The Source of Immunoglobulin E in the Fetus at Term

Schreyer, Peter; Avrech, Ori M.; Caspi, Eliahu; Samra, Zmira; Sompolinsky, D

doi:10.1159/000293638

Cited by 7 publications

(8 citation statements)

References 4 publications

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“…This conclusion is in accordance with previous observations of a similar signif icant correlation between maternal IgE levels and fetal IgE levels assessed with cord blood obtained by venous puncture [10]. Table 1 shows that, among our maternal population, there were 4% more pregnancies with male fetuses than with female fetuses; the number of previous deliveries, the mean age of the mothers and the gestational age at birth were practically identical for these 2 groups.…”

Section: Discussionsupporting

confidence: 92%

“…We have previously demon strated a significant positive relationship between IgE lev els in mothers-newborns, fathers-newborns, and fathersmothers [10]. We suggested that the explanation for these findings was most probably the home milieu of the family, together with genetic factors.…”

Section: Discussionmentioning

confidence: 80%

“…The techniques used for determination of IgE (radioimmunoas say PRIST) and IgD (ELISA) have recently been described [ 10]. IgA and IgM levels were determined by an ELISA technique using specific enzyme-labeled antibodies.…”

Section: Methodsmentioning

confidence: 99%

“…The role of this immu noglobulin is apparently protection against animal para sites, although a high premium of host tissue damage is paid for this benefit. It is usually accepted that the placen tal barrier is not permeable to IgE [7,8], but a few authors have tried to assess the degree of impermeability of this barrier for other non-IgG immunoglobulins [2,9,10],…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of the Placental Barrier for Immunoglobulins: Correlations between Maternal, Paternal and Fetal Immunoglobulin Levels

Avrech¹,

Samra

Lazarovich

et al. 1994

Int Arch Allergy Immunol

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The relationship of immunoglobulin levels in fetal and parental blood for those classes showing a high degree of placental impermeability was investigated in 430 mothers, their newborn infants (cord blood) and their husbands. Levels of IgA, IgD and IgM in maternal serum were unrelated to the sex of the offspring. IgE levels were significantly higher in mothers of male infants than in mothers of female infants (53 versus 40 IU/ml, p < 0.02). Significant correlations between maternal-fetal (r = 0.37; p < 0.01), paternal-fetal (r = 0.12; p < 0.02) and maternal-paternal IgE levels were found (r = 0.17; p < 0.02). For the levels of other immunoglobulins studied, the maternal-fetal correlations were not significant. The results support the effectiveness of the placental barrier for IgA, IgD, IgE and IgM. The significant correlation between IgE levels in mothers-newborns, fathers-newborns and mothers-fathers may be explained by the influence of the home milieu on the entire family, including the fetus.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 80%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Efficacy of the Placental Barrier for Immunoglobulins: Correlations between Maternal, Paternal and Fetal Immunoglobulin Levels

Avrech¹,

Samra

Lazarovich

et al. 1994

Int Arch Allergy Immunol

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“…Although admixture with maternal blood may occur [18], it is unlikely to affect the CB-IgE levels. In support of this view, the concentrations of IgE in arterial and venous cord blood were shown to be almost completely identical [19]. In our study, no sample showed IgA levels above 60 mg/1.…”

Section: Discussionsupporting

confidence: 85%

Cord Blood IgE against Milk and Egg Antigens

Furuhashi¹,

Sugiura

Katsumata³

et al. 1997

Neonatology

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The aim of the present study was to reevaluate the prenatal production of specific IgE for eggs and milk and, in those cases, to determine whether there is a relation to the amount of maternal egg and milk intake. Total and specific IgEs from 160 cord blood samples were determined by immunoassays using a paramagnetic particle solid phase and an enzyme-mediated chemiluminescent reaction for signal detection. The levels of cord blood IgE for total, egg, and milk were 0.63 ± (SD) 1.10 IU/ml, 0.020 ± 0.055, and 0.036 ± 0.053 IU/ml, respectively. IgE levels specific to egg and milk over 0.03 IU/ ml were observed in 33 and 70 out of 160 cases, respectively. To address whether the maternal intake of eggs and milk affects the level of cord blood IgEs, all mothers except 9 were interviewed, and the amount of eggs and milk taken during pregnancy was recorded. No correlation was seen between egg and milk intakes and cord blood IgE levels. Our data demonstrate a high incidence of the prenatal production of specific IgE for eggs and milk which is independent of maternal egg and milk intakes.

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Relationships among prenatal aeroallergen exposure and maternal and cord blood IgE: Project ACCESS

Peters¹,

Suglia²,

Platts-Mills³

et al. 2009

Journal of Allergy and Clinical Immunology

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Background While some evidence suggests that antigen sensitization may begin prenatally, the influence of maternal allergen exposure during pregnancy has not been fully elucidated. Objectives We examined the relationship between prenatal maternal aeroallergen exposure and cord blood total immunoglobulin E (IgE) and the potential mediating/indirect effect of maternal immune response. Methods This study was performed in 301 mother-infant pairs enrolled in the Asthma Coalition on Community, Environment, and Social Stress (ACCESS) project, a study examining the effects of prenatal and early life social and physical environmental exposures on urban asthma risk. Dust samples collected prenatally from mothers’ bedrooms were analyzed for cockroach and dust mite allergens. Cord blood was analyzed for total IgE and maternal serum collected during pregnancy for total and specific IgE. We assessed the relationship between prenatal exposure and cord blood total IgE and the potential mediation effect adjusting for maternal age, race, education, smoking status and dust collection season; and child’s gender and season of birth. Results In multivariate models, elevated prenatal dust mite levels (> 0.2 µg/g) increased cord blood IgE concentrations by 29% (p=0.08) and continuous dust mite concentration was associated with a significant non-linear increase in cord blood IgE (p=0.02). Elevated prenatal exposure to cockroach allergen (> 2 U/g) was not associated with cord blood IgE, but showed a significant indirect relationship through maternal total IgE (β=0.23; 95% CI: 0.08, 0.41). Conclusions These results demonstrate that maternal prenatal exposure to household allergens may impact cord blood IgE albeit the underlying mechanism may be allergen-specific. Clinical Implications Maternal prenatal inhalant allergen exposure may precipitate infant immune response although the pathway of the effect may differ by allergen. Capsule Summary Prenatal exposure to dust mite was associated with increased cord blood total IgE whereas the relationship between prenatal cockroach exposure and total cord blood IgE was only observed through the indirect effect of maternal allergic response.

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The Source of Immunoglobulin E in the Fetus at Term

Cited by 7 publications

References 4 publications

Efficacy of the Placental Barrier for Immunoglobulins: Correlations between Maternal, Paternal and Fetal Immunoglobulin Levels

Efficacy of the Placental Barrier for Immunoglobulins: Correlations between Maternal, Paternal and Fetal Immunoglobulin Levels

Cord Blood IgE against Milk and Egg Antigens

Relationships among prenatal aeroallergen exposure and maternal and cord blood IgE: Project ACCESS

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