The Serum Cholesterol Depressive Effect of Linoleic, Linolenic Acids and of Cod Liver Oil in Experimental Hypercholesterolacmic Rats

Jg, Hauge; Nicolaysen, R

doi:10.1111/j.1748-1716.1959.tb01675.x

Cited by 25 publications

(2 citation statements)

References 5 publications

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“…75 Rats have been fed sardine oil, 76 cuttlefish liver oil, 77 cod liver oil, 78 and tuna and menhaden oil. 7 9 8 0 In the latter studies, the highly unsaturated co-3 fatty acids found in the fish oils were compared to the ethyl esters of linolenic, linoleic, palmitic, and oleic acids in hypercholesterolemic rats.…”

Section: Animal Studiesmentioning

confidence: 99%

Polyunsaturated fatty acids, hyperlipidemia, and thrombosis.

Goodnight¹,

Harris

Connor³

et al. 1982

Arteriosclerosis

654

150

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Section: Animal Studiesmentioning

confidence: 99%

Polyunsaturated fatty acids, hyperlipidemia, and thrombosis.

Goodnight¹,

Harris

Connor³

et al. 1982

Arteriosclerosis

654

150

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“…At present there is considerable interest in the nutritional properties of polyunsaturated fatty acids [1,2], particularly those n-3 poly unsaturated fatty acids of marine origin, where there is increasing evidence for their preventive role in the development of coro nary heart disease in man [3,4], In studies in either experimental animals or man, various fish oil diets have been reported to alter blood pressure [5,6], lower serum cholesterol levels [7], increase bleeding time [8], reduce platelet aggregation [9], and prevent exper imental myocardial infarction [10]. Many of the effects are thought [3] to be mediated by the long-chain metabolites of a-linolenic acid (18:3,n-3) which include eicosapentaenoic acid (20:5,n-3), docosapentaenoic acid (22:5,n-3), and docosahexaenoic acid (22:6, n-3).…”

Section: Introductionmentioning

confidence: 99%

Altered Levels of n-6/n-3 Fatty Acids in Rat Heart and Storage Fat following Variable Dietary Intake of Linoleic Acid

et al. 1985

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Fat-supplemented diets enriched with linoleic acid by the addition of 12% w/w sunflower seed oil or proportionally reduced in linoleic acid by addition of 12% mutton fat were fed to rats for 18 months before the fatty acid composition of perirenal storage fat and myocardial membranes (phospholipids) was determined. Although the fatty acid composition of perirenal fat generally reflected that of the diet, there was an inverse relationship between the consumption of n-6 and the deposition of n-9 fatty acids. In addition, enhanced deposition of oleic acid (18:l, n-9) appears to be related to the dietary intake of stearic acid (18:0). In contrast, in myocardial membranes the n-3 polyunsaturated fatty acids are found to be increased when the intake of n-6 polyunsaturated fatty acids is reduced. This is particularly evident for docosahexaenoic acid (22:6, n-3) which is significantly increased in phosphatidylcholine, phosphatidylethanolamine, and diphosphatidylgycerol fractions of myocardial membranes, when the mutton fat diet was fed. After feeding the sunflower seed oil diet, the increased consumption of linoleic acid produced only small changes in the 18:2, n-6 content of cardiac phosphatidylcholine and phosphatidylethanolamine. These major classes of membrane phospholipids also showed only small increases in 20:4, n-6. In diphosphatidylglycerol, increased 18:2, n-6 also followed increased dietary intake, but this was not accompanied by increased 20:4, n-6. These changes in myocardial phospholipid fatty acid composition are similar to those observed after short-term feeding reported previously and confirm that changes in dietary n-6/n-3 fatty acid intake affect the fatty acid composition of both myocardial membranes and storage fat. These changes persist for the duration of the feeding period.

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Der Einfluß eines an essentiellen Fettsäuren reichen Triglyceridgemisches auf die Cholesteringehalte von Blut, Leber und Gehirn der Ratte

Brüggemann¹,

Niesar²,

Zentz³

1963

Nahrung

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In einem Literaturüberblick wird auf den Zusammenhang von Cholesterin‐ bzw. Lipoidstoffwechsel und atheromatösen Gefäßerkrankungen eingegangen. Versuche mit weiblichen Albinoratten zeigen, daß unter dem Einfluß eines an essentiellen Fettsäuren reichen Triglyceridgemisches (“Anticholestan”) der Cholesterin‐Blutspiegel bei einer Hypercholesterinämie erzeugenden Diät auf die Normalwerte gesenkt wird. Gleichzeitig wird durch “Anticholestan” der Cholesteringehalt der Leber sowohl bei der genannten Diät als auch bei Kontrolltieren erhöht, während die Werte für Gehirn konstant bleiben. Anhand der Versuchsergebnisse wird der Wirkungsmechanismus der ungesättigten Fettsäuren auf den Cholesterinstoffwechsel diskutiert.

show abstract

The Serum Cholesterol Depressive Effect of Linoleic, Linolenic Acids and of Cod Liver Oil in Experimental Hypercholesterolacmic Rats

Cited by 25 publications

References 5 publications

Polyunsaturated fatty acids, hyperlipidemia, and thrombosis.

Polyunsaturated fatty acids, hyperlipidemia, and thrombosis.

Altered Levels of n-6/n-3 Fatty Acids in Rat Heart and Storage Fat following Variable Dietary Intake of Linoleic Acid

Der Einfluß eines an essentiellen Fettsäuren reichen Triglyceridgemisches auf die Cholesteringehalte von Blut, Leber und Gehirn der Ratte

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