Recent Progress on Bioinspired Antibacterial Surfaces for Biomedical Application

Abstract

Surface bacterial fouling has become an urgent global challenge that calls for resilient solutions. Despite the effectiveness in combating bacterial invasion, antibiotics are susceptible to causing microbial antibiotic resistance that threatens human health and compromises the medication efficacy. In nature, many organisms have evolved a myriad of surfaces with specific physicochemical properties to combat bacteria in diverse environments, providing important inspirations for implementing bioinspired approaches. This review highlights representative natural antibacterial surfaces and discusses their corresponding mechanisms, including repelling adherent bacteria through tailoring surface wettability and mechanically killing bacteria via engineering surface textures. Following this, we present the recent progress in bioinspired active and passive antibacterial strategies. Finally, the biomedical applications and the prospects of these antibacterial surfaces are discussed.

Fabrication of a Polycaprolactone/Chitosan Nanofibrous Scaffold Loaded with Nigella sativa Extract for Biomedical Applications

“…The antibacterial action of N. sativa seed extract may cause bacterial cell membranes to become permeable, resulting in cell destabilization and death [ 65 ]. Gram-negative bacteria are more resistant because their cell membranes are double-layered, as opposed to Gram-positive bacteria’s single-layer membranes [ 66 , 67 ].…”

Multi-functional approach in the design of smart surfaces to mitigate bacterial infections: a review

“…In this milieu, surface roughness in terms of nano-topography is the most critical parameter to attain antifouling or bactericidal properties, and surface nanoroughness ranging from 30 nm to 1 μm efficiently reduces the attachment of bacteria ( Medilanski et al., 2002 ; Fröjd et al., 2011 ; Bazaka et al., 2015 ). Various nano or micro topographical modifications for next-generation medical device surfaces have been explored, including micro/nanopores, micro ridges, micro/nanopillars, nanocolumns, nanocolumns, nanowires, nanorings, nanospinules or hairs, and nano spikes/needles ( Reddy et al., 2011 ; Tripathy et al., 2017 ; Yang et al., 2022 ). The interaction between the substrate topographies and bacteria leads to bacterial killing or preventing bacterial adherence and circumvents biofilm formation, mitigating AMR ( Feng et al., 2015 ; Khalid et al., 2020 ).…”

Black silicon spacing effect on bactericidal efficacy against gram-positive bacteria

“…Antibacterial surfaces are essential to reduce infections and illness in a wide variety of applications such as medical devices, sutures, contact lens cases, dental implants, and catheters [1][2][3][4][5][6][7][8][9][10][11] as well as everyday household items such as kitchen and bathroom surfaces, appliances, consumer products, health club equipment, and food packaging [12][13][14]. Surfaces that are antiviral are also of much interest for these applications [15][16][17].…”