Selective Enantioseparation of Racemic Amlodipine by Biphasic Recognition Chiral Separation System

Sunsandee, Niti; Rashatasakhon, Paitoon; Ramakul, Prakorn; Pancharoen, Ura; Nootong, Kasidit; Leepipatpiboon, Natchanun

doi:10.1080/01496395.2014.882356

Cited by 10 publications

(9 citation statements)

References 47 publications

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“…Accepted Article derivatives all require to be handled at frigid temperature, 10,11 which brings about intensive energy consumption. As far as we know, enantioselectivities of those methods near room temperature (298.15 K) would not be higher than 1.14.…”

Section: Influence Of Temperature On the Enantioselective Extractionmentioning

confidence: 99%

Quantum chemistry calculation aided design of chiral ionic liquid‐based extraction system for amlodipine separation

Ding

Chen

et al. 2018

AIChE Journal

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Amlodipine is a widely used medication in treating hypertension, which is also known as a chiral compound. So far efforts have been made to obtain optically pure (S)‐amlodipine because (R)‐amlodipine has poor efficacy and is related to undesirable side effects. However, the available separation methods for amlodipine are still unsatisfactory. Recently, chiral separation has become a promising application of chiral ionic liquids (CILs), because the structural designability enables them adjustable separation efficiency for specific tasks. In this work, a high‐efficient CIL‐based liquid–liquid extraction system was developed for racemic amlodipine separation with the assistance of quantum chemistry calculations. Enantioselectivity up to 1.35 achieved by the novel system at 298.15 K is significantly higher than other available extraction systems. Moreover, the recycling of CIL can be easily realized by backward extraction of amlodipine, which is important for the industrial application of CILs. © 2018 American Institute of Chemical Engineers AIChE J, 64: 4080–4088, 2018

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Section: Influence Of Temperature On the Enantioselective Extractionmentioning

confidence: 99%

Quantum chemistry calculation aided design of chiral ionic liquid‐based extraction system for amlodipine separation

Ding

Chen

et al. 2018

AIChE Journal

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“…Liu et al did biphasic recognition chiral extraction of pantoprazole enantiomers; they used β-cyclodextrin and tartaric acid as chiral selectors [24]. Sunsandee et al experiment enantioseparation of racemic amlodipine by biphasic recognition chiral separation system [25].…”

Section: Biphasic Recognition Chiral Extractionmentioning

confidence: 99%

Recent Development: Enantio Selective Eextraction in Chiral Separation

Hadjmohammadi¹,

Majidhashemi²

2021

austinchromatogrl

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This paper discusses the recent development of enantioselective extraction methods. There are several methods in this field. The principles of all of enantioselective extraction methods are presented a focus on twophase extractions, in these methods used a chiral compound that named chiral selector, this compound distinguishes between two chiral isomers in complexation process, then one isomer more captured by chiral selector, and separation processes happen. The chiral selector should dissolve in on phase. In these methods, typical performance data are reported major emphasis on distribution ratio and enantioselectivity value or selectivity factor. In this paper, we introduce types of enantioselective extraction method, and discuss about them with several examples.

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“…Liu et al, did biphasic recognition chiral extraction of pantoprazole enantiomers, they used β-cyclodextrin and tartaric acid as chiral selectorsm [24]. Sunsandee et al, experiment enantioseparation of racemic amlodipine by biphasic recognition chiral separation system [25].…”

Section: Biphasic Recognition Chiral Extractionmentioning

confidence: 99%