The solubility properties of granulopoiesis inhibiting factor

Paukovits, Walter R.; Paukovits, Johanna B.

doi:10.1007/bf01945825

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) Crude Fractionation1

Chemical Nature Of Granulocytic Chalone1

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1977

1999

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Cited by 6 publications

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“…GIF appears to be soluble in polar organic solvents 1 24 1, which lead to the development of a procedure! 11 !…”

Section: ) Crude Fractionationmentioning

confidence: 99%

Methods for the Preparation of Purified Granulopoiesis-Inhibiting Factor (Chalone)

Paukovits¹,

Lærum²,

Paukovits³

et al. 1983

Hoppe-Seyler´s Zeitschrift für physiologische Chemie

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“…GIF appears to be soluble in polar organic solvents 1 24 1, which lead to the development of a procedure! 11 !…”

Section: ) Crude Fractionationmentioning

confidence: 99%

Methods for the Preparation of Purified Granulopoiesis-Inhibiting Factor (Chalone)

Paukovits¹,

Lærum²,

Paukovits³

et al. 1983

Hoppe-Seyler´s Zeitschrift für physiologische Chemie

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“…V/V). It is not soluble in pure chloroform, and it cannot be extracted from aqueous solutions into 1-butanol [28]. This seems to indicate a rather polar molecule.…”

Section: Chemical Nature Of Granulocytic Chalonementioning

confidence: 99%

The Granulocytic Chalone – A Specific Inhibitor of Granulopoiesis: Molecular Weight and Chemical Nature

Paukovits¹,

Hinterberger²,

Paukovits³

1977

Oncology

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Chalones specifically inhibit cell proliferation not only in their respective normal cell system, but also in the malignant descendants of these cells. Consequently, a number of hypotheses have been put forward as to how chalones could be used in cancer treatment or related areas. As chalones are not cytotoxic themselves, but merely inhibit proliferation, the regression of tumors which has been observed in some cases must have been caused by other mechanisms, not directly related to the increased chalone level. Some of the potential advantages and drawbacks of this direct approach will be discussed. Some models in which chalones serve as adjuncts to other forms of therapy will be discussed. The experimental testing of these procedures and hypotheses is hampered severely by the unavailability of satisfactory chalone preparations. A possible approach to overcome this by using synthetic granulocytic (and possibly other) chalone(s) is discussed in detail.

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“…Additional requirement for mature cells in different pathological states leads to excessive strain of the hemopoietic system, in particular, massive recruitment of hemopoietic precursors necessary tbr repopulation of the low-differentiated cell niches [4,67,90]. These situations regularly arise in all complex organisms and could completely deplete the stem cell pool [90,113,117], if they responded to each stimulation. These considerations led to a conclusion on the existence of local mechanisms responsible for quantitative regulation of hemopoiesis at the level of committed and partially differentiated precursors and limiting the reaction of polypotent stem cells to indirect nervous and humoral stimuli.…”

mentioning

confidence: 99%