The sensitizing capacity of atranorin

Abstract

The allergenic potential of the aromatic lichen substance atranorin has been investigated by means of the guinea pig maximization test of Magnusson & Kligman. Sensitivity was induced in 30% of the animals, which corresponds to a moderate allergenic capacity (grade III). This is in agreement with the clinically-observed frequency of 1.5% among our patients. A modified photoallergy test on the same animals was performed, but irradiation did not increase the number of positive reactions. 4 patients with proven contact sensitivity to atranorin, evernic, usnic or physodic acid, were examined with different dilutions from 0.001 to 0.1%. Irradiation of the test series did not provoke any clear-cut photoallergic reaction.

Chemical constituents from Ouratea floribunda: complete¹H and 13C NMR assignments of atranorin and its new acetyl derivative

“…Atranorin is a para-β-orcinol depside bearing CO 2 Me, CHO and OH groups, frequently found in lichens, it seems that the wood of O. floribunda used in this study was contaminated. Among the aromatic lichen compounds, atranorin is the most frequent allergenic agent responsible for airborne contact dermatitis 21,22 .…”

An investigation of the allergenic constituents of Cladonia stellaris (Opiz) Pous & VeŽda (‘silver moss’, ‘reindeer moss’ or ‘reindeer lichen’)

“…again and to determine the sensitizing potential of its raw extract and some of the more common lichen acids. As far as we could trace from the literature, no experimental sensitization trials have previously been performed with lichen acids and depsides, except the study of Sandberg & Thune (21).…”

Allergic contact dermatitis from a natural deodorant: A report of 4 cases associated with lichen acid mix allergy

“…Unlike usnic acid, atranorin has been reported to cause photosensitivity, 8 although reports of photo patch test results have been variable. 12 We did not patch test any of the patients described to atranorin.…”

“…4,7,13 Tenchio published the first report of allergic contact dermatitis attributable to lichens in 1948, in a woodcutter who developed a widespread dermatitis, most prominent in areas where lichen fragments accumulated under his clothing. 12 Champion 14 described a case of allergic contact dermatitis occurring in the wife of a forest worker, who was exposed to lichen from her husband's clothing. On patch testing, she reacted to the lichen on the bark of the tree but did not react to the wood itself.…”