1977
DOI: 10.1101/sqb.1977.041.01.069
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The Significance of T-B Collaboration across Haplotype Barriers

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Cited by 32 publications
(33 citation statements)
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“…This is similar to the findings in the murine system that radiation-sensitive, Lytl-2+ T cells can mediate a potent negative allogeneic effect on the capacity of primed cells to develop a secondary in vitro antibody response to antigen (33). In contrast to the findings of others (24,35), who have noted negative, but not positive, allogeneic effects in human antigen-specific antibody production, we have consistently noted potent positive allogeneic effects independent of the presence of antigen in culture, which were only appreciated after the negative allogeneic effects were abrogated either by low-dose irradiation or elimination of OKT8+ T cells. This effect is presumably similar to that seen by the addition of mixed lymphocyte reaction supernatants to unfractionated PBMNC (35,36) or to T cell-depleted populations (36,37).…”
Section: Discussioncontrasting
confidence: 55%
“…This is similar to the findings in the murine system that radiation-sensitive, Lytl-2+ T cells can mediate a potent negative allogeneic effect on the capacity of primed cells to develop a secondary in vitro antibody response to antigen (33). In contrast to the findings of others (24,35), who have noted negative, but not positive, allogeneic effects in human antigen-specific antibody production, we have consistently noted potent positive allogeneic effects independent of the presence of antigen in culture, which were only appreciated after the negative allogeneic effects were abrogated either by low-dose irradiation or elimination of OKT8+ T cells. This effect is presumably similar to that seen by the addition of mixed lymphocyte reaction supernatants to unfractionated PBMNC (35,36) or to T cell-depleted populations (36,37).…”
Section: Discussioncontrasting
confidence: 55%
“…First, the role of histocompatibility or allogeneic differences between the T cells being analyzed and the B cells used as indicator anti-HBs synthesizing lymphocytes could not be assessed (31,32). Selected specific immune responses may be more sensitive to nonspecific allogeneic suppressor T cell activity or be less sensitive to allogeneic helper T cell activity.…”
Section: Co-culture Experimentsmentioning
confidence: 99%
“…Experiments based on the comparison between allogenic and syngenic immune responses demonstrated strong restriction in some instances (6,8,(10)(11)(12) but weak or absent restriction in others (8,(68)(69)(70)(71)(72). Thus, it is difficult to draw any conclusion on the average level of self restriction from experimental data.…”
Section: Discussionmentioning
confidence: 99%