Dynamic theory of hemopoiesis regulation

Self Cite

We studied the mechanisms of erythropoiesis regulation in a conflict situation and during paradoxical sleep deprivation. Plastic reconstruction of the erythroid hemopoietic stem during experimental neuroses is regulated by a complex multicomponent and multilevel system. This system consists of central adrenergic structures, sympathetic part of the autonomic nervous system, and α-and β-adrenoceptors on erythroid precursors and cells of the hemopoietic microenvironment. Erythroid cells receive instructive information from the central nervous system via adrenoceptors on cells of the hemopoiesis-inducing microenvironment and erythroid precursors. Hyperplasia (conflict situation) and suppression of erythropoiesis (paradoxical sleep deprivation) are associated with specificity of central adrenergic regulatory mechanisms.

Section: Methodsmentioning

confidence: 99%

Mechanisms of Regulation of Erythropoiesis during Experimental Neuroses

Скурихин

Дыгай²,

Provalova³

et al. 2005

Self Cite

“…Hemopoietic cells depend on not only hemopoietic growth factors and inhibitors, but also catecholamines (epinephrine and norepinephrine) produced by neurons and cells [1,2,7]. Dopamine was also found in short-and long-living bone marrow cultures [11,12], which suggests that this amine can produce a regulatory effect on multipotent stem cells and more mature precursors.…”

Section: Resultsmentioning

confidence: 99%

“…The concept on role of local regulation of reproduction of the cell composition of the hemopoietic tissue and its functional activity under normal and pathological conditions (e.g. myelosuppression) was developed [1,7]. At the same time, activation of dopaminergic system leads to immunostimulation [4,5,9] accompanied by accumulation of CD4 + T cells in the bone marrow [6], increase in the count of antibody-producing and rosette-forming cells in the spleen of experimental animals, abolition of the stressinduced suppression of the immune reaction [10], and enhancement of proliferative response of T cells to mitogens [13].…”

mentioning

confidence: 99%

Dopaminergic regulation of erythropoiesis in modeled myelosuppressions induced by cyclophosphamide and 5-fluorouracil

Minakova¹,

Скурихин²,

Першина³

2007

We studied the role of the dopaminergic system in the regulation of erythropoiesis in cytostatic myelosuppressions. During cyclophosphamide and 5-fluorouracil treatment, the state of erythropoiesis precursors, functional activity of cell elements of hemopoiesis-inducing mircroenvironment (secretion of erytropoietic activity, formation of hemopoietic islets) are controlled by dopaminergic structures of the brain. The regulatory effect of CNS is mediated via dopamine receptors on precursors and microenvironmental cells and via modulation of activity of the erythropoietin system. Specific dopaminergic control of hemopoiesis-inducing microenvironment and erythroid precursors is determined by peculiarities of the suppressive effects of the alkylating agent and antimetabolite on the blood system.

“…It can be hypothesized that serotonin can not only stimulate, but also inhibit processes in various compartments of the system of local erythron regulation. The differences between the models in the shifts of the studied parameters in response to cyproheptadine treatment can be explained by specific suppressive effects of the alkylating agent and antimetabolite on bone marrow cells and regulatory systems [1,3].…”

Section: Resultsmentioning

confidence: 99%

“…Under extreme conditions (immobilization stress, blood loss, cytostatic and neurotizing exposures, hypoxia, etc. ), the α-and β-adrenergic receptor mechanisms regulate activity of committed hemopoietic precursors and cells of the hemopoiesis-inducing microenvironment (HIM) [1][2][3]. The role of central regulatory elements is played by the sympathetic nervous system [2,3] and adrenergic brain structures [2].…”

mentioning

confidence: 99%

Role of serotoninergic system in regulation of erythropoiesis during cytostatic myelosuppressions

Minakova¹,

Скурихин²,

Першина³

et al. 2007

We studied the role of serotoninergic system in the regulation of erythropoiesis after treatment with cyclophosphamide and 5-fluorouracil. The state of erythropoiesis precursors and functional activity of cell elements of hemopoiesis-inducing mircroenvironment (secretion of hemopoietic activity, formation of hemopoietic islets) are controlled by serotoninergic structures of the brain. The regulatory effect of CNS is mediated via serotonin receptors on precursors and microenvironmental cells and via modulation of activity of the erythropoietin system. Specific shifts in the erythron are determined by peculiarities in the interaction between distant and local controlling structures and suppressive effect of cyclophosphamide and 5-fluorouracil on hemopoietic cells and regulatory systems.