The synergistic anti-inflammatory effect of the combination of sodium ferulate and oxymatrine and its modulation on inflammation-associated mediators in RAW 264.7 cells

Yuan, Xiaopei; Sun, Yan; Miao, Ningshu; Sun, S L; Wang, Yuyun; Zhao, Haijun; Yuan, Jing; Xu, Mingbo; Liu, Zhifeng

doi:10.1016/j.jep.2011.08.031

Cited by 30 publications

(29 citation statements)

References 22 publications

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“…However, the single drug treatment had a weak anti-inflammatory and analgesic potency. For example, the effective dose of OMT on anti-inflammatory effect was about 100 mg/kg in the animal models [6]. According to prescription of traditional Chinese medicine, we found that the combination of SF and OMT had obvious anti-inflammatory and analgesic effects.…”

Section: Discussionmentioning

confidence: 83%

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The Effects of the Combination of Sodium Ferulate and Oxymatrine on Lipopolysaccharide-Induced Acute Lung Injury in Mice

Yuan

Wang

et al. 2012

Inflammation

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In our previous study, the remarkable analgesic and anti-inflammatory effects of the combination of sodium ferulate (SF) and oxymatrine (OMT) had been found. In this study, we investigated the effect of the combination of SF and OMT on acute lung injury using lipopolysaccharide (LPS)-induced acute lung injury (ALI) mouse model. The cell counting and the protein concentration in the bronchoalveolar lavage fluid (BALF) were measured. The animal lung edema degree was evaluated by wet/dry weight (W/D) ratio. The superoxidase dismutase (SOD) activity and myeloperoxidase (MPO) activity was assayed by SOD and MPO kits, respectively. The levels of inflammatory mediators including C-reactive protein (CRP) and tumor necrosis factor-α (TNF-α) were assayed by enzyme-linked immunosorbent assay method. The data showed that treatment with the combination of SF and OMT markedly attenuated inflammatory cell numbers and protein concentration in the BALF and improved SOD activity and inhibited MPO activity compared to LPS group. Moreover, the combination significantly inhibited the production of CRP and TNF-α in lung homogenate. The histological changes of the lungs were also more significantly improved by the combination. At the same dose, the obvious protective effect was not found in SF or OMT-treated alone group except that the protein concentration slightly decreased in SF group. The results indicated that the combination SF and OMT had a protective effect on LPS-induced ALI in mice, and the effect was much better than that of SF or OMT used alone.

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Section: Discussionmentioning

confidence: 83%

“…In our previous study, the remarkable synergetic analgesic and anti-inflammatory effects of the combination of sodium ferulate (SF) and oxymatrine (OMT) had been found [5,6]. The results showed visible analgesic activity in both mice acetic acid writhing test and rat formalin test after the combination treatment.…”

Section: Introductionmentioning

confidence: 96%

The Effects of the Combination of Sodium Ferulate and Oxymatrine on Lipopolysaccharide-Induced Acute Lung Injury in Mice

Yuan

Wang

et al. 2012

Inflammation

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“…[4][5][6] Oxymatrine significantly ameliorates L-arginine-induced acute pancreatitis by the reduction of plasma amylase, D-lactic acid, tumor necrosis factor alpha concentration, serum diamine oxidase, lipase activity, and pancreatic myeloperoxidase activity. 7 The administration of oxymatrine can significantly inhibit inflammatory responses.…”

Section: Anti-inflammatory Propertiesmentioning

confidence: 98%

“…Combined with sodium ferulate, oxymatrine shows synergistic anti-inflammatory effects. 4 Therefore, oxymatrine plays an important role in anti-inflammatory effects.…”

Section: Anti-inflammatory Propertiesmentioning

confidence: 99%

Oxymatrine and cancer therapy

Zhang

et al. 2015

Eur J Inflamm

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Oxymatrine is a kind of alkaloid extracted from traditional Chinese herb Sophora flavescens Ait. It has been proved to exert various biological activities such as anti-angiogenesis, proliferation-inhibiting, apoptosis-promoting, analgesicstrengthening, and anti-metastasis. The biological activities are related with inhibition of angiogenesis-associated factors, regulation of related signaling pathway and protein expression, synergistic effects with chemotherapy drug, cell cycle arrest and inhibition of voltage-activated K+ channel. In this review, we summarize the recent investigations of oxymatrine in cancer therapy so as to provide references for further study and clinical therapy.

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“…Previous studies revealed that a combination of sodium ferulate and oxymatrine exerted synergistic anti-inflammatory effects (3)(4)(5)(6). The studies demonstrated that sodium ferulate and oxymatrine combination significantly inhibited xylene-induced edema in mouse ears and carrageenan-induced edema in rat paws.…”

Section: Introductionmentioning

confidence: 97%

Anti-exudation effects of sodium ferulate and oxymatrine combination via modulation of aquaporin 1

Sun

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. The present study aimed to investigate the anti-exudative effects of sodium ferulate combined with oxymatrine in a mouse model of acetic acid-induced peritonitis. Furthermore, the underlying mechanisms were explored by determining the effects of these drugs on the volume and aquaporin 1 (AQP1) expression in vascular endothelial cells on omentum majus and human umbilical vein endothelial cells (HUVEC). Treatment with sodium ferulate combined with oxymatrine was shown to significantly inhibit acetic acid-induced vascular permeability in the peritonitis model mice and furthermore to significantly decrease the optical density of Evans blue, the leukocyte number and the levels of interleukin-6, C-reactive protein and interferon-γ in peritoneal lavage fluid. Pathological analysis of the omentum majus revealed that sodium ferulate and oxymatrine combination treatment significantly alleviated vascular endothelial cell edema and capillary loss. In vitro, flow cytometry revealed that the volume of HUVECs was significantly reduced in the drug treatment groups, as reflected in the forward scatter value. The optical density of AQP1 on the membrane of the vascular endothelial cells on omentum majus and HUVECs were significantly increased in the drug treatment groups compared with the model group. These results indicated that sodium ferulate and oxymatrine combination treatment possessed prominent anti-exudative effects and that the underlying mechanisms are likely to include the improvement of vascular endothelial cellular edema, possibly by upregulation of AQP1 expression on their membrane, which requires further exploration.

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The synergistic anti-inflammatory effect of the combination of sodium ferulate and oxymatrine and its modulation on inflammation-associated mediators in RAW 264.7 cells

Cited by 30 publications

References 22 publications

The Effects of the Combination of Sodium Ferulate and Oxymatrine on Lipopolysaccharide-Induced Acute Lung Injury in Mice

The Effects of the Combination of Sodium Ferulate and Oxymatrine on Lipopolysaccharide-Induced Acute Lung Injury in Mice

Oxymatrine and cancer therapy

Anti-exudation effects of sodium ferulate and oxymatrine combination via modulation of aquaporin 1

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