The Swiss Perimenopause Study – study protocol of a longitudinal prospective study in perimenopausal women

Willi, Jürg; Süss, Hannah; Ehlert, Ulrike

doi:10.1186/s40695-020-00052-1

Cited by 10 publications

(7 citation statements)

References 75 publications

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“…Mulhall et al (2018) reported an increase in women's depressive symptoms during the menopausal transition. This result is consistent with the literature (Marvan et al, 2018; Willi et al, 2020) and shows that the severity of depressive symptoms increases with menopausal symptoms. Psychoeducational programs, health education, and counseling have also been determined to be an essential implementation for women with menopausal symptoms (NAMS, 2017).…”

Section: Discussionsupporting

confidence: 93%

Assessment of depression and sexual quality of life in postmenopausal women

Düzgün

Kök

Şahin

et al. 2022

Perspect Psychiatric Care

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Purpose: To determine the prevalence of depression, review some variables that are believed to be associated and assess the relationships between depression and sexual quality of life in postmenopausal women.Design and Methods: This is a cross-sectional study conducted on postmenopausal women in Ankara, Turkey from February to June 2020. The study group consisted of 242 postmenopausal women. The Beck Depression Inventory and Sexual Quality of Life Questionnaire were used to assess the level of depression and sex life, respectively. Online questionnaire forms (Google Form) prepared by using the literature in line with the study objective were completed by the women online. Independent t-test, analysis of variance, Tukey's test, and Pearson's correlation analysis were used for statistical analyses. Statistical significance was accepted as p ≤ 0.05. Findings:The of women was found to be 52.64 (±6.245) years and the average menopause age was found to be 47.81 (±4.039) years in this study. The mean score obtained by the women from the Beck Depression Inventory was 13.04 (±7.82). It was determined that the women showed "mild depressive symptoms" mostly. As for the women's sexual quality of life, the mean score obtained from the Sexual Quality of Life Questionnaire was 61.32 (±14.70). A statistically significant and moderate negative correlation was detected between the mean scores obtained by the women from the Beck Depression Inventory and the Sexual Quality of Life Questionnaire (r = −0.305; p < 0.01).Practice Implications: It was determined in the study that sexual quality of life is affected by menopause negatively and the women had mild depressive symptoms.Depression among postmenopausal women is an important women's health problem that should be addressed. A negative correlation was found between depression and sexual quality of life. Early diagnosis and treatment of menopause as well as activities for raising awareness among postmenopausal women will be effective in improving quality of life.

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Section: Discussionsupporting

confidence: 93%

Assessment of depression and sexual quality of life in postmenopausal women

Düzgün

Kök

Şahin

et al. 2022

Perspect Psychiatric Care

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“…28 Premenopausal and menopausal women experience phases of large hormonal fluctuations in estradiol and progesterone levels, which has been shown to correlate with physical and psychological symptoms and has been referred to as "complaints of menopause" in several studies. 29 At the social level, this has been suggested to influence the development of a negative attitude towards menopause, which can be associated with a lower perception of social support as compared to men. 30 In the present study, social support did not show a significant relationship with adherence to treatment in any of the groups.…”

Section: Discussionmentioning

confidence: 99%

The Relationship Between Psychosocial Factors and Adherence to Treatment in Men, Premenopausal and Menopausal Women with Type 2 Diabetes Mellitus

Florez¹,

Aquilera²,

Roca-Chiapas³

et al. 2021

PRBM

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Introduction Type 2 Diabetes Mellitus (T2DM) is a chronic disease that begins in adulthood, and is caused by multiple factors. The onset of menopause involves changes that predispose women to the development of T2DM, which can worsen if the adherence to treatment is inadequate due to psychosocial factors or medications. The present study aims to describe the psychosocial factors that may affect adherence to treatment among men and premenopausal and menopausal women with T2DM. Methods This was a cross-sectional study of 96 patients with T2DM, who were divided into three groups: 1) men (n=32); 2) premenopausal women (n=32); and 3) menopausal women (n=32). Somatometric and metabolic control data were obtained. Adherence to treatment and psychosocial factors were evaluated: social support, belief in conventional medicine, disease denial, and depressive symptoms. Results Adherence to medication had a negative correlation with depressive symptoms in men (p <0.001) and menopausal women (p <0.021). Dietary adherence had a positive correlation with belief in conventional medicine in men (p <0.037) and premenopausal women (p <0.029). Conclusion Medication adherence in men and menopausal women was correlated with fewer depressive symptoms. Adherence to diet in men and premenopausal women was correlated with greater belief in conventional medicine. The results show the diversity of psychosocial factors among the groups that must be addressed in order to improve adherence.

