The seropervelance of infectious hepatitis viruses (HBV, HCV and HEV) among blood donors and their correlation to risk factors in Qena governorate, Upper Egypt

Ahmed, Azza Masoud Abdelbaky; Temerk, Hanan; Galal, Hamdi Ramdan; Bazeed, Shamardan Ezzeldin S.; Sultan, Serageldeen

doi:10.1007/s13337-020-00589-9

Cited by 6 publications

(10 citation statements)

References 31 publications

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“…The parenteral transmission of HEV after blood transfusion has already been documented 194,195 . The prevalence of anti‐HEV‐IgG in Egyptian blood donors ranged from 20.9% to 45.2% 196–198 . Indeed, the detection rate of anti‐HEV‐IgM and HEV RNA was 0.45%–5% 190,199 and 3% 190 among the Egyptian blood donors, respectively (Figure 3b,c).…”

Section: Hepatitis E Virusmentioning

confidence: 79%

Current situation of viral hepatitis in Egypt

Elbahrawy

Ibrahim

Eliwa

et al. 2021

Microbiology and Immunology

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An estimated 8–10 million people suffer from viral hepatitis in Egypt. Hepatitis A virus (HAV) and hepatitis E virus (HEV) are the major causes of viral hepatitis in Egypt as 50% or more of the Egyptian population are already exposed to HAV infection by the age of 15. In addition, over 60% of the Egyptian population test seropositive for anti‐HEV in the first decade of life. HEV mainly causes self‐limiting hepatitis; however, cases of fulminant hepatitis and liver failure were reported in Egypt. Hepatitis B virus (HBV), hepatitis C virus (HCV), and hepatitis D virus (HDV) are the main causes of chronic hepatitis, liver cirrhosis, and liver cancer (hepatocellular carcinoma [HCC]) in Egypt. Globally, Egypt had the highest age‐standardized death rate due to cirrhosis from 1990 to 2017. The prevalence rate of HBV (1.3%–1.5%) has declined after national infantile immunization. Coinfection of HBV patients with HDV is common in Egypt because HDV antibodies (IgG) vary in range from 8.3% to 43% among total HBV patients. After the conduction of multiple national programs to control HCV infection, a lower rate of HCV prevalence (4.6%) was recently reported. Data about the incidence of HCV after treatment with direct antiviral agents (DAAs) are lacking. An HCC incidence of 29/1000/year in cirrhotic patients after DAA treatment is reported. A higher rate of infiltrative pattern among HCC patients after DAA treatment is also recognized. Viral hepatitis is one of the major public health concerns in Egypt that needs more attention and funding from health policymakers.

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Section: Hepatitis E Virusmentioning

confidence: 79%

Current situation of viral hepatitis in Egypt

Elbahrawy

Ibrahim

Eliwa

et al. 2021

Microbiology and Immunology

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“…This finding suggests that, though low viremia of HEV was present among the Egyptian blood donors, blood transfusion could be a potential source of infection for Egyptians. A recent study was performed on 11,604 blood samples from apparently healthy blood donors in Qena Governorate in Upper Egypt [57]. In this study, higher HEV seroprevalence (28.7%) was reported among HCV and HBV seropositive blood donors [57].…”

Section: Blood Transfusion and Hev Transmissionmentioning

confidence: 73%

“…Previously, most HEV seropositive subjects and HEV-infected patients were either asymptomatic or developed a mild self-limiting course [18,43,53,54]. However, recent studies showed that HEV was the cause of fatal fulminant hepatitis among Egyptians [21,56], with a high prevalence rate among blood donors with other endemic hepatotropic pathogens such as hepatitis B virus (HBV) and hepatitis C virus (HCV) [57]. Taking into consideration the high rate of viral hepatitis and death associated with liver diseases in Egypt, we assume that this pathogen is responsible for several infections and deaths among Egyptians.…”

Section: Introductionmentioning

confidence: 99%

Is Hepatitis E Virus a Neglected or Emerging Pathogen in Egypt?

