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long-term residents of hospitals or residential care facilities. The sub-sample used in this analysis consisted of 38 151 respondents (52.4% male) between the ages of 20 and 64 y, excluding pregnant women. Health Utilities Index-Mark III (HUI3) scores were used to de®ne normal weight (body mass index (BMI) 19 ± 24.9 kgam 2 ), overweight (BMI 25 ± 29.9 kgam 2 ), obese (BMI 30 ± 34.9 kgam 2 ), and morbidly obese (BMI ! 35 kgam 2 ) individuals. HUI3 scores were age-and gender-standardized. RESULTS: The overall prevalence of obesity (BMI ! 30 kgam 2 ) in this Canadian population was 13.3%. The average difference in HUI3 scores between normal weight and morbidly obese respondents was 0.04 (P`0.001). Statistically signi®cant (P`0.05) differences across BMI categories were found in each of the eight component attributes of the HUI3. The attributes with the most substantial difference between normal and obese patients were cognition, mobility and pain. All demonstrated a ! 2-fold increase in the proportion of individuals in poorer classi®cations of health when normal weight respondents were compared with the morbidly obese. The magnitude of the decrement in utility ratings associated with obesity was comparable with other chronic non-cardiovascular conditions such as migraine or colitis. CONCLUSION:The results indicate that changes in self-rated health status appear to be due to signi®cant changes across several relevant domain attributes. Obesity has a signi®cant impact on both quality of life and health.

These data demonstrate the clinically relevant efficacy and short-term safety of oral pimecrolimus in adults with moderate to severe AD. Longer-term studies in larger cohorts are now required.

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little or no steatosis in 24 of 26 (92%) PBC patients. Multive-were from biopsies from the liver pathology reference files of The sicular stellate cells were not seen in female patients with Toronto Hospital. 11 Of the 26 patients with PBC, 16 had been renormal liver histology. These results suggest that there is an corded as having duct lesions and fibrosis without cirrhosis and 10 alteration in hepatic lipid storage that involves stellate cells had cirrhosis. 11 Tissue for TEM examination had been fixed in in PBC that could be an early manifestation of this disease. universal fixative (2% glutaraldehyde and 4% formaldehyde) and processed in a standard way. Numbers of stellate cells were counted

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