The Spread of RS-virus Infection and other ARVI not Influenza Etiology in Children and Adults in the Regions of Russia from 2014 to 2016

Карпова, Л. С.; Smorodintseva, Elizaveta; Сысоева, Т. И.; Столярова, Т. П.; Поповцева, Н. М.; Столяров, К. А.; Danilenko, Daria; Цыбалова, Л. М.

doi:10.31631/2073-3046-2018-17-2-16-26

Cited by 5 publications

(3 citation statements)

References 7 publications

(1 reference statement)

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“…Given the high prevalence of RSV infection in Russia [ 3 , 49 ], there is a paramount need to create effective non-toxic drugs with specific anti-RSV activity, as well as sensitive diagnostic tests.…”

Section: Discussionmentioning

confidence: 99%

Characterization of a Panel of Monoclonal Antibodies Targeting the F-Protein of the Respiratory Syncytial Virus (RSV) for the Typing of Contemporary Circulating Strains

Krivitskaya,

Petrova,

Sorokin

et al. 2023

TropicalMed

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Respiratory syncytial virus (RSV) is the most common cause of upper and lower respiratory tract infections in infants and young children. Virus-specific monoclonal antibodies (mAbs) can be used for diagnosis, prophylaxis, and research of RSV pathogenesis. A panel of 16 anti-RSV mAbs was obtained from mice immunized by RSV strain Long. Half of them had virus-neutralizing activity. According to Western blot all of these mAbs effectively bound native oligomeric (homodimeric and homotrimeric) forms of the RSV fusion (F) protein. Only five of the mAbs interacted with the monomeric form, and only one of these possessed neutralizing activity. None of these mAbs, nor the commercial humanized neutralizing mAb palivizumab, reacted with the denaturated F protein. Thus, interaction of all these mAbs with F protein had clear conformational dependence. Competitive ELISA and neutralization assays allowed the identification of nine antigenic target sites for the interaction of mAb with the F protein. Five partially overlapping sites may represent a complex spatial structure of one antigenic determinant, including one neutralizing and four non-neutralizing epitopes. Four sites (three neutralizing and one non-neutralizing) were found to be distinct. As a result of virus cultivation RSV–A, strain Long, in the presence of a large amount of one of the neutralizing mAbs, an escape mutant with a substitution, N240S, in the F protein, was obtained. Thus, it was shown for the first time that position 240 is critical for the protective effect of an anti-RSV antibody. To assess the ability of these mAbs to interact with modern RSV strains circulating in St. Petersburg (Russia) between 2014 and 2022, 73 RSV-A and 22 RSV-B isolates were analyzed. Six mAbs were directed to conserved epitopes of the F protein as they interacted most efficiently with both RSV subtypes in a fixed cell-ELISA and could be used for diagnostic assays detecting RSV.

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Section: Discussionmentioning

confidence: 99%

Characterization of a Panel of Monoclonal Antibodies Targeting the F-Protein of the Respiratory Syncytial Virus (RSV) for the Typing of Contemporary Circulating Strains

Krivitskaya,

Petrova,

Sorokin

et al. 2023

TropicalMed

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“…Введение В предыдущем исследовании проведена оценка распространенности респираторно-синцитиальной (РС) инфекции и других ОРВИ не гриппозной этиологии в разных возрастных группах населения городов, расположенных в различных регионах и климатогеографических зонах России [1].…”

Section: Original Articlesunclassified

The Impact of Influenza of Different Etiologies on other ARVI in Children and Adults in 2014 to 2016

