p-tert-Butyl Thiacalix[4]arene Derivatives Functionalized in the Lower Rim with Bis(3-aminopropyl)amine: Synthesis and Interaction with DNA

Abstract

New tetrasubstituted derivatives of thiacalix [4]arene functionalized with bis (3-aminopropyl)

Synthesis of Three Stereoisomers of p-tert-Butylthiacalix[4]arene Substituted with (Ethoxycarbonyl)methoxy and Fluorescent 1-Amidoanthraquinone Fragments

“…The structure of the compounds obtained was established by 1 H NMR, 13 C, IR spectroscopy, mass spectrometry (MALDI-TOF), and the composition was confirmed by elemental analysis. The fluorescent properties of the obtained compounds were studied.…”

“…The obtained compounds 2-4 were characterized by NMR 1 H, 13 C, 2D NOESY, IR spectroscopy, mass spectrometry (MALDI-TOF), and their composition was confirmed by elemental analysis.…”

“…[6] Thus, the creation of fluorescent sensors is an actual problem of organic chemistry, as they are widely used in analytical chemistry, clinical biochemistry, medicine, environmental protection, in various applications of biological and biomedical research. [7] Thiacalixarenes are favorable building platform for the construction of such systems because of their unique three-dimensional structure as well as simplicity of functionalization of the macrocyclic platform [8][9][10][11][12][13][14][15][16][17][18][19] and possibility of existence of different conformational isomers (cone, partial cone, 1,2-alternate, and 1,3-alternate).…”

Modification of Oligolactic Acid with Tetracarboxylic p-tert-Butylthiacalix[4]arene Derivatives: Effect of Macrocyclic Fragment Configuration on Aggregation and Thermal Properties of Copolyesters

“…The 1 H and 13 C NMR spectra were recorded on a Bruker Avance 400 spectrometer (400.17 MHz for H-atoms) for 3-5 % solutions in СDCl 3 . The residual solvent peaks were used as an internal standard.…”

“…The relative simplicity of functionalization together with the possibility of pre-determination of the macrocycle configuration by various spatially fixed functional groups led to development of variety of the systems able to recognize various substrates, both neutral and ionic, and their application in the sensor devices. [10][11][12][13][14][15][16][17][18][19][20] Covalent binding of oligolactic acid to the tetracarboxylic derivatives of p-tert-butylthiacalix [4]arene, which were in three spatial conformations (cone, partial cone and 1,3-alternate) allowed obtaining novel polymer materials for modification of the glassy carbon electrode surface. [21] Compounds synthesized were found to be promising for design of the sensor devices for recognition of some low-molecular biologically relevant analytes.…”