The short-term effects of electrosurgical ablation on proinflammatory mediator production by intervertebral disc cells in tissue culture

Rhyu, Kee-Won; Walsh, Andrew J.; O’Neill, Conor; Bradford, David S.; Lotz, Jeffrey C.

doi:10.1016/j.spinee.2006.07.006

Cited by 14 publications

(5 citation statements)

References 40 publications

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“…IL‐6, moreover, plays an important role in bone inflammation/pain by increasing osteoclastic activity and involves generation of neuropathic pain after peripheral nerve injury in an animal model . In the current study, increases of IL‐6 and IL‐8 were observed following surgery and peaked during postoperative hours 12–24 in wound drainage, as reported in other studies , although additional studies have demonstrated earlier postoperative peaks of IL‐6 and IL‐8 at 4–7 hours . This might be due to differences in patient populations and disease entities, surgical procedures, anesthetic methods, methods of drainage fluid collection, etc.…”

Section: Discussionsupporting

confidence: 63%

Effect on Pain Relief and Inflammatory Response Following Addition of Tenoxicam to Intravenous Patient-Controlled Morphine Analgesia: A Double-Blind, Randomized, Controlled Study in Patients Undergoing Spine Fusion Surgery

Chang¹,

Yang³

et al. 2013

Pain Med

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Section: Discussionsupporting

confidence: 63%

Effect on Pain Relief and Inflammatory Response Following Addition of Tenoxicam to Intravenous Patient-Controlled Morphine Analgesia: A Double-Blind, Randomized, Controlled Study in Patients Undergoing Spine Fusion Surgery

Chang¹,

Yang³

et al. 2013

Pain Med

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“…23,27 IL-1a is mainly membrane-bound, 8,43 but can exert activity on neighboring cells and is capable of inducing the production and release of other cytokines, particularly when acting synergistically with TNFa. 8,35 In the current study, IL-1ra, which blocks the effect of both IL-1a and IL-1b, reduced mechanical allodynia compared to vehicle treatment (Figs. 3 and 4).…”

Section: Discussionsupporting

confidence: 51%

Cytokine Antagonism Reduces Pain and Modulates Spinal Astrocytic Reactivity After Cervical Nerve Root Compression

Rothman

Winkelstein

2010

Ann Biomed Eng

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Relationships between nerve root compression, behavioral sensitivity, spinal cytokines, and glial reactivity are not fully defined for painful cervical nerve root compression. Spinal cytokines were quantified after mechanical root compression (10gf), root exposure to inflammatory chromic gut material (chr), the combination of both insults together (10gf + chr) or sham. TNFalpha and IL-1beta significantly increased at 1 h (p < 0.029). IL-1alpha was significantly increased over normal, sham and chr at 1 h following 10gf and over normal and sham after 10gf + chr (p< 0.048). By day 1, only IL-1beta after 10gf remained elevated over normal (p = 0.038). Accordingly, the soluble TNF receptor-1 (sTNFR1) and the IL-1 receptor antagonist (IL-1ra) were separately administered at early time points after each injury. With sTNFR1, behavioral sensitivity was significantly decreased for 7 days after both 10gf and 10gf + chr (p < 0.005). Treatment with IL-1ra significantly reduced sensitivity for 10gf + chr (p < 0.034) but not for 10gf. Sensitivity remained significantly elevated over sham at all time points (p < 0.044). Spinal astrocytic reactivity significantly decreased for both treatments after 10gf (p < 0.002); but, only IL-1ra following 10gf + chr significantly reduced astrocytic reactivity (p < 0.001). Early increases in spinal TNFalpha, IL-1beta, and IL-1alpha may induce pain, affect spinal astrocytic responses, and appear to have differential effects in mediating the behavioral hypersensitivity produced by different types of painful cervical radicular injuries.

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“…Another mechanism may be responsible for the clinical improvements observed in plasma‐mediated percutaneous discectomy studies, namely, biochemical instead of biomechanical mechanisms [48]. Preclinical studies have lent credibility to this argument by demonstrating that plasma‐mediated percutaneous discectomy creates a shift in cytokine expression that can reduce inflammation and promote healing [49,50]. The current study lends further support to this theory by demonstrating radiographic changes that are potential anatomic reflections of these cellular mechanisms.…”

Section: Discussionsupporting

confidence: 56%

A Quantitative Study of Intervertebral Disc Morphologic Changes Following Plasma-Mediated Percutaneous Discectomy

et al. 2014

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The short-term effects of electrosurgical ablation on proinflammatory mediator production by intervertebral disc cells in tissue culture

Cited by 14 publications

References 40 publications

Effect on Pain Relief and Inflammatory Response Following Addition of Tenoxicam to Intravenous Patient-Controlled Morphine Analgesia: A Double-Blind, Randomized, Controlled Study in Patients Undergoing Spine Fusion Surgery

Effect on Pain Relief and Inflammatory Response Following Addition of Tenoxicam to Intravenous Patient-Controlled Morphine Analgesia: A Double-Blind, Randomized, Controlled Study in Patients Undergoing Spine Fusion Surgery

Cytokine Antagonism Reduces Pain and Modulates Spinal Astrocytic Reactivity After Cervical Nerve Root Compression

A Quantitative Study of Intervertebral Disc Morphologic Changes Following Plasma-Mediated Percutaneous Discectomy

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