A systematic review and meta-analysis of outcomes of infection with Helicobacter pylori dupA+ strains in Iranian patients

Ali‐Hassanzadeh

2020

BMC Gastroenterol

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Background: Helicobacter pylori is accounted as the most etiologic agent for digestive disorders, in particular, the most important of them i.e. peptic ulcer and gastric cancer. In the recent years, association of vacA genotypes and gastrointestinal disorders has attracted a lot of attention. In present study, we assessed the correlation between vacA genotypes (s1, s2, m1, m2, s1m1, s1m2, s2m1 and s2m2) and development to peptic ulcer in Iranian population. Methods: In our study, first, 24 original articles containing of information of 3328 patients were evaluated. Statistical analysis was done by Comprehensive Meta-Analysis version 2.0 software (Biostat, Englewood, NJ, USA). In this regards, we used from fixed-effects model for analysis of data with low heterogeneity, while for analysis of data with high heterogeneity (I 2 statistic index > 25%, Cochrane Q statistic p value < 0.05), random-effects model was used.

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association of Helicobacter pylori vacA genotypes and peptic ulcer in Iranian population: a systematic review and meta-analysis

Ali‐Hassanzadeh

2020

BMC Gastroenterol

Self Cite

“…The bacterium is accounted as etiologic agent in disorders such chronic gastritis, peptic ulcer, as well as gastric cancer. However, H. pylori-related extra-gastrointestinal diseases have attracted a lot of attention, in which the relevance of H. pylori infection and CVD is well-known (25,26). In addition to the several evidence regarding with isolation of H. pylori from atherosclerotic plaques, there are various documents about the effect of infection by this bacterium on some complications including insulin resistance, dyslipidemia, hypertension, and alteration in metabolism which describe the potential role of infection with this bacterium in increasing of ischemic stroke (27,28).…”

Section: Discussionmentioning

confidence: 99%

Potential Association Between Bacterial Infections and Ischemic Stroke Based on Fifty Case-Control Studies: A Systematic Review and Meta-Analysis

2020

Preprint

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Background: Stroke is considered as one of the most concerns in health services facilities worldwide, and occurs in two types, ischemic stroke and hemorrhagic stroke. However, almost the three quarters of stroke cases are ischemic stroke which occur in effect of several risk factors such as hypertension, obesity, atherosclerosis, diabetes mellitus, arteritis, and inflammatory response. In recent years, infectious diseases are considered as one of the most important risk factors of ischemic stroke. In this regard, some bacteria causing the chronic infections in particular Chlamydia pneumonia, Helicobacter pylori, Mycoplasma pneumonia, and Mycobacterium tuberculosis get more attended. Methods: In the present meta-analysis, we studied 50 case-control studies and evaluated potential relevance of these infections with creation and development of ischemic stroke. Results: We surveyed the information of 33,978 participants in several nested case-control studies and demonstrated that bacterial infections can increase the risk of ischemic stroke.Conclusions: In this meta-analysis we demonstrated a meaningful relationship between infection by three bacteria C. pneumoniae, H. pylori, and M. tuberculosis with occurrence of ischemic stroke.

“…Almost half of world population are infected to H. pylori, nevertheless, the rate of colonization in developing countries is more compared to western countries; most of population in developing countries rst time infected with this bacterium in childhood ages (14)(15). The International Agency for Research on Cancer (IARC) introduced this bacterium as the main causing enemy of gastric cancer (15)(16). Also, this bacterium is accounted for some diseases such as primary gastric non-Hodgkin's lymphoma, mucosa-associated lymphoid tissue lymphoma (MALT), gastritis, and peptic ulcer (17).…”

Section: Introductionmentioning

confidence: 99%

Association of Helicobacter pylori vacA genotypes and peptic ulcer in Iranian population: a systematic review and meta-analysis

Ali‐Hassanzadeh

2020

Preprint

Self Cite

Background Helicobacter pylori is accounted as the most etiologic agent for digestive disorders, in particular, the most important of them i.e. peptic ulcer and gastric cancer. In the recent years, association of vacA genotypes and gastrointestinal disorders has attracted a lot of attention. In present study, we assessed the correlation between vacA genotypes (s1, s2, m1, m2, s1m1, s1m2, s2m1 and s2m2) and development to peptic ulcer in Iranian population. Methods In our study, first, 23 original articles containing of information of 3328 patients were evaluated. Statistical analysis was done by Comprehensive Meta-Analysis version 2.0 software (Biostat, Englewood, NJ, USA). In this regards, we used from fixed-effects model for analysis of data with low heterogeneity, while for analysis of data with high heterogeneity (I2 statistic index > 25%, Cochrane Q statistic p value < 0.05), random-effects model was used. Results Abundance of each of s1, s2, m1, m2, s1m1, s1m2, s2m1, and s2m2 was estimated 36.24%, 28.32%, 42.90% 29.86%, 27.88%, 32.34%, 15.70%, and 25.94%, respectively. According to the results, the m1, s1, and s1m2 genotypes were among the most prevalent genotypes among the Iranian patients, whereas, s2m1 genotype had the lowest frequency. Conclusions Finally, we demonstrated that there is a significant relationship between infection of stomach with m1, s1m1, and s2m1 genotypes and development to peptic ulcer.