Icariin-loaded sulfonated polyetheretherketone with osteogenesis promotion and osteoclastogenesis inhibition properties <i>via</i> immunomodulation for advanced osseointegration

Chai, Haobu; Sang, Shang; Luo, Yao; He, Renke; Yuan, Xiangwei; Zhang, Xianlong

doi:10.1039/d1tb02802b

Cited by 17 publications

(10 citation statements)

References 65 publications

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“…The mass spectrometry conditions were as follows: Electrospray ionization (ESI) was used to collect data in positive and negative ion modes. The desolvation gas flow was 800 L h À1 , the desolvation temperature was 450 1C, the cone gas flow was 50 L h À1 , the source temperature was 120 1C, the positive ion capillary voltage was 3 kV, the negative ion capillary voltage was 3 kV, the sampling cone voltage was 40 V, the scanning mode was full scan, and the scanning range was m/z 150-2000 for MS 1 and m/z 100-1800 for MS 2 . The software Peakview was used to analyze mass spectrometry data.…”

Section: Lc-ms Analysis Methodsmentioning

confidence: 99%

“…was first recorded in the text Shen Nong's Herbal Classic, which has been used for more than 2000 years. [1][2][3] Currently, there are about 40 species of Epimedium in the world, and 8 species of Epimedium medicinal herbs circulating in the market, including Epimedium koreanum Nakai, Epimedium brevicornum Maxim., Epimedium pubescens Maxim., Epimedium sagittatum (Sieb. et Zucc.)…”

Section: Introductionmentioning

confidence: 99%

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Quality differentiation of Epimedium from different harvesting periods based on LC-MS and network pharmacology

Zhang,

Chen,

Tang

et al. 2024

New J. Chem.

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Section: Lc-ms Analysis Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Quality differentiation of Epimedium from different harvesting periods based on LC-MS and network pharmacology

Zhang,

Chen,

Tang

et al. 2024

New J. Chem.

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“…Experimental findings demonstrated that the developed scaffolds effectively loaded and released ICA over an extended period. Furthermore, various biomaterials have been investigated to enhance the loading efficiency and bioavailability of ICA, including β-TCP [ 145 ], PLGA [ 146 ], calcium phosphate cement [ 147 ], 3D porous polydopamine/sulfonated PEEK [ 148 ], TiO 2 nanotube/PLGA [ 149 ], titanium [ 150 , 151 ], PCL/gelatin fibers [ 152 ], SF/PLCL nanofibrous scaffold [ 153 ], PLLA/PDA/chitosan [ 154 ], biphasic calcium phosphate (BCP) [ 155 ], polyvinyl alcohol (PVA)/β-TCP [ 156 ], hydroxyapatite/chitosan [ 157 ], hydroxyapatite/alginate porous composite [ 139 ], nanohydroxyapatite/polylactic acid (nHAP/PLA) [ 158 ], and PLGA/β-TCP [ 140 ].…”

Section: Icariin-loaded Nanoplatformsmentioning

confidence: 99%

Promoting osteogenesis and bone regeneration employing icariin-loaded nanoplatforms

Mohammadzadeh,

Zarei,

Abbasi

et al. 2024

J Biol Eng

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There is an increasing demand for innovative strategies that effectively promote osteogenesis and enhance bone regeneration. The critical process of bone regeneration involves the transformation of mesenchymal stromal cells into osteoblasts and the subsequent mineralization of the extracellular matrix, making up the complex mechanism of osteogenesis. Icariin’s diverse pharmacological properties, such as anti-inflammatory, anti-oxidant, and osteogenic effects, have attracted considerable attention in biomedical research. Icariin, known for its ability to stimulate bone formation, has been found to encourage the transformation of mesenchymal stromal cells into osteoblasts and improve the subsequent process of mineralization. Several studies have demonstrated the osteogenic effects of icariin, which can be attributed to its hormone-like function. It has been found to induce the expression of BMP-2 and BMP-4 mRNAs in osteoblasts and significantly upregulate Osx at low doses. Additionally, icariin promotes bone formation by stimulating the expression of pre-osteoblastic genes like Osx, RUNX2, and collagen type I. However, icariin needs to be effectively delivered to bone to perform such promising functions.Encapsulating icariin within nanoplatforms holds significant promise for promoting osteogenesis and bone regeneration through a range of intricate biological effects. When encapsulated in nanofibers or nanoparticles, icariin exerts its effects directly at the cellular level. Recalling that inflammation is a critical factor influencing bone regeneration, icariin's anti-inflammatory effects can be harnessed and amplified when encapsulated in nanoplatforms. Also, while cell adhesion and cell migration are pivotal stages of tissue regeneration, icariin-loaded nanoplatforms contribute to these processes by providing a supportive matrix for cellular attachment and movement. This review comprehensively discusses icariin-loaded nanoplatforms used for bone regeneration and osteogenesis, further presenting where the field needs to go before icariin can be used clinically.

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“…Ouyang et al have demonstrated that sulfonated PEEK exhibited significant antibacterial properties against Staphylococcus aureus and Escherichia coli. The high specific surface area and roughness of the 3D porous network make it an ideal carrier for functional biomolecules, thus endowing it with additional biological functions. − Moreover, several studies have indicated that the 3D interconnected porous network can be used as a drug delivery platform, offering the possibility of achieving stable and slow drug release. − …”

Section: Introductionmentioning

confidence: 99%

The Formation Process and Mechanism of the 3D Porous Network on the Sulfonated PEEK Surface

Xie,

Xiao,

Song

et al. 2024

ACS Appl. Mater. Interfaces

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A three-dimensional (3D) porous network can be prepared on the PEEK surface by sulfonation with enhanced osseointegration and antibacterial properties. However, few studies have been conducted on the formation mechanism of a 3D porous network. In this work, the surface and cross-sectional morphologies, chemical compositions, functional groups, surface wettability, and crystalline states of sulfonated PEEK were investigated at different sulfonation times and coagulant concentrations. The results show that the number of nodular structures and broken fibers on the sulfonated PEEK surface as well as the size of macrovoids in the cross sections increase with increasing sulfonation times when water is used as a coagulant. In contrast, dilute sulfuric acid as a coagulant can inhibit the formation of surface porous structures and macrovoids in the cross sections. Moreover, all of the sulfonated PEEK samples have the same chemical compositions but exhibit better hydrophilicity as the number of microsized pores decreases. It is proposed that non-solvent-induced phase separation (NIPS) occurs during the sulfonation process, and the formation mechanism of surface and cross-sectional morphologies is discussed. Furthermore, it is assumed that the air is trapped in the microsized pores, leaving the surface of the 3D porous network in the Cassie-wetting state. All of these preliminary results throw light on the nature of the sulfonation process and may guide further modification of the structures of sulfonated PEEK.

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Icariin-loaded sulfonated polyetheretherketone with osteogenesis promotion and osteoclastogenesis inhibition properties via immunomodulation for advanced osseointegration

Abstract: Preventing prosthesis loosening due to insufficient osseointegration is critical for patients with osteoporosis. Endowing implants with immunomodulatory function can effectively enhance osseointegration. In this work, we loaded icariin (ICA) onto...

Cited by 17 publications

References 65 publications

Quality differentiation of Epimedium from different harvesting periods based on LC-MS and network pharmacology

Quality differentiation of Epimedium from different harvesting periods based on LC-MS and network pharmacology

Promoting osteogenesis and bone regeneration employing icariin-loaded nanoplatforms

The Formation Process and Mechanism of the 3D Porous Network on the Sulfonated PEEK Surface

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