Studies on multistage enantioselective liquid–liquid extraction of amino-(4-nitro-phenyl)-acetic acid enantiomers using CuPF6{(S)-BINAP}: Experiments and modeling

Tang, Kewen; Pan, Wanling; Huang, Yan Yan Shery

doi:10.1016/j.seppur.2014.07.031

Cited by 14 publications

(16 citation statements)

References 37 publications

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“…The change of ee and Y with the change of pH is because of the shift of the association-dissociation equilibrium of the enantiomers [21][22][23]. It is shown in Fig.…”

Section: Influence Of the Ph Value Of Aqueous Phasementioning

confidence: 95%

“…EQU is a very weakly acidic compound with pK a of 9.94. When pH in the range from 3 to 8, raising of pH has very little influence on the existence state of EQU and the amount of molecular species keep nearly unchanged [21][22][23]. So the ee and Y in both exit stream are keep constant at the explored range of pH.…”

Section: Influence Of the Ph Value Of Aqueous Phasementioning

confidence: 96%

“…The ee extract is equal to 0 at extractant concentration of 0 because the extract phase possesses no enantioselective ability, and EQU enantiomers is almost insoluble in aqueous phase without extractant. The increase of ee extract is due to the enhancement of enantioselectivity with the increase of extractant concentration [21][22][23]29,30]. With the further increase of extractant concentration, the extractant is present in excess with respect to the desired enantiomer and the undesired enantiomer will also be extracted in considerable amount, which will lead to the drop in the ee extract .…”

Section: Influence Of Extractant Concentrationmentioning

confidence: 99%

“…Therefore, the multistage extraction should be studied. As for other separators, we have described some methods in detail in the introduction section, such as chiral HPLC, and given up these methods due to their disadvantage in the production scale.We have applied this method to several drugs and good efficiency is obtained [16,[20][21][22][23]. Hydroxypropyl-␤-cyclodextrin (HP-␤-CD, Fig.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Optimization study on continuous separation of equol enantiomers using enantioselective liquid–liquid extraction in centrifugal contactor separators

Tang

Wang

Zhang

et al. 2016

Process Biochemistry

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“…The change of ee and Y with the change of pH is because of the shift of the association-dissociation equilibrium of the enantiomers [21][22][23]. It is shown in Fig.…”

Section: Influence Of the Ph Value Of Aqueous Phasementioning

confidence: 95%

Section: Influence Of the Ph Value Of Aqueous Phasementioning

confidence: 96%

Section: Influence Of Extractant Concentrationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Optimization study on continuous separation of equol enantiomers using enantioselective liquid–liquid extraction in centrifugal contactor separators

Tang

Wang

Zhang

et al. 2016

Process Biochemistry

Self Cite

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“…1,2 Tartaric acid, 3 crown ether, 4 cyclodextrin, 5 cinchona alkaloid, 6 and metal complex 7 are common chiral extractants that are widely used in enantioselective liquid-liquid extractions. 7,[16][17][18][19][20][21][22] And our precious works also revealed that (S)-MeO-BIPHEP and (S)-SEGPHOS have good abilities to recognize amino acid enantiomers. (S)-BINAP, (S)-MeO-BIPHEP, and (S)-SEGPHOS are important chiral catalysts that are widely used in asymmetric reactions.…”

Section: Introductionmentioning

confidence: 93%

Enantioselective liquid‐liquid extraction of DL‐mandelic acid using chiral diphosphine ligands as extractants

Liu

Zhou

et al. 2019

Chirality

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In order to expand the application range of chiral diphosphine ligands, (S)-BINAP, (S)-SEGPHOS, and (S)-MeO-BIPHEP were employed as extractants to recognize DL-mandelic acid. The results indicated that (S)-SEGPHOS-Cu exhibited considerable ability to recognize DL-mandelic acid with operational enantioselectivity (α) of 2.677. The process of extraction of DL-mandelic acid using (S)-SEGPHOS-Cu as extractant was systematically investigated. Performance factor (pf) was adopted to comprehensively evaluate the extraction. After optimization by response surface methodology (RSM), the optimal extraction condition is temperature of 5.5°C, (S)-SEGPHOS-Cu concentration of 3.0 mmol/L, and pH of 8.0. And the predicted and experimental maximum values of pf were 0.26374 and 0.26839, respectively. KEYWORDS (S)-BINAP, (S)-MeO-BIPHEP, (S)-SEGPHOS, enantioselective liquid-liquid extraction, mandelic acid

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Liquid‐Liquid Centrifugal Extractors: Types and Recent Applications – a Review

Hamamah

Grützner

2022

ChemBioEng Reviews

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In light of the elevating pressures toward adopting intensifying technologies, centrifugal extractors are increasingly drawing attention as a promising alternative to traditional extraction equipment. Recently, many fields have applied them in research and that resulted in a considerable amount of information that may be hard to follow. To keep interested researchers updated, this work presents the state‐of‐the‐art status of those devices. That is, the different types of centrifugal extractors are first surveyed with emphasis on those available on the market nowadays. Then, their recent applications are covered with exclusion of two fields: oil‐water separations and nuclear industry, as the purpose is to accent centrifugal extractors' potential and compatibility with the widest possible range of applications beyond traditional ones. A further section addresses the hydrodynamics of annular centrifugal contactors that form a major subfamily of centrifugal extractors. Those annular variants have received special focus throughout this work, since not only are they the most encountered devices in literature but also still to date under development with latest versions being 3D‐printed.

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Studies on multistage enantioselective liquid–liquid extraction of amino-(4-nitro-phenyl)-acetic acid enantiomers using CuPF6{(S)-BINAP}: Experiments and modeling

Cited by 14 publications

References 37 publications

Optimization study on continuous separation of equol enantiomers using enantioselective liquid–liquid extraction in centrifugal contactor separators

Optimization study on continuous separation of equol enantiomers using enantioselective liquid–liquid extraction in centrifugal contactor separators

Enantioselective liquid‐liquid extraction of DL‐mandelic acid using chiral diphosphine ligands as extractants

Liquid‐Liquid Centrifugal Extractors: Types and Recent Applications – a Review

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