The Specificity of Early Changes in the Skin During Carcinogenesis

Bibby, M. C.

doi:10.1111/j.1365-2133.1981.tb15324.x

Cited by 5 publications

(1 citation statement)

References 15 publications

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“…Skin carcinogenesis is a complex, multistep process ( 12 , 13 ), and the study of early alterations in the skin and of the mechanisms involved, as well as the development of novel therapeutic strategies are of interest for both scientific research and clinical practice. Moreover, the striking increase in both the number of new topical chemical entities and their biological effects creates the need to understand the intimate molecular mechanisms that underlie their in vivo effects.…”

Section: Introductionmentioning

confidence: 99%

Chemically induced skin carcinogenesis: Updates in experimental models (Review)

et al. 2016

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Skin cancer is one of the most common malignancies affecting humans worldwide, and its incidence is rapidly increasing. The study of skin carcinogenesis is of major interest for both scientific research and clinical practice and the use of in vivo systems may facilitate the investigation of early alterations in the skin and of the mechanisms involved, and may also lead to the development of novel therapeutic strategies for skin cancer. This review outlines several aspects regarding the skin toxicity testing domain in mouse models of chemically induced skin carcinogenesis. There are important strain differences in view of the histological type, development and clinical evolution of the skin tumor, differences reported decades ago and confirmed by our hands-on experience. Using mouse models in preclinical testing is important due to the fact that, at the molecular level, common mechanisms with human cutaneous tumorigenesis are depicted. These animal models resemble human skin cancer development, in that genetic changes caused by carcinogens and pro-inflammatory cytokines, and simultaneous inflammation sustained by pro-inflammatory cytokines and chemokines favor tumor progression. Drugs and environmental conditions can be tested using these animal models. keeping in mind the differences between human and rodent skin physiology.

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Section: Introductionmentioning

confidence: 99%

Chemically induced skin carcinogenesis: Updates in experimental models (Review)

et al. 2016

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Membrane‐bound structures at the interface between tumour and dermis in basal cell carcinoma. An ultrastructural study

Morley

Rennison

Macadam

1983

The Journal of Pathology

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During an ultrastructural study of the interface area between tumour and dermis in 23 basal cell carcinoma (BCC), membrane-bound structures were noted in the dermis adjacent to the basal lamina in 12 tumours (52 per cent), but none of the controls. Serial sectioning demonstrated cytoplasmic connections between these structures and tumour cells. Their formation and interaction with adjacent stromal cells is discussed.

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Skin and Oral Mucosa

Klein‐Szanto

1991

Handbook of Toxicologic Pathology

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The Specificity of Early Changes in the Skin During Carcinogenesis

Cited by 5 publications

References 15 publications

Chemically induced skin carcinogenesis: Updates in experimental models (Review)

Chemically induced skin carcinogenesis: Updates in experimental models (Review)

Membrane‐bound structures at the interface between tumour and dermis in basal cell carcinoma. An ultrastructural study

Skin and Oral Mucosa

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