Sayed

Abdelwahab

2022

Pathogens

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Though Egypt ranks among the top countries for viral hepatitis and death-related liver disease, Hepatitis E virus (HEV) is a neglected disease. Living in villages and rural communities with low sanitation, use of underground well water and contact with animals are the main risk factors for HEV infection. Domestic animals, especially ruminants and their edible products, are one source of infection. Contamination of water by either human or animal stools is the main route of infection. In addition, HEV either alone or in coinfection with other hepatotropic viruses has been recorded in Egyptian blood donors. HEV seropositivity among Egyptian villagers was 60–80%, especially in the first decade of life. Though HEV seropositivity is the highest among Egyptians, HEV infection is not routinely diagnosed in Egyptian hospitals. The initial manifestations of HEV among Egyptians is a subclinical infection, although progression to fulminant hepatic failure has been recorded. With the improvement in serological and molecular approaches and increasing research on HEV, it is becoming clear that HEV represents a threat for Egyptians and preventive measures should be considered to reduce the infection rate and possible complications.

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“…By title and abstract screening, 308 studies were selected and entered the full-text screening. Only 30 studies 3 – 5 , 8 – 10 , 12 – 15 , 24 , 26 – 44 were finally included in our meta-analysis after full-text screening (Fig. 1 ) with 193,621 included participants: 97,597 male and 96,024 female.…”

Section: Resultsmentioning

confidence: 99%

“…The salience of gender in positioning women at increased risk of exposure to HCV infection has been confirmed by some studies 3 – 6 , while others support the view that HCV infection appears to be prevalent and progresses more rapidly in males than in females 7 – 11 . On the other hand, some studies found gender differences are artifactual, with nearly flat rates of HCV infection 12 – 15 . Also, some studies found a decreased rate of liver cirrhosis and hepatocellular carcinoma (HCC) in females 16 , more progress to hepatic fibrosis in males, and more liability to adverse events of direct-acting antivirals (DAAs) in females 17 .…”

Section: Introductionmentioning

confidence: 99%

Gender differences in prevalence of hepatitis C virus infection in Egypt: a systematic review and meta-analysis

Abdel-Gawad

Nour

El-Raey

et al. 2023

Sci Rep

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Egypt is the country with the highest known hepatitis C virus (HCV) prevalence worldwide. The origin of gender differences in HCV prevalence is not usually well understood. This systematic review and meta-analysis aimed to review and evaluate the gender differences in HCV infection rates amongst Egyptians. Such data would be important to support prevention and control programs aiming to minimize HCV-related morbidity and mortality. PubMed, Scopus, and Web of Science (WOS) were searched for relevant articles published from 1st January 2011 to 13th December 2021, using the search terms (HCV OR “hepatitis C” OR hepacivirus) AND (prevalence OR seroprevalence OR epidemiology OR incidence OR magnitude). At first, retrieved articles were screened, and then relevant data were extracted and analyzed. Descriptive statistics were used for data analysis. Out of 616 studies from databases, only 30 were included after the full-text screening, with 193,621 included participants: 97,597 male and 96,024 female. The overall seroprevalence of HCV antibodies in all included studies was 0.02 (CI − 0.23 to 0.28), with no significant difference between males and females. However, HCV RNA positivity was significantly more prevalent in males than females in adults and the general population (after excluding high-risk groups). In children, no statistically significant differences between males and females were found in the seroprevalence of HCV antibodies nor in the prevalence of PCR positivity. HCV RNA positivity is significantly higher in males than females in adults, while there are no gender differences in children.

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The seropervelance of infectious hepatitis viruses (HBV, HCV and HEV) among blood donors and their correlation to risk factors in Qena governorate, Upper Egypt

Cited by 6 publications

References 31 publications

Current situation of viral hepatitis in Egypt

Current situation of viral hepatitis in Egypt

Is Hepatitis E Virus a Neglected or Emerging Pathogen in Egypt?

Gender differences in prevalence of hepatitis C virus infection in Egypt: a systematic review and meta-analysis

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