The Effects of the Combination of Sodium Ferulate and Oxymatrine on Lipopolysaccharide-Induced Acute Lung Injury in Mice

Yuan, Xiaopei; Wang, Yuyun; Du, Dunren; Zhao, Haijun; Xu, Mengxin; Xu, Mingbo; Liu, Zhifeng

doi:10.1007/s10753-011-9424-3

Cited by 22 publications

(20 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Inflammatory cell infiltration is induced by influenza virus into lung tissues, causing the release of proinflammatory cytokines such as IL-1β, chemotactic factors and TNF-α [3,4]. These changes cause lung edema, alveolar hemorrhage, and overwhelming inflammation [35]. In the present study, we found that 1,8-cineol attenuated influenza virus-induced lung inflammation.…”

Section: Discussionsupporting

confidence: 59%

1, 8-Cineol Protect Against Influenza-Virus-Induced Pneumonia in Mice

Lai

Wang

et al. 2016

Inflammation

View full text Add to dashboard Cite

1,8-Cineol is a major monoterpene principally from eucalyptus essential oils and has been shown to exert anti-inflammatory, antiviral, and inhibitory of nuclear factor (NF)-kB effect. In the present study, we evaluated the effect of 1,8-cineol on mice infected with influenza A virus. We found that 1,8-cineol protects against influenza viral infection in mice. Moreover, 1,8-cineol efficiently decreased the level of IL-4, IL-5, IL-10, and MCP-1 in nasal lavage fluids and the level of IL-1β, IL-6, TNF-α, and IFN-γ in lung tissues of mice infected with influenza virus. The results also showed that 1,8-cineol reduced the expression of NF-kB p65, intercellular adhesion molecule (ICAM)-1, and vascular cell adhesion molecule (VCAM)-1 in lung tissues. Thus, 1,8-cineol appears to be able to augment protection against IFV infection in mice via attenuation of pulmonary inflammatory responses.

show abstract

Section: Discussionsupporting

confidence: 59%

1, 8-Cineol Protect Against Influenza-Virus-Induced Pneumonia in Mice

Lai

Wang

et al. 2016

Inflammation

View full text Add to dashboard Cite

show abstract

“…Treatment with sodium feulate and oxymatrine combination also significantly decreased the leukocyte number as well as the levels of IL-6, CRP and IFN-γ in the peritoneal lavage fluid induced by acetic acid, and its effect was better than that of each drug alone at doses equal to those in the medium combined group, which verified the results of previous studies by our group, which reported that sodium ferulate and oxymatrine combination significantly reduced the levels of IL-6, CRP and IFN-γ in serum or tissue homogenate of other mouse models (5,6,23). IL-6, a pro-inflammatory cytokine, has a vital role in the process of inflammation and macrophage activation (26)(27)(28).…”

Section: Fsc-supporting

confidence: 87%

“…Among them, inflammatory exudation and cellular edema are major pathophysiological characteristics in the early phase of the inflammatory response meaning acute inflammation, and usually lead to vulnerability to organ damage such as acute lung edema and peritonitis (22). Previous studies by our group found that sodium ferulate and oxymatrine combination significantly alleviate the acute inflammatory response (23). Based on a comprehensive analysis of these results, it was hypothesized that the drug may have a significant anti-exudation effect.…”

Section: Discussionmentioning

confidence: 99%

Anti-exudation effects of sodium ferulate and oxymatrine combination via modulation of aquaporin 1

Sun

et al. 2017

Experimental and Therapeutic Medicine

Self Cite

View full text Add to dashboard Cite

Abstract. The present study aimed to investigate the anti-exudative effects of sodium ferulate combined with oxymatrine in a mouse model of acetic acid-induced peritonitis. Furthermore, the underlying mechanisms were explored by determining the effects of these drugs on the volume and aquaporin 1 (AQP1) expression in vascular endothelial cells on omentum majus and human umbilical vein endothelial cells (HUVEC). Treatment with sodium ferulate combined with oxymatrine was shown to significantly inhibit acetic acid-induced vascular permeability in the peritonitis model mice and furthermore to significantly decrease the optical density of Evans blue, the leukocyte number and the levels of interleukin-6, C-reactive protein and interferon-γ in peritoneal lavage fluid. Pathological analysis of the omentum majus revealed that sodium ferulate and oxymatrine combination treatment significantly alleviated vascular endothelial cell edema and capillary loss. In vitro, flow cytometry revealed that the volume of HUVECs was significantly reduced in the drug treatment groups, as reflected in the forward scatter value. The optical density of AQP1 on the membrane of the vascular endothelial cells on omentum majus and HUVECs were significantly increased in the drug treatment groups compared with the model group. These results indicated that sodium ferulate and oxymatrine combination treatment possessed prominent anti-exudative effects and that the underlying mechanisms are likely to include the improvement of vascular endothelial cellular edema, possibly by upregulation of AQP1 expression on their membrane, which requires further exploration.

show abstract

“…Oxymatrine (OM), is a kind of alkaloid components found in the roots of sophora species, had been reported to have many pharmacological effects, such as anti-inflammation, anti-virus, anti-fibrotic, anti-allergic and protecting hepatocytes and cardiovascular [7][8][9]. In previous studies, the effects of oxymatrine on human lung cancer are largely unknown.…”

Section: Introductionmentioning

confidence: 99%

Oxymatrine inhibited cell proliferation by inducing apoptosis in human lung cancer A549 cells

Wang

Han

Zhu

2015

BME

View full text Add to dashboard Cite

Abstract.To investigate the inhibition effect of oxymatrine induces human lung cancer A549 cells apoptosis. The A549 cells were cultured for 24 h, than the various concentration of oxymatrine (2 mmol/L, 4 mmol/L, 8 mmol/L, 15 mmol/L) were added into different experimental group cells, and 5-fluorouracil were added into the positive control group cells for 12 h, 24 h, 36 h, 48 h respectively. The A549 cells inhibition rate, apoptosis, and the expression of Bcl-2 and Bax were examined by MTT method, Annexin /PI double staining method, real-time quantitative PCR and western blot, respectively. At same time, the morphological changes of A549 cells were observed with an inverted microscope. In the range of 2 mmol/L~15 mmol/L, oxymatrine had obvious inhibition effects on the proliferation of A549 cells. Compared with the negative control group, it has significantly different (P<0.01). There was remarkably the time-and dose-dependent correlation. After A549 cells were treated with 8 mmol/L oxymatrine for 24 h, the morphological change of cell apoptosis was observed and the extent of apoptosis was quantified by flow cytometry. Furthermore, the expression of Bcl-2 was reduced and the expression of Bax was increased remarkably (P<0.05). Oxymatrine has significant inhibition effects on the cells proliferation and the effects showed time-dependent and dose-dependent. Oxymatrine can induce apoptosis of the A549 cells by regulating the expression of Bcl-2 and Bax.

show abstract

The Effects of the Combination of Sodium Ferulate and Oxymatrine on Lipopolysaccharide-Induced Acute Lung Injury in Mice

Cited by 22 publications

References 18 publications

1, 8-Cineol Protect Against Influenza-Virus-Induced Pneumonia in Mice

1, 8-Cineol Protect Against Influenza-Virus-Induced Pneumonia in Mice

Anti-exudation effects of sodium ferulate and oxymatrine combination via modulation of aquaporin 1

Oxymatrine inhibited cell proliferation by inducing apoptosis in human lung cancer A549 cells

Contact Info

Product

Resources

About