its complications. A systematic online literature query was executed to collect all relevant articles published up to March 2020. Results. In this piece, we have collected data and presented it in a one-stop document to support the multitargeted mechanistic actions of vitexin and isovitexin in controlling diabetes mellitus and its complications. Conclusion. Data collected hint that vitexin and isovitexin work by targeting diverse pathophysiological and metabolic pathways and molecular drug points involved in the clinical manifestations of diabetes mellitus. This is expected to provide a deeper understanding of its actions and also serve as a catapult for clinical trials and application research.
In this work, the formation of two- and three-component supramolecular systems based on cone, partial cone, 1,3-alternate stereoisomers of heteroditopic "hosts": p-tert-butylthiacalix[4]arene containing 4-amidopyridine fragments with silver(I) cations and dicarboxylic acids in liquid and solid phases were studied by UV spectroscopy, dynamic light scattering, and atomic force microscopy methods. It has been shown that these macrocycles are coreceptors, capable of simultaneously binding silver(I) cations, dicarboxylic acids (oxalic, malonic, succinic, maleic, fumaric acids), and hydroxyl acids (glycol, tartaric acids). For the first time, by the dynamic light scattering method, it has been shown that the conformation of p-tert-butyl thiacalix[4]arenes significantly affects the type of three-component system formed: cone is characterized by the formation of cascade systems; for partial cone, intermediate systems; and for the 1,3-alternate stereoisomers, three types of three-component systems (cascade, intermediate, and commutative) were observed.
Background: Most plants have medicinal properties, which they achieve from certain secondary metabolites. Phytochemicals are compounds produced by plants. They may affect health but are not-essential nutrients as our diet does not require them to sustain life in the same way as vitamins and minerals. Objectives: The study reports the phytochemistry and medicinal properties of Solanum torvum fruits. Methods: A search of database sites such as PUBMED, Google Scholar, and Web of Science as well as other sources of literature available across public libraries was conducted to obtain information related to the topic. Results: Here, we review the numerous medicinal properties of S. torvum (cardio and nephro protection, anti-hypertensive, analgesic, anti-inflammatory, anti-ulcer, anti-microbial activities) and relate them to the underlying phytochemicals and their biological actions. Conclusion: This exposure is expected to provide researchers with updated information on S. torvum health benefit properties and related phytochemicals, which merit future research for developing pharmacological drugs aimed at curing ailments or diseases, and for possible use in preventive medicine.
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