The Study on Long-Term Toxicity of D-Psicose in Rats

Yagi, Kanako; Matsuo, Tatsuhiro

doi:10.3164/jcbn.08-191

Cited by 57 publications

(60 citation statements)

References 23 publications

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“…In addition, kidney weight was significantly higher in the MGS group than in the RSS group. In our previous sub-chronic toxicity study using rats, administration of d-allulose at the level of 3% in the diet also showed weight gain of the liver and kidneys, but did not show any adverse health effects (29). Since, similar to d-tagatose, hepatic glycogen accumulation induced by d-allulose has been reported (10), enlarged liver is likely to be due to increased glycogen content.…”

Section: Resultsmentioning

confidence: 99%

Comparison of Anti-Obesity Effect between Two Types of Syrup Containing Rare Sugars in Wistar Rats

Ochiai

Misaki

Yamada

et al. 2017

J Nutr Sci Vitaminol

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Summary d-Allulose-containing rare sugar sweeteners have been categorized into two types, rare sugar syrup (RSS), consisting of 4 rare monosaccharides, and modified glucose syrup (MGS), rich in d-allulose, which was previously referred to d-psicose. The anti-obesity effect of RSS and d-allulose has been already clarified, but that of rare monosaccharides other than d-allulose in RSS has not yet been well understood. Here, we investigated and compared the anti-obesity effect of RSS and MGS in rats. Male Wistar rats were divided into 4 dietary groups: a high-sucrose control diet group (S), a high-fructose corn syrup diet group (HFCS), an RSS diet group (RSS), and an MGS diet group (MGS). RSS significantly suppressed abdominal adipose tissue weight and total body fat accumulation in comparison to sucrose. On the other hand, MGS reduced body weight gain, but not abdominal fat accumulation, relative to sucrose. The weight of the liver and kidneys was significantly higher in the RSS and MGS groups than in the S and HFCS groups, but serum biochemical parameters and hepatic lipids contents were not significantly different among the groups. The present study shows that two types of d-allulose-containing rare sugar sweeteners can suppress body fat accumulation or weight gain in a different manner and that RSS could be used as more effective sweeteners in place of sucrose and HFCS to maintain healthy body weight.

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Section: Resultsmentioning

confidence: 99%

Comparison of Anti-Obesity Effect between Two Types of Syrup Containing Rare Sugars in Wistar Rats

Ochiai

Misaki

Yamada

et al. 2017

J Nutr Sci Vitaminol

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“…The rats were randomly divided into two groups of 10 (control and PS groups). We adopted Dpsicose as a control for PS because the safety of D-psicose was confirmed by our previous studies in animals and humans [11,[14][15][16]. The compositions of experimental diets are shown in Table 1.…”

Section: Animals and Experimental Dietsmentioning

confidence: 98%

“…We have examined the effects of acute [11], sub-chronic (90 days) [15], and long-term feeding (12 -18 months) [14] of D-psicose to rats prior to its utilization as a physiologically functional food. We concluded that a small amount of D-psicose in the diet had no adverse effects in rats.…”

Section: Discussionmentioning

confidence: 99%

“…As a result, most people ingest a limited amount of D-psicose on a daily basis. Furthermore, we examined the effects of sub-chronic (90 days) and long-term feeding (12 -18 months) of D-psicose to rats prior to its utilization as a physiologically functional food [14,15]. We showed that 3% D-psicose in the diet had no adverse effects in rats.…”

Section: Introductionmentioning

confidence: 99%

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The effects of 90-day feeding of D-psicose syrup in male wistar rats

Matsuo¹,

Ishii²,

Shirai³

2011

OJPM

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D-Psicose is a rare sugar present in small quantities in natural products. In a previous study, we showed that D-psicose suppresses increase in plasma glucose and reduces body fat accumulation in rats. Based on acute and chronic toxicity testing in rats, D-psicose is classified as an ordinary and safe substance. Recently, we developed a high D-psicose syrup (PS) made from high fructose corn syrup (HFCS) by the alkaline isomerization method. However, the safety of PS as a food additive has not been demonstrated. In this study, we investigated the effects of 90-day feeding of PS in male Wistar rats. The rats were fed diets containing 3% D-psicose (control) or 4.3% PS for 90 days. The body weight gain and intra-abdominal adipose tissue weight did not differ between the control and PS group. The weights of the tissues did not differ between the two dietary groups. In clinical chemistry and hematological analyses, no differences were found between the control and PS groups. No gross pathological findings were evident at dietary doses of 4.3% PS. Therefore, the present study found no adverse effects of PS in rats fed a diet containing 4.3% PS for 90 days.

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“…The amount test carbohydrate was decided by reference to previous studies of sucralose and D-psicose. 9,11) Body weight gain and food intake were recorded every day. After 6 months, the rats were fasted overnight from 22:00 h, and then sacrificed by exsanguinity under anesthetization with intraperitoneal sodium pentobarbital.…”

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confidence: 99%