The short-term effects of analgesics on the kidney with special reference to acetylsalicylic acid

Arnold, L.; Collins, Catherine; Starmer, G. A.

doi:10.3109/00313027309060827

Cited by 28 publications

(5 citation statements)

References 14 publications

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“…The results confirm the findings of others that aspirin can cause acute damage to the tubular epithelium of the rat kidney (Calder et al, 1971 ;Arnold et al, 1973). Regeneration appears to take place rapidly in spite of the continued administration of aspirin and there is no evidence that this effect is related to the subsequent development of RPN.…”

Section: Light Microscopysupporting

confidence: 90%

Aspirin damage in the rat kidney in the intact animal and after unilateral nephrectomy

Molland¹

1976

The Journal of Pathology

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Section: Light Microscopysupporting

confidence: 90%

Aspirin damage in the rat kidney in the intact animal and after unilateral nephrectomy

Molland¹

1976

The Journal of Pathology

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“…'8"9 Pathological studies in the rat, however, suggest that tubular necrosis is transient despite continued dosing. 20 Although aspirin has been implicated in chronic analgesic nephropathy recent studies have cast doubt on this association.2'22 Moreover, high dose para-aminosalicylic acid (4-ASA) was, for many years, used in the treatment of tuberculosis yet nephrotoxic reactions were uncommon. In massive dose, however, 4-ASA may cause haematuria and reduce creatinine clearance, particularly in patients with preexisting renal disease.…”

Section: Discussionmentioning

confidence: 99%

Tests of renal function in patients with quiescent colitis: effects of drug treatment.

Riley

Lloyd

Mani

1992

Gut

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Mesalazine has structural similarities to aspirin and phenacetin and is nephrotoxic when given intravenously in high doses to rats. A number of cases of nephrotoxicity has been reported recently in patients taking oral mesalazine. Sensitive indicators of renal function in a group of patients maintained on long term, delayed release mesalazine and a comparable group on sulphasalazine have been studied. Sixty two patients (32 men, aged 28-82 years) with quiescent colitis were studied. Thirty four had been maintained on delayed release mesalazine 1-6 (0.8-2.4) g/day for 2-9 (0.5469) years and 28 on sulphasalazine 2 (2-3) g/day. Groups were comparable for age, sex, disease duration, and disease extent. Renal function was assessed by: urine microscopy; creatinine clearance; the urinary excretion of two markers of glomerular toxicity, albumin and transferrin; and the urinary excretion for two markers of tubular toxicity, N-acetyl-P-D-glucosaminidase (NAG) and almicroglobulin. There were no significant differences in renal function between the two treatment groups. Furthermore, no correlations were found between measures of renal function and either cumulative mesalazine dose or mesalazine treatment duration. In this study, long term maintenance treatment with delayed release mesalazine was no more nephrotoxic than continued treatment with sulphasalazine. (Gut 1992; 33: 1348-1352 The effect of mesalazine treatment on renal function has been a particular concern as mesalazine has structural similarities to aspirin and phenacetin, both of which have been implicated in analgesic nephropathy.3 Chronic sulphasalazine treatment does not seem to be nephrotoxic but the systemic absorption of 5-ASA from sulphasalazine is relatively low.4 Delayed release mesalazine formulations release their contents rapidly in the distal small intestine and proximal colon. Plasma concentrations of 5-ASA may therefore be higher in patients taking delayed release mesalazine than in patients taking equivalent doses of sulphasalazine.' In addition, freedom from sulphapyridine related side effects allows high dose treatment, further increasing the potential for dose related nephrotoxicity. We have therefore studied sensitive indicators of renal function in patients maintained on long term, delayed release mesalazine and a comparable group maintained on sulphasalazine. Methods PATIENT SELECTION AND ASSESSMENTPatients were selected from a computerised database of 222 patients with chronic ulcerative colitis attending Leigh Infirmary. Of these, 44 had been taking delayed release mesalazine as the sole maintenance treatment for at least six months. For each patient taking mesalazine a computer matched patient taking sulphasalazine was also selected. All pairs were matched for age. (within five years), sex, disease duration (within five years), and disease extent.Patients were invited to participate by letter and those who consented attended for outpatient review. Patients with symptoms of active colitis in the four weeks before attendance and t...

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“…A report [2] confirmed the non compliance of manufactured drugs found in Nigerian market with a study of 27 different drug samples collected from Lagos and Abuja. The regulatory agency NAFDAC, has been making concerted efforts at fighting the incidence of fake and adulterated drugs manufactured or imported into the country since 1993.…”

Section: Introductionmentioning

confidence: 61%

Comparative Chromatographic and Spectrophotometric Methods for Quantitative Estimation of Paracetamol in Analgesic Tablet Dosage Forms

Itodo¹,

Onyinye²

2017

SJAC

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Poor quality drugs pose a challenge to many countries especially the developing countries. This present study is a scientific approach to further combat medicines counterfeiting as well as the validation of claimed drug specification on labels. This was achieved by comparing two analytical methods viz; spectrophotometric (UV-Vis) and Chromatographic (HPLC) techniques for quantification of Paracetamol (4-acetamidophenol) in selected analgesics marketed in Lafia, Nigeria. The statistical validation parameters such as linearity and methodic error (accuracy, precision) tests were verified and reported in terms of deviation and significance. The tagged 500 mg/tab Paracetamol concentrations for procured Para-P, X, Y and Z were estimated to range between 505.62-570.70 mg/tab and 459.42-512.58 mg/tab using UV-Visible and HPLC respectively. It was reported that experimental paracetamol concentration compares well with the claimed label specification and are within limits prescribed by existing legislation. From results in this study, deviations in API's concentration values between the two techniques are reasonable but of no statistical significance.

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The short-term effects of analgesics on the kidney with special reference to acetylsalicylic acid

Cited by 28 publications

References 14 publications

Aspirin damage in the rat kidney in the intact animal and after unilateral nephrectomy

Aspirin damage in the rat kidney in the intact animal and after unilateral nephrectomy

Tests of renal function in patients with quiescent colitis: effects of drug treatment.

Comparative Chromatographic and Spectrophotometric Methods for Quantitative Estimation of Paracetamol in Analgesic Tablet Dosage Forms

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