The Structure of the Liver Sinusoids and the Sinusoidal Cells

Aterman, K.

doi:10.1016/b978-1-4832-2824-2.50009-1

Cited by 32 publications

(12 citation statements)

References 79 publications

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“…The cells examined in the present study are similar to those described under various names: interstitial cells, Ito cells, fat-storing cells, lipocytes (2,4,9,19,22). The number of lipocytes which we have found is compar able to the number reported (1 lipocyte for 20 hepatocytes) in a semi-quantitative study of a group of 25 normal subjects (4) but higher than the values reported by others (6) in a group of psoriatic patients.…”

Section: Discussionsupporting

confidence: 58%

The Lipocytes in Normal Human Liver

1981

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A quantitative analysis of lipocytes (fat-storing cells, Ito cells) has been conducted on needle liver biopsies of 8 subjects without hepatic impairment. The mean volume density of lipocytes was 1.88 ± 0.25% of parenchymal volume, and the number of lipocytes per 1,000 hepatocytes (Ito cell index) was 63.45 ± 19.18. A study of the zonal distribution showed that the values were significantly higher in the centrolobular than in the periportal areas. No correlation was evident between the volume density or the number of lipocytes and the volume density of parenchymal steatosis. The high coefficients of variation resulting from the present study are evidence that quantitative data are necessary to evaluate volumetrical or numerical variations of lipocytes.

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Section: Discussionsupporting

confidence: 58%

The Lipocytes in Normal Human Liver

1981

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“…The maximal hepatic extraction of BSP (E) may be derived from Equation 3 as: [5] for both man and dog when a is taken as 1.23 X 10-5 ml per second per cm2 of sinusoidal surface area; D, as 3 x 10-6 cm2 per second, from the molecular weight of BSP and the Einstein equation; K, as 7.7 x 105 for a plasma albumin concentration of 5 g per 100 ml; and x, as 10-4 cm, the combined thickness of the endothelial cells and the perisinusoidal space (20). Even when due allowance is made for probable species differences and errors in anatomical measurements, this value for E contrasts strikingly with values as high as 0.915 reported in man (21) and 0.50 in the dog (17).…”

Section: Discussionmentioning

confidence: 99%

Binding of sulfobromophthalein (BSP) sodium by plasma albumin. Its role in hepatic BSP extraction.

Baker¹,

Bradley²

1966

J. Clin. Invest.

140

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“…ATERMAN (1963) actually described that the distinction between "lining cells" and "phagocytic cells" appears to have lost much of its interest under the electron microscope. Most authors have confirmed the existence of "active endothelial cells" which exhibit in their perikarya fine structures suggesting phagocytic activities (RUTTNER and VOGEL 1957, HASHI-MOTO et al 1958, YAMAGISHI 1959, MATSUO 1959, TANIKAWA at al.…”

Section: Discussionmentioning

confidence: 99%

“…RUTTNER andVOGEL (1957) andYAMAGISHI (1959) thought that the overlapped cytoplasmic lamellae might be cytoplasmic extensions either of one and the same endothelial cell or of the adjoining ones. In his review on the hepatic sinusoid ultrastructure ATERMAN (1963) has classified the endothelial lining of the hepatic sinusoid into the following four types: 1) a single sheet, 2) the overlapping cells, 3) the laminated appearance of two or more layers and 4) the appearance of a veritable labyrinth. This classification was done, however, regardless of the origin of the overlapped or laminated cytoplasmic sheets.…”

Section: Discussionmentioning

confidence: 99%