The Screening of Antidiabetic Activity and The Cultivation Study of Local Marine Microalgae

Priatni, Sri; Ratnaningrum, Diah; Kosasih, Wawan

doi:10.1088/1757-899x/1011/1/012066

Cited by 6 publications

(4 citation statements)

References 9 publications

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“…and Porphyridium sp. were shown to potentially have α-glucosidase inhibition, with a percentage of 12.55 and 12.63% [ 64 ]. All lichen photobiont extracts showed inhibitory effects superior to those described above, reinforcing that they possessed moderate α-glycosidase inhibitory activity.…”

Section: Resultsmentioning

confidence: 99%

Isolation and Identification of Lichen Photobionts Collected from Different Environments in North of Portugal and Evaluation of Bioactivities of Their Extracts

Loureiro,

Morais,

Silva

et al. 2024

Foods

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Lichens are organisms constituted by a symbiotic relationship between a fungus (mycobiont) and a photoautotrophic partner (photobiont). Lichens produce several bioactive compounds; however, the biotechnological exploitation of this organism is hampered by its slow growth. To start studying the possibility of exploiting lichens as alternative sources of bioactive compounds, eighteen lichens were collected in the north of Portugal in order to isolate and study the bioactivity of their photobionts. It was possible to isolate and cultivate only eight photobionts. Three of them, LFR1, LFA2 and LCF3, belong to the Coelastrella genus, the other two (LFA1 and LCF1) belong to the Chlorella genus and for the remaining three photobionts, LFS1, LCA1 and LCR1, it was impossible to isolate their microalgae. These only grow in consortium with bacteria and/or cyanobacteria. All extracts showed antioxidant activity, mainly at a concentration of 10 mg.mL−1. LFS1, a consortium extract, showed the highest antioxidant power, as well as the highest concentration of phenolic compounds (5.16 ± 0.53 mg of gallic acid equivalents (GAE).g−1). The extracts under study did not show significant antibacterial activity against Escherichia coli, Listeria or Salmonella. The Coelastrella sp. and LFA1 extracts showed the highest hyaluronidase inhibition. The LFR1 extract at a concentration of 5 mg.mL−1 showed the highest anti-inflammatory activity (79.77 ± 7.66%). The extracts of Coelastrella sp. and LFA1 also showed greater antidiabetic activity, demonstrating the high inhibitory power of α-amylase and α-glucosidase. LFR1 at a concentration of 5 mg.mL−1, due to its selective cytotoxicity inhibiting the growth of cancer cells (Caco-2 cells), is a promising anticancer agent.

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Section: Resultsmentioning

confidence: 99%

Isolation and Identification of Lichen Photobionts Collected from Different Environments in North of Portugal and Evaluation of Bioactivities of Their Extracts

Loureiro,

Morais,

Silva

et al. 2024

Foods

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“…The same extract was also found to have a strong α-glucosidase inhibitory activity of 97.42% and an IC50 value of 9.56 mg/mL compared to Acarbose standard drug, which recorded 1.03 mg/mL. Moreover the results of Priatni et al [94] showed that the methanolic extract of the marine microalgae Porphyridium sp. (Rhodophyta) is the best microalgae in the inhibiting of α-glucosidase enzyme with 12.63%.…”

Section: The Inhibitory Activity Of Algae On the Carbohydrate Hydroly...mentioning

confidence: 86%

Antioxidant and Antidiabetic Activity of Algae

Abo-Shady¹,

Gheda²,

Ismail³

et al. 2022

Preprint

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Currently, algae arouse a growing interest in the pharmaceutical and cosmetic area due to the fact that they have a great diversity of bioactive compounds with the potential for pharmacological, cosmetic, and nutraceutical applications. Many of these bioactive compounds are secondary metabolites whose amounts in the algae vary with varying environmental conditions. Free radicals and other active oxygen derivatives are recognized as a natural by-product of aerobic metabolism. However, reactive oxygen species directly participate in mechanisms related to various pathological states such as cancer, diabetes, atherosclerosis, Alzheimer's, and Parkinson's, among others. Diabetes mellitus (DM) is a metabolic disease resulting from changes in glucose metabolism and/or deficient production/action of insulin. This review has as its main objective to reveal the potential antioxidant and antidiabetic capacity of algae extracts.

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“…Moreover, the study by Priatni etal. [ 93 ] showed that the methanolic extract of the marine microalgae Porphyridium sp. (Rhodophyta) was the strongest among the studied microalgae in inhibiting the α-glucosidase enzyme activity (12.63%).…”

Section: Treatment Of Diabetesmentioning

confidence: 99%

Antioxidant and Antidiabetic Activity of Algae

Abo-Shady

Gheda

Ismail

et al. 2023

Life

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Currently, algae arouse a growing interest in the pharmaceutical and cosmetic area due to the fact that they have a great diversity of bioactive compounds with the potential for pharmacological and nutraceutical applications. Due to lifestyle modifications brought on by rapid urbanization, diabetes mellitus, a metabolic illness, is the third largest cause of death globally. The hunt for an efficient natural-based antidiabetic therapy is crucial to battling diabetes and the associated consequences due to the unfavorable side effects of currently available antidiabetic medications. Finding the possible advantages of algae for the control of diabetes is crucial for the creation of natural drugs. Many of algae’s metabolic processes produce bioactive secondary metabolites, which give algae their diverse chemical and biological features. Numerous studies have demonstrated the antioxidant and antidiabetic benefits of algae, mostly by blocking carbohydrate hydrolyzing enzyme activity, such as α-amylase and α-glucosidase. Additionally, bioactive components from algae can lessen diabetic symptoms in vivo. Therefore, the current review concentrates on the role of various secondary bioactive substances found naturally in algae and their potential as antioxidants and antidiabetic materials, as well as the urgent need to apply these substances in the pharmaceutical industry.

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The Screening of Antidiabetic Activity and The Cultivation Study of Local Marine Microalgae

Cited by 6 publications

References 9 publications

Isolation and Identification of Lichen Photobionts Collected from Different Environments in North of Portugal and Evaluation of Bioactivities of Their Extracts

Isolation and Identification of Lichen Photobionts Collected from Different Environments in North of Portugal and Evaluation of Bioactivities of Their Extracts

Antioxidant and Antidiabetic Activity of Algae

Antioxidant and Antidiabetic Activity of Algae

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