Effect on Pain Relief and Inflammatory Response Following Addition of Tenoxicam to Intravenous Patient-Controlled Morphine Analgesia: A Double-Blind, Randomized, Controlled Study in Patients Undergoing Spine Fusion Surgery

Chang, Wen-Kuei; Wu, Hsin-Lun; Yang, Chang-Sue; Chang, Kuang-Yi; Liu, Chien-Lin; Chan, Kwok-Hon; Sung, Chun-Sung

doi:10.1111/pme.12067

Cited by 20 publications

(14 citation statements)

References 43 publications

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“…It was shown that itch is blocked by certain NSAIDs such as tenoxicam and diclofenac, in humans (Colbert et al 1999, Chang et al 2013). The effect of prostaglandins (PGs) on pruritus has also been researched in further studies including both human (Neisius et al 2002) and rodents (Andoh andKuraishi 1998, Takaoka et al 2007).…”

Section: Discussionmentioning

confidence: 99%

The false-positive responses of analgesic drugs to the intradermal serotonin- and compound 48/80-induced scratches as an animal model of itch

İlkaya¹,

Yeşilyurt²,

Seyrek³

et al. 2016

Acta Neurobiologiae Experimentalis

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Intradermal injection of pruritogens such as serotonin, histamine and compound 48/80 into the skin and then, the evaluation of the scratching behavior is the commonly used animal model to advance pruritic research and drug development. However, predictive validity of this model is poorly documented. There is a close interaction between itch and pain sensations with regard to mediation through an anatomically and functionally identical neuronal pathway. One approach is whether the existing animal model of itch differentiates itch or pain to show efficacy of clinically effective analgesic drugs as a back translation. In this study, we explored the effects of different group of analgesic drugs on serotonin and compound 48/80-induced scratching behavior in Balb-C mice. Serotonin (25 μg) and compound 48/80 (100 μg) was injected intradermally in a volume of 50 μl into the rostral part of skin on the back of male mice and scratches were counted for a 30-min observation period. Morphine (1, 3, 10 mg/kg), tramadol (20, 40, 80 mg/kg), cannabinoid agonist CP 55,940 (0.1, 0.3, 1 mg/kg), paracetamol (100, 200, 300 mg/kg) and diclofenac (50, 100, 200 mg/kg) were given intraperitoneally 30 min prior to pruritogen injection. The analgesic drugs dose dependently blocked serotonin and compound 48/80-induced straching behavior with exerting complete inhibition at certain doses. Our data suggests that intradermal pruritogen-induced scratching models may not discriminate pain and itch sensations and give false positive results when standard analgesic drugs are used.

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Section: Discussionmentioning

confidence: 99%

The false-positive responses of analgesic drugs to the intradermal serotonin- and compound 48/80-induced scratches as an animal model of itch

İlkaya¹,

Yeşilyurt²,

Seyrek³

et al. 2016

Acta Neurobiologiae Experimentalis

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“…), in postoperative pain management (decreasing morphine consumption) [13], in renal colic [14] and in dentistry in postendodontic pain [15], providing also a prophylactic anti-inflammatory effect. In combination with other analgesics (morphine), it has been investigated for its additive antinociceptive effect in postoperative intravenous patient-controlled analgesia [16]. …”

Section: Introductionmentioning

confidence: 99%

Synergic Effects of Pregabalin-Acetaminophen Combination in Somatic and Visceral Nociceptive Reactivity

Mititelu-Tarțău

Popa²,

Lupușoru³

et al. 2014

Pharmacology

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Background/Aims: The present study investigates the effects of pregabalin (PGB), acetaminophen (ACET) and tenoxicam (TNX) administration in somatic and visceral nociception, using the tail flick test and the writhing test in mice. Methods: In the tail flick test, the substances were administered orally and the latency time response was recorded 15, 30, 60, 90 and 120 min after administration. In the writhing test, pain responses were scored every 5 min during a 30-min period after intraperitoneal injection of diluted acetic acid. Results: Our study demonstrated that oral administration of the combination PGB-ACET resulted in a stronger increase of latency reaction - statistically significant after 15 min compared to TNX and after 30 min compared to PGB in tail flick test. In the writhing test, the combination PGB-ACET, but also PGB-TNX, resulted in a stronger decrease of writhe numbers - statistically significant compared to the effects of the separate administration of each substance. This decrease was more intense in animals treated with the combination PGB-ACET than with PGB-TNX. Conclusion: These results suggest an antinociceptive activity which may be a consequence of the synergic action of the substances.

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“…The 2 RCTs that tested paracetamol found that it was more effective than placebo and less effective than dexketoprofen in reducing pain scores . The RCTs that tested systemic lidocaine, ketorolac, and NSAIDs (tenoxicam) led to controversial results . Upton et al found that fentanyl administered while maintaining an Analgesia Nociception Index of > 50 with boluses of 50 μg (in patients < 50 years of age) or 25 μg (in patients > 50 years of age) was more effective than the “classic” administration …”

Section: Resultsmentioning

confidence: 99%

“…The 29 RTCs that tested therapies administered during the intraoperative period included systemic pharmacological therapies (19 studies) [48][49][50][51][52][53][54][55][56][57][58][59][60][61][62][63][64][65][66] and locoregional anesthetic drugs (10 studies) [67][68][69][70][71][72][73][74][75][76] (see Table 3).…”

Section: Intraoperative Therapiesmentioning

confidence: 99%

Prevention and Treatment of Postoperative Pain after Lumbar Spine Procedures: A Systematic Review

et al. 2018

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Clinical evidence on perioperative pain management in patients undergoing spine procedures have significantly evolved after the review published in 2012. The aim of this systematic review was to report the latest evidence published. These include the preoperative use of dexamethasone, which was shown to be able to reduce pain at mobilization but not to reduce pain at rest or total morphine consumption; the use of gabapentinoids as part of a multimodal analgesic approach; and the safety and effectiveness of the intraoperative use of ketamine, dexketoprofen, and tramadol. Finally, electrical nerve stimulation is gaining interest and is potentially suitable for clinical needs.

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Effect on Pain Relief and Inflammatory Response Following Addition of Tenoxicam to Intravenous Patient-Controlled Morphine Analgesia: A Double-Blind, Randomized, Controlled Study in Patients Undergoing Spine Fusion Surgery

Cited by 20 publications

References 43 publications

The false-positive responses of analgesic drugs to the intradermal serotonin- and compound 48/80-induced scratches as an animal model of itch

The false-positive responses of analgesic drugs to the intradermal serotonin- and compound 48/80-induced scratches as an animal model of itch

Synergic Effects of Pregabalin-Acetaminophen Combination in Somatic and Visceral Nociceptive Reactivity

Prevention and Treatment of Postoperative Pain after Lumbar Spine Procedures: A Systematic Review

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