The spectrum of meconium disease in infancy

Olsen, Margaret M.; Luck, Susan R.; Lloyd-Still, John D.; Raffensperger, John G.

doi:10.1016/s0022-3468(82)80093-6

Cited by 56 publications

(17 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One series of 25 patients with meconium plug syndrome found an impressive 24% who were found to have the cystic fibrosis mutation [7]. Recently, an even higher incidence (43%) appeared in the literature [4].We found no association with cystic fibrosis and meconium plug syndrome in our series. This contrasting result may relate to the definition of meconium plug syndrome.…”

Section: Discussioncontrasting

confidence: 47%

“…This implies that patients may have been included with ileal plugs. In the other report, meconium plug syndrome is in fact defined as meconium located in the colon but does not speak of whether the population is meconium exclusively in the colon [4]. That we had no patients with cystic fibrosis supports a theory that a meconium plug obstruction in the colon is a different disease entity than one located in the distal small bowel as previously reported [2].…”

Section: Discussionmentioning

confidence: 45%

“…In our series, patients with typical meconium ileus appearing as ileal obstruction with proximal small bowel dilatation and microcolon were not included as meconium plug syndrome patients. In the past, cystic fibrosis, the usual cause of meconium ileus, has been reported to be associated with meconium plug syndrome [4,7]. One series of 25 patients with meconium plug syndrome found an impressive 24% who were found to have the cystic fibrosis mutation [7].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Current significance of meconium plug syndrome

Keckler

Peter

Spilde

et al. 2008

Journal of Pediatric Surgery

View full text Add to dashboard Cite

Background-The significance of meconium plug syndrome is dependent on the underlying diagnosis. The incidence of pathologic finding, particularly Hirschsprung's disease, contributing to the presence of these plugs, has been debated. However, there are little recent data in the literature. Therefore, we reviewed our experience with meconium plugs as a cause of abdominal distension to evaluate the associated conditions and incidence of Hirschsprung's disease.

show abstract

Section: Discussioncontrasting

confidence: 47%

Section: Discussionmentioning

confidence: 45%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Current significance of meconium plug syndrome

Keckler

Peter

Spilde

et al. 2008

Journal of Pediatric Surgery

View full text Add to dashboard Cite

show abstract

“…In addition, in several of the reports an association with prematurity, low birth weight, and respiratory distress syndrome has been noted (3, 5 , 8). The pathogenesis of this ill-defined entity is obscure, but there may be some overlap with the transient functional ileus seen in premature infants with respiratory distress (6,8,13).…”

Section: Possible Pathophysiological Explanations For Postmortemfindimentioning

confidence: 99%

“…These pathological findings have been described chiefly in infants dying from the complications of meconium ileus. The specificity of these changes has not been seriously questioned although there are sporadic clinical reports of meconium ileus occumng in the absence of CF (2)(3)(4)(5)(6)(7)(8)(9). In none of these case reports is there an adequate description of the pathology of the bowel or pancreas.…”

mentioning

confidence: 99%

Diagnosis of Cystic Fibrosis in Premature Infants

King

Mueller

Heeley³

et al. 1986

Pediatr Res

View full text Add to dashboard Cite

ABSTRACT. Meconium ileus and pancreatic changes, asRESULTS described in cystic fibrosis, were found, at autopsy, in a series of six infants who received prolonged neonatal intensive care for prematurity. Cystic fibrosis had not been suspected clinically. These pathological findings are so frequent in sick premature infants, amounting to 12% of all neonatal autopsies conducted over a period of 2 yr in our unit, that we question their specificity for cystic fibrosis and suggest they may be a manifestation of disordered physiology in the severely ill neonate. The diagnosis of CF in the neonatal period in the absence of a sweat test result is based on the post mortem findings of meconium ileus and pancreatic changes (1). These pathological findings have been described chiefly in infants dying from the complications of meconium ileus. The specificity of these changes has not been seriously questioned although there are sporadic clinical reports of meconium ileus occumng in the absence of CF (2-9). In none of these case reports is there an adequate description of the pathology of the bowel or pancreas.A series of six premature infants is reported, born over a 2-yr period, in whom meconium ileus and/or pancreatic changes were found at postmortem. None of these infants had any other clinical features suggesting meconium ileus attributable to CF. In view of the frequency with which a previously unsuspected diagnosis of CF was made at postmortem over the 2-yr period and the similarity of the clinical course in these infants, the specificity of the pathological changes for establishing the diagnosis of CF in the neonate is questioned. This diagnostic dilemma has obvious implications for recurrence risk counselling.In addition, IRT estimations were camed out retrospectively on serum samples from these infants and the results are discussed.

show abstract