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“…One central aim of the project was to measure and analyze a variety of biopsychosocial factors associated with menopausal transition over time. The present study is a longitudinal investigation of steroid hormone secretion patterns throughout all biological assessment points, namely during months 2, 7, and 12 [for a detailed description of the study protocol, see ( 12 )].…”

Section: Methodsmentioning

confidence: 99%

“…Month 2 represents the initial start of sample collection for participants, while month 12 represents the end of study participation. For the assessment of endocrine parameters in the middle of study participation, month 7 was chosen for endocrine analyses [for a detailed description of the study protocol, see ( 12 )]. All measurement time points were standardized for all participants regardless of their menopausal stage.…”

Section: Methodsmentioning

confidence: 99%

Steroid Hormone Secretion Over the Course of the Perimenopause: Findings From the Swiss Perimenopause Study

Grub

Süss

Willi

et al. 2021

Front. Glob. Womens Health

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Background: Perimenopause is characterized by a decline in the steroid hormones, estradiol, and progesterone. By contrast, the steroid hormone cortisol, a marker of the hypothalamic–pituitary–adrenal (HPA) axis, increases. Recent longitudinal studies reported fluctuations in steroid hormone levels during perimenopause, and even increases in estradiol levels. To understand these confounding results, it is necessary to conduct a longitudinal, highly standardized assessment of steroid hormone secretion patterns in perimenopausal women.Methods: This longitudinal study investigated 127 perimenopausal women aged 40–56 years for 13 months. Estradiol, progesterone, and cortisol were assessed using saliva samples, which were collected for two (during months 2 and 12 for estradiol and progesterone) or three (during months 2, 7, and 12 for cortisol) non-consecutive months over the course of the study. A total of 14 saliva samples per participant were analyzed to investigate the courses of estradiol and progesterone. Cortisol awakening response and fluctuations of cortisol throughout the day were measured using a total of 11 saliva samples per participant (on awakening, +30 min, +60 min, at 12:00 p.m., and before going to bed) for months 2, 7, and 12.Results: Multilevel analyses revealed variance in intercept and slope across participants for estradiol [intercept: SD = 5.16 (95% CI: 4.28, 6.21), slope: SD = 0.50 (95% CI: 0.39, 0.64)], progesterone [intercept: SD = 34.77 (95% CI: 25.55, 47.31), slope: SD = 4.17 (95% CI: 2.91, 5.99)], and cortisol (intercept: SD = 0.18 (95% CI: 0.14, 0.23), slope: SD = 0.02 (95% CI: 0.01, 0.02)]. Time predicted cortisol levels [b = −0.02, t(979) = −6.63, p < 0.0001]. Perimenopausal status (early vs. late) did not predict estradiol [b = −0.36, t(1608) = −0.84, p = 0.400], progesterone [b = −4.55, t(1723) = −0.87, p = 0.385], or cortisol [b = 0.01, t(1124) = 0.61, p = 0.542] scores over time.Discussion: Our results are consistent with previous findings emphasizing highly individual fluctuations of estradiol and progesterone levels during perimenopause. However, our findings do not suggest a continuous decline during the observed transition phase, implying relatively stable periods of fluctuating hormone levels. Furthermore, given the lack of significant group differences, it may not be necessary to differentiate between early and late perimenopause from the standpoint of hormonal progression.

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The Swiss Perimenopause Study – study protocol of a longitudinal prospective study in perimenopausal women

Cited by 10 publications

References 75 publications

Assessment of depression and sexual quality of life in postmenopausal women

Assessment of depression and sexual quality of life in postmenopausal women

The Relationship Between Psychosocial Factors and Adherence to Treatment in Men, Premenopausal and Menopausal Women with Type 2 Diabetes Mellitus

Steroid Hormone Secretion Over the Course of the Perimenopause: Findings From the Swiss Perimenopause Study

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