The Significant Association of the dupA and cagA genes of Helicobacter pylori with Peptic Ulcer

Abstract

Journal homepage: www.zums.ac.ir/jhehp Background: Helicobacter pylori play a significant etiological role in various digestive diseases. Peptic ulcer is caused by H. pylori, which destroys the duodenum mucus and is often observed in the individuals consuming tobacco, spicy and heavy meals, alcohol, coffee, and tranquilizers. Several studies have indicated that duodenal ulcer promoting genes dupA and cagA are involved in H. pylori etiology. The present study aimed to evaluate the correlation between these genes and peptic ulcer. Methods: In this study, 500 stomach biopsy samples were assessed based on the rapid urease test and polymerase chain reaction (PCR) for H. pylori infection, followed by histological and microscopic examinations. Results: The dupA and cagA genes were subjected to PCR. Although dupA showed no significant correlation with peptic ulcer, the cagA genotype had a significant association with peptic ulcer (P < 0.05). Similar to the dupA gene, blood group was not observed to be correlated with H. pylori infection. Conclusion: According to the results, there are significant correlations between tobacco use (P < 0.05), tranquilizer use (P < 0.05), and meteorism (P < 0.05) with peptic ulcer. In addition, the expression of the cagA and dupA genes was investigated in patients with nonulcer dyspepsia and peptic ulcer.

Helicobacter Pylori Different Virulence Genes and the Risk of Gastric Cancer in Iranian Patients

“…Similarly, the subsequent analysis showed that infection by cagA-positive H. pylori isolates can increase the risk of GC [35]. Gohardani et al showed that the expression of cagA was higher in Iranian patients with peptic ulcers compared to those with non-ulcer dyspepsia [41]. However, in studies conducted in Korea and Japan, there was no signi cant association between the cagA gene and the severity of gastroduodenal diseases [42,43].…”