Карпова¹,

Волик²,

Smorodintseva³

et al. 2019

Epidemiology and Vaccine Prevention

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Влияние гриппа различной этиологии на другие ОРВИ у детей и взрослых в 2014-2016 годах Резюме Для оценки связи между заболеваемостью гриппом и РС-, корона-, метапневмо-, адено-рино-, бока-вирусными инфекциями и парагриппом проведен корреляционный анализ случаев гриппа и каждой из вышеперечисленных инфекций в возрастных группах населения 24 городов РФ. Возрастная структура заболевших имела значительные отличия. Среди взрослого населения чаще выявляли грипп, больше А(H1N1)pdm09 (61,4%), ОРВИ не гриппозной этиологии-среди детей 0-2 лет, особенно бокавирусную и РС-вирусную (72,5-62,8%) инфекции. Доля взрослых была больше, чем детей 3-6 лет, при корона-, рино-и парагриппозной инфекциях. Подтверждена выраженная зимне-весенняя сезонность гриппа. РС-, корона-и метапневмо-вирусные инфекции имели сдвиг на весенний период, а аденовирусная, парагрипп, бока-и рино-вирусные инфекции-на осенний. Показана прямая положительная корреляционная связь заболеваемости гриппом населения в целом с РС-, корона-, метапневмо-, адено-вирусными инфекциями и парагриппом, но не было значимой корреляции с рино-и бокавирусными инфекциями. Корреляционные связи у взрослого населения с гриппом были больше (сильная-при РС-инфекции) и выявлялись раньше, чем у детей. Продолжительность корреляционной связи с гриппом зависела от этиологии ОРВИ, этиологии гриппа и от возраста.

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“…Результаты лабораторных исследований возбудителей ОРВИ и гриппа позволяют утверждать, что, в отличие от РФ в целом, для г. Москвы ведущее место занимают вирусы парагриппа, аденовирусы и РС-вирусы, в то время как, по данным литературы, на территории РФ среди ОРВИ негриппозной этиологии преобладают риновирусы (13,5%), РС-вирусы (8%), парагрипп (4,4%) и аденовирусная инфекция (4,1%) [15,16]. В Москве в эпидсезоне 2014-2015 гг.…”

Section: смертность от орви и гриппаunclassified

Epidemiological characteristics of acute respiratory viral infection and influenza in Russian Federation and Moscow

Салтыкова

Жигарловский

Иваненко

et al. 2019

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Аim: Give an epidemiological description of the incidence of acute respiratory viral infection and influenza in the Russian Federation and Moscow.Materials and methods: The form of the federal state statistical observation № 2 “Information on infectious and parasitic diseases” for 2007–2017. When analyzing the etiological structure of the agents of ARVI and influenza in Moscow, protocols were used for weekly laboratory tests of agents of ARVI and influenza conducted by the Center for Hygiene and Epidemiology in Moscow.Results: The epidemic process of ARVI in Russia is characterized by a stabilization of morbidity with an average annual growth rate of 0,4%, and Moscow has a moderate tendency to reduce morbidity with an average annual rate of decline of 2,3%. The highest incidence of ARVI is observed among children under 1 year, 1–2 years and 3–6 years. The greatest proportion in the structure of the incidence of ARVI is children under 17 years. Both for Russia and for Moscow, there is a pronounced tendency to reduce the incidence of influenza. In contrast to ARVI, the largest proportion of people with influenza in Russia and in Moscow are adults, but the highest incidence rates are registered among the children. The epidemic rise of the incidence of ARVI and influenza in Moscow starts 10–12 weeks earlier than in the Russia as a whole.Conclusion: For the epidemic of ARVI in Moscow and in Russia it is typical to involve children under 1 year, 1–2 years and 3–6 years. In Moscow in 2016 and 2017 there is a significant increase in the incidence of influenza among children under 1 year and 1–2 years. In contrast to the Russian Federation for Moscow among the causative agents of non-influenza etiology, dominated parainfluenza viruses (1–3 types) and adenoviruses.

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The Spread of RS-virus Infection and other ARVI not Influenza Etiology in Children and Adults in the Regions of Russia from 2014 to 2016

Cited by 5 publications

References 7 publications

Characterization of a Panel of Monoclonal Antibodies Targeting the F-Protein of the Respiratory Syncytial Virus (RSV) for the Typing of Contemporary Circulating Strains

Characterization of a Panel of Monoclonal Antibodies Targeting the F-Protein of the Respiratory Syncytial Virus (RSV) for the Typing of Contemporary Circulating Strains

The Impact of Influenza of Different Etiologies on other ARVI in Children and Adults in 2014 to 2016

Epidemiological characteristics of acute respiratory viral infection and influenza in Russian Federation and Moscow

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