The synthesis of 1,2,4-benzotriazines

Abstract

The 1,2,4-benzotriazine nucleus fused to a benzene ring is a prominent heterocyclic substructure present in numerous pharmacologically active compounds. To date, many 1,2,4-benzotriazine analogues possessing a wide spectrum of potent pharmacological activities are known. This review compiles information on the synthesis, chemical reactions, medicinal chemistry aspects and applications of 1,2,4-benzotriazines.

Eco‐friendly Polyethylene Glycol‐400 as a Rapid and Efficient Recyclable Reaction Medium for the Synthesis of Anticancer Isatin‐linked Chalcones and Their 3‐Hydroxy Precursor

“…Various isatin derivatives exhibit diverse biological activities such as inhibition of the proteasome, antagonizing GHSR, and inhibiting the growth of human cancer cells [4][5][6]. 3-Substituted-3hydroxy-2-oxindoles are the new scaffold for drug discovery [7], which are also versatile intermediates for the synthesis of potential bioactive chalcones [8,9], Isatin chalcones serve as the perfect electron-deficient olefins because of their high reactivity as Michael acceptors [10] and thus are suitable substrates for cycloaddition reactions to generate biologically privileged diverse spirooxindole scaffolds [11,12] (Fig. 1).…”