The Significance of Glycosuria

Jackson, W. P. U.; Marine, N.; Vinik, A

doi:10.1016/s0140-6736(68)90899-4

Cited by 14 publications

(6 citation statements)

References 6 publications

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“…3 The intermittent nature of hyperglycemia has bee documented in man. 12 -15 Therefore, its occurrence i M. albicaudatus is not unexpected because diabetes me litus in this species appears to be very similar, in boi complexity and diversity, to what has been described i man. Of the 161 animals which have had multiple seru glucose determinations with only one hyperglycem value, some are expected to demonstrate repeated hype glycemia, with or without intermittent hyperglycemi and to progress into overt, clinical diabetes mellitus they are repeatedly monitored.…”

Section: Discussionmentioning

confidence: 68%

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Spontaneous Diabetes Mellitus in Mystromys Albicaudatus: Repeated Glucose Values from 620 Animals

1972

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The serum glucose values of 1,423 blood samples from 620 Mystromys albicaudatus have been determined and defined as orthoglycemic or hyperglycemic. Analyses of variance tests and regression analyses of the data revealed a significant difference between orthoglycemic and hyperglycemic serum glucose means and indicated that serum glucose is not affected by sex, inbreeding, or age in these animals. However, within classifications of orthoglycemic and hyperglycemic, weight did affect serum glucose. Therefore, while obesity did not occur during this study, obese-hyperglycemia syndromes might be expected should the animals become overweight.The data and their analyses are strongly indicative that spontaneous diabetes mellitus in M. albicaudatus, as related to hyperglycemia, is very similar to the disease in man.

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Section: Discussionmentioning

confidence: 68%

“…Each of 620 members-of the colony was bled periodically to determine his serum glucose value. The schedule was to bleed each animal when it reached 4, 6,9,12,18,24,36, and 48 mo. of age.…”

mentioning

confidence: 99%

Spontaneous Diabetes Mellitus in Mystromys Albicaudatus: Repeated Glucose Values from 620 Animals

1972

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“…Renal glycosuria is the urinary excretion of abnormal amount of glucose, while maintaining a normal glucose concentration. 6 This identity can be recognized among people with familial renal glycosuria which is a rare tubular disorder or in patients receiving drugs such as tenofovir. 7 Mutations with the renal sodium glucose cotransporter 2 (SGLT2) gene (in other words SLC5A2 gene) lead to familial renal glycosuria.…”

Section: Discussionmentioning

confidence: 99%

A Case with Renal Glycosuria

Kaynar¹,

Şehit²,

Coşar³

et al. 2018

Turkiye Klinikleri J Case Rep

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nder normal conditions, kidneys assist glucose homeostasis by synthesizing glucose via gluconeogenesis and preventing urinary glucose loss via tubulary glucose reabsorption. 1 Reabsorption of glucose which is freely filtered in the glomeruli almost completely occur in proximal tubules only. This glucose reabsorption is mostly (90%) carried out by sodium-glucose cotransporters type 2 (SGLT-2) and glucose transporters 2 (GLUT2). So in patients with normal kidney function, significant glycosuria does not generally occur until the plasma glucose concentration exceeds 180 mg/dL (10 mmol/L). 2 Glycosuria may be due to either the inability of the kidney to reabsorb filtered glucose in the proximal tubule despite normal plasma glucose concentration, or to an overflow scenario related to high plasma glucose concentrations overwhelming the capacity of the renal tubules to reabsorb glucose. The commonest cause of glycosuria is uncontrolled diabetes mellitus. Abnormally elevated levels of glucose in the blood result in high amount of filtered glucose waiting to be reabsorbed through overactive SGLT2 which execute reabsorption eventually. When glycosuria occurs with a normal plasma glucose, a primary defect of proximal tubule reabsorption (renal glycosuria) needs to be considered. 1,2 Renal glycosuria is a rare and long

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“…Another limitation is that not all persons with glycosuria have, or develop, NIDDM, as 35 ± 50% of men and 70 ± 80% of women aged 50 ± 70 y with postprandial glycosuria have NIDDM. This estimate is based on observations in a number of surveys, including the Diabetes Survey in Bedford, England in 1962 (Keen, 1964;Butter®eld et al, 1967) and studies in other ethnic groups (Jackson et al, 1968;Cheah et al, 1972;Chaisiri et al, 1997). Our predictive value is likely to be higher, because we only included persons with approximated fasting glycosuria, who are more likely to have NIDDM than those with postprandial glycosuria (Davies et al, 1993).…”

Section: Discussionmentioning

confidence: 99%

A cross-sectional study of dietary habits and urinary glucose excretion — a predictor of non-insulin-dependent diabetes mellitus

et al. 2000

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Objective: To investigate the association between consumption of certain foods and macronutrients and urinary glucose excretion, which is a predictor of non-insulin-dependent diabetes mellitus. Design: A cross-sectional study, Denmark, 1993 ± 97. Subjects: Participants in the Danish study`Diet, Cancer and Health'. After exclusion of persons with postprandial urine samples and persons with diabetes or other diseases potentially resulting in glycosuria, the study population included 14 743 men and 18 064 women aged 50 ± 64 y. We identi®ed 183 men and 43 women with glucose in their urine. Results: Consumption of poultry was negatively associated with glycosuria in both men (odds ratio, OR 0.87; 95% con®dence interval, 95% CI 0.77 ± 0.98) and women (OR 0.69; 0.48 ± 1.00). Fiber from fruit showed a weak negative association with glycosuria in both men (0.95; 0.90 ± 1.01) and women (0.89; 0.78 ± 1.02), whereas a signi®cant negative association with total ®ber (0.68; 0.51 ± 0.91) and ®ber from vegetables (0.94; 0.88 ± 0.99) was seen in men. Intake of ®sh tended to reduce the risk of glycosuria in women only (0.80; 0.63 ± 1.02), whereas ingestion of milk products increased their risk signi®cantly (1.15; 1.06 ± 1.24). Conclusion: Although statistical signi®cance and consistency in the two sexes were not achieved for all endpoints, the study indicates a protective effect of dietary products like poultry, fruit and cereals against glycosuria and suggests a promoting effect of milk. Sponsorship: The Danish National Board of Health and the Danish Cancer Society.

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The Significance of Glycosuria

Cited by 14 publications

References 6 publications

Spontaneous Diabetes Mellitus in Mystromys Albicaudatus: Repeated Glucose Values from 620 Animals

Spontaneous Diabetes Mellitus in Mystromys Albicaudatus: Repeated Glucose Values from 620 Animals

A Case with Renal Glycosuria

A cross-sectional study of dietary habits and urinary glucose excretion — a predictor of non-insulin-dependent diabetes mellitus

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