The Lipocytes in Normal Human Liver

Abstract

A quantitative analysis of lipocytes (fat-storing cells, Ito cells) has been conducted on needle liver biopsies of 8 subjects without hepatic impairment. The mean volume density of lipocytes was 1.88 ± 0.25% of parenchymal volume, and the number of lipocytes per 1,000 hepatocytes (Ito cell index) was 63.45 ± 19.18. A study of the zonal distribution showed that the values were significantly higher in the centrolobular than in the periportal areas. No correlation was evident between the volume density or the number of lipocytes and the volume density of parenchymal steatosis. The high coefficients of variation resulting from the present study are evidence that quantitative data are necessary to evaluate volumetrical or numerical variations of lipocytes.

Multivesicular stellate cells in primary biliary cirrhosis

“…The 100-hepatocyte unit used was the standard of the stellate cell index. 5,12 Stellate cells were equally well found in all three zones of acini.…”

“…Stellate cells were defined as multivesicular when more than 10 lipid vesicles were stored as in the Patients and Methods section and described by others. 5,12 † Means { SD. The 100-hepatocyte unit used was the standard of the stellate cell index.…”

“…1 Multi-1 oil immersion lens). The standard unit for comparison adopted vesicular stellate cells were described by Bronfenmajer et al 2 was that of number of fat-storing stellate cells per randomly selected in patients with alcoholic hepatitis, chronic pancreatitis, and unit of 100 hepatocytes or stellate cell index as described by Giamextrahepatic biliary obstruction, and by Wake 3,4 and by oth-pieri et al 12 At least three units (300 hepatocytes) were examined in each case. Size and electron density of lipid vesicles were measured ers 5-8 as a hepatic response to hypervitaminosis A.…”

“…9,10 However, multinormal range. 5,12 Giant or multivesicular stellate cells were defined vesicular stellate cells in PBC have not previously been rethen as stellate cells with more than 10 lipid vesicles. Statistical ported.…”

Cytoskeleton of liver perisinusoidal cells (lipocytes) in normal and pathological conditions

“…Some authors have noted a greater number in pericentral than in periportal or intralobular regions [Giampieri et al, 1981;Jezequel et al, 19841, while others have described a more uniform distribution [Sztark et al, 1986;Geerts et al, 19901. In human liver, lipocytes are present in a ratio of 3.6 to 6 cells per 100 hepatocytes [Bronfenmajer et al, 1966;Giampieri et al, 1981;Jezequel et al, 19841. They are located in the perisinusoidal space (subendothelial space of Disse).…”