The sulfonated polyetheretherketone with 3D structure modified by two bio-inspired methods shows osteogenic and antibacterial functions

Sang, Shang; Yang, Chao; Chai, Haobo; Yuan, Xiangwei; Liu, Wei; Zhang, Xianlong

doi:10.1016/j.cej.2021.130059

Cited by 21 publications

(13 citation statements)

References 57 publications

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“…In our previous study, after sulfonated surface modification of PEEK, its overall mechanical properties were maintained, and its 3D porous structure could be used as a drug carrier. 43,44 In this study, we loaded ICA on the SPEEK via PDA adhesion. The modified ICA-PDA@SPEEK achieved the sustained and stable release of ICA over a long period of time, and the concentration of ICA in the medium was about 10 −5 M, which was also the most suitable concentration for icariin to exert immunomodulatory effect.…”

Section: Discussionmentioning

confidence: 99%

Icariin-loaded sulfonated polyetheretherketone with osteogenesis promotion and osteoclastogenesis inhibition properties via immunomodulation for advanced osseointegration

et al. 2022

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Section: Discussionmentioning

confidence: 99%

Icariin-loaded sulfonated polyetheretherketone with osteogenesis promotion and osteoclastogenesis inhibition properties via immunomodulation for advanced osseointegration

et al. 2022

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“…Silk was another alternative to obtain a sustained release of gentamicin. When the combination was coated on SrCO 3 -PDAmodified PEEK, it significantly improved the antibacterial effect of PEEK and sulfonated PEEK [142]. Nano magnesium silicate was an alternative bioactive ceramic material to load a natural antibacterial compound, curcumin [134].…”

Section: Coating With a Drug Carrier Materialsmentioning

confidence: 99%

Methods to improve antibacterial properties of PEEK: A review

Uysal,

Tezcaner,

Evis

2024

Biomed. Mater.

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As a thermoplastic and bioinert polymer, polyether ether ketone (PEEK) serves as spine implants, femoral stems, cranial implants, and joint arthroplasty implants due to its mechanical properties resembling the cortical bone, chemical stability, and radiolucency. Although there are standards and antibiotic treatments for infection control during and after surgery, the infection risk is lowered but can not be eliminated. The antibacterial properties of PEEK implants should be improved to provide better infection control. This review includes the strategies for enhancing the antibacterial properties of PEEK in four categories: immobilization of functional materials and functional groups, forming nanocomposites, changing surface topography, and coating with antibacterial material. The measuring methods of antibacterial properties of the current studies of PEEK are explained in detail under quantitative, qualitative, and in vivo methods. The mechanisms of bacterial inhibition by reactive oxygen species (ROS) generation, contact killing, trap killing, and limited bacterial adhesion on hydrophobic surfaces are explained with corresponding antibacterial compounds or techniques. The prospective analysis of the current studies is done, and dual systems combining osteogenic and antibacterial agents immobilized on the surface of PEEK are found the promising solution for a better implant design.

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“…Subsequently, they loaded a layer of silk protein-gentamicin coating on the SPEEK material to endow it with antibacterial ability. This provided innovative inspiration for developing novel functional orthopedic implants, such as antibacterial and antiloose implants [ 165 ].…”

Section: Applications Of Bioinspired Antibacterial Surfacesmentioning

confidence: 99%

Recent Progress on Bioinspired Antibacterial Surfaces for Biomedical Application

et al. 2022

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Surface bacterial fouling has become an urgent global challenge that calls for resilient solutions. Despite the effectiveness in combating bacterial invasion, antibiotics are susceptible to causing microbial antibiotic resistance that threatens human health and compromises the medication efficacy. In nature, many organisms have evolved a myriad of surfaces with specific physicochemical properties to combat bacteria in diverse environments, providing important inspirations for implementing bioinspired approaches. This review highlights representative natural antibacterial surfaces and discusses their corresponding mechanisms, including repelling adherent bacteria through tailoring surface wettability and mechanically killing bacteria via engineering surface textures. Following this, we present the recent progress in bioinspired active and passive antibacterial strategies. Finally, the biomedical applications and the prospects of these antibacterial surfaces are discussed.

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The sulfonated polyetheretherketone with 3D structure modified by two bio-inspired methods shows osteogenic and antibacterial functions

Cited by 21 publications

References 57 publications

Icariin-loaded sulfonated polyetheretherketone with osteogenesis promotion and osteoclastogenesis inhibition properties via immunomodulation for advanced osseointegration

Icariin-loaded sulfonated polyetheretherketone with osteogenesis promotion and osteoclastogenesis inhibition properties via immunomodulation for advanced osseointegration

Methods to improve antibacterial properties of PEEK: A review

Recent Progress on Bioinspired Antibacterial Surfaces for Biomedical Application

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