The selective separation of (S)-amlodipine via a hollow fiber supported liquid membrane: Modeling and experimental verification

Selective Enantioseparation of Racemic Amlodipine by Biphasic Recognition Chiral Separation System

“…The highest enantioselectivity (α) was 8.38 at a pH of 5.0, as illustrated in Table 1. The results are in agreement with our previous reports (36)(37)(38)(39)(40). Therefore, pH 5.0 was considered to be an …”

“…The value of this knowledge is most important for the chemical and pharmaceutical engineering process such as the liquid membrane process and the hollow fiber supported liquid membrane process. This study used the same initial parameters as in our recent work (36)(37)(38)(39)(40) to confirm that the operating conditions such as the buffer pH in the aqueous phase, type of organic solvents, contact time, and concentration ratio of racemic compound to extractant could influence chiral extraction and enantioseparation efficiency. The parameters studied include the effect of extraction equilibrium time, the influence of different alkyl chains of tartaric acids, types of β-cyclodextrin (β-CD) derivatives, organic solvents, and buffer pH.…”

Optimization study on continuous separation of equol enantiomers using enantioselective liquid–liquid extraction in centrifugal contactor separators

“…In this paper, we report a new method using enantioselective liquid-liquid extraction (ELLE) [13][14][15] in centrifugal contactor separator, which has excellent throughput/hold-up ratio, and good mass transfer characteristics due to fast mixing and separation [16][17][18]. As we all known, multistage extraction can give much higher efficiency than the single-stage.…”

Studies on multistage enantioselective liquid–liquid extraction of amino-(4-nitro-phenyl)-acetic acid enantiomers using CuPF6{(S)-BINAP}: Experiments and modeling

“…Examples can be found in area of the separation of enantiomers of amino acid, amine, amino alcohol and so on to obtain enantiomer drugs [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30]. However, most researchers devote to study the extraction equilibrium and the synthesis of new chiral selectors [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27].…”

“…So, it is necessary to gain new more efficient chiral separation methods. Enantioselective liquid-liquid extraction (ELLE) provides an attractive alternative to fulfill the need, which is expected to be cheaper and easier to scale up to commercial scale and has a wide range of application [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30].…”