The stability and irritability study of the chitosan–Aloe vera spray gel as wound healing

Abstract

Objectives Chitosan is a natural polysaccharide widely used in various clinical applications including regeneration of skin tissue. Aloe vera has properties in healing burns on the skin, anti-inflammatory effect, and leaves a protective layer on the skin after drying so it provides protection to the wound. The spray gel of chitosan–A. vera was developed as a wound healing that has combined of effect of both component and easy to use. The purpose of this study was to determine the physical stability and irritability of chitosan–A. vera spray gel. Methods The spray gel stability test was conducted using thermal cycling and centrifugation methods. The organoleptic, viscosity, and pH of the spray were evaluated. The irritation test was performed by Draize Rabbit Test method. Results Chitosan (0.5%)–A. vera (1%) spray gel characteristics has a weak yellow color, clear, and a strong A. vera odor. The pH of the spray gel was 4.88 ± 0.01; and the viscosity was 36.50 ± 0.23 cps. The result from the chitosan (0.5%)–A. vera (1%) spray gel stability test using thermal cycling method showed a decrease of viscosity, but remained stable when evaluated using centrifugation method. There was no difference in the pH and organoleptic observation from both tests. Based on the scoring and analysis of the reaction in rabbit skin, the Primary Irritation Index (PII) obtained was 0.56. Conclusions The spray gel of chitosan (0.5%)–A. vera (1%) was stable and according to response category from the acute dermal irritation test, it can be concluded that chitosan (0.5%)–A. vera (1%) spray gel had a slightly irritating effect.

Active Ingredients and Natural Raw Materials Used in Foot Care in Diabetic Patients—A Literature Review

“…This effect has also been confirmed in clinical research [48]. The latest research focuses on combining aloe vera with other active ingredients (such as chitosan or extracts from algae) or developing modern formulations for topical use [49].…”

One-Pot and Green Preparation of Phyllanthus emblica Extract/Silver Nanoparticles/Polyvinylpyrrolidone Spray-On Dressing

“…Such problems can be handled by inventing a quick gel-forming spray that can be put directly on the wound without coming into contact with hands or cotton swabs, lowering the risk of infection or contaminants. Typically, these sprays generate thin, adhesive coatings, eliminating the risk of further trauma while dressing or re-dressing the wound [ 4 ]. Intimate engagement with the injured area, simple and fast treatment to vast and uneven wounds, minimal discomforts during treatment, many uses with a portable container, and ultimately improved patient compliance are all advantages of this approach [ 5 ].…”

“…In comparison to patches, a thin film created from the spray is effortless to wash off using just water [ 7 ] and can improve patient comfort while moving [ 8 , 9 ]. Due to their ease of use and benefits, spray-on dressings are becoming progressively popular [ 2 , 3 , 4 , 5 , 6 , 7 , 10 , 11 , 12 , 13 ].…”