The safety, efficacy and pharmaceutical quality of male enhancement nutraceuticals bought online: Truth versus claim

Nounou, Mohamed Ismail; Eassa, Heba A.; Helal, Nada A; AboulFotouh, Khaled; Mansoor, Ihab; Latz, Isabel; Zheng, Cindy; Eassa, Hadeer A; Mohamed, Dina; Huynh, Diana; Wiss, Abigail; Sweeney, Jessica; Oakes, Monica T.; Mikhail, Mark; Amine, Nadine; Kaur, Harshvir; Echeverry, Natalia; Orzechowski, Kamila; Szollosi, Doreen E.

doi:10.1016/j.joim.2021.02.003

Cited by 6 publications

(3 citation statements)

References 29 publications

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“…Various male enhancement nutraceuticals are sold worldwide, and patients with ED often use these nutraceuticals [ 113 ]. However, their pharmacological mechanisms are not fully understood.…”

Section: Phosphodiesterase Type 5 Inhibitors and Macrophagesmentioning

confidence: 99%

“…However, their pharmacological mechanisms are not fully understood. In recent years, the safety, efficacy, and pharmacological quality of these nutraceutical products have been investigated using in vitro studies [ 113 ]. A variety of male enhancement nutraceuticals, such as Horny Goat Weed ® and AlphaMan XL ® , suppressed LPS-induced interleukin (IL)-6 production by murine macrophages (J744 cell) in a dose-dependent manner [ 113 ].…”

Section: Phosphodiesterase Type 5 Inhibitors and Macrophagesmentioning

confidence: 99%

“…In recent years, the safety, efficacy, and pharmacological quality of these nutraceutical products have been investigated using in vitro studies [ 113 ]. A variety of male enhancement nutraceuticals, such as Horny Goat Weed ® and AlphaMan XL ® , suppressed LPS-induced interleukin (IL)-6 production by murine macrophages (J744 cell) in a dose-dependent manner [ 113 ]. Thus, male enhancement products are speculated to have anti-inflammatory effects, and macrophages play important roles in such pharmacological activities.…”

Section: Phosphodiesterase Type 5 Inhibitors and Macrophagesmentioning

confidence: 99%

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Pathological Significance of Macrophages in Erectile Dysfunction Including Peyronie’s Disease

et al. 2021

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Erectile function is regulated by complex mechanisms centered on vascular- and nerve-related systems. Hence, dysregulation of these systems leads to erectile dysfunction (ED), which causes mental distress and decreases the quality of life of patients and their partners. At the molecular level, many factors, such as fibrosis, lipid metabolism abnormalities, the immune system, and stem cells, play crucial roles in the etiology and development of ED. Although phosphodiesterase type 5 (PDE5) inhibitors are currently the standard treatment agents for patients with ED, they are effective only in a subgroup of patients. Therefore, further insight into the pathological mechanism underlying ED is needed to discuss ED treatment strategies. In this review, we focused on the biological and pathological significance of macrophages in ED because the interaction of macrophages with ED-related mechanisms have not been well explored, despite their important roles in vasculogenic and neurogenic diseases. Furthermore, we examined the pathological significance of macrophages in Peyronie’s disease (PD), a cause of ED characterized by penile deformation (visible curvature) during erection and pain. Although microinjury and the subsequent abnormal healing process of the tunica albuginea are known to be important processes in this disease, the detailed etiology and pathophysiology of PD are not fully understood. This is the first review on the pathological role of macrophages in PD.

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Section: Phosphodiesterase Type 5 Inhibitors and Macrophagesmentioning

confidence: 99%

Section: Phosphodiesterase Type 5 Inhibitors and Macrophagesmentioning

confidence: 99%

Section: Phosphodiesterase Type 5 Inhibitors and Macrophagesmentioning

confidence: 99%

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Pathological Significance of Macrophages in Erectile Dysfunction Including Peyronie’s Disease

et al. 2021

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Halal Logo as Consumer Alternative Solution for Nutraceutical Products Issues

Shamsudin,

Abu Bakar,

Anuar Musaddad

et al. 2023

Contributions to Environmental Sciences &Amp; Innovative Business Technology

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Adulteration and Safety Issues in Nutraceuticals and Functional Foods

Egea

Filho

Gautério

et al. 2022

Biopolymers in Nutraceuticals and Functional Foods

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The search for foods capable of providing positive impacts on human health has grown in recent times due to the desire for more conscious and healthier lifestyles. In this sense, nutraceuticals and functional foods have been recognized for the various beneficial health effects associated with their ingestion, presenting several biological activities, including antioxidant, antimicrobial, antiviral, antifungal, anti-inflammatory, antimutagenic, antiobesity, anticholinesterase, and anticarcinogenic activities. As such they can play a potentially beneficial role in reducing the risk of chronic degenerative diseases, such as cancer and diabetes, among others. Despite the reported effects, there is no internationally accepted definition for these products and their respective labels, which leads to different regulations between countries and difficulties in market integration. Additionally, there are many counterfeit or adulterated products available, which pose a serious threat to the health of consumers. The most common inadequacies and problems are formulation adulteration, absence or insufficient amounts of the functional component, as well as traces of contamination by pesticides, herbicides, heavy metals, and adulterants. Accordingly, this chapter provides an overview of the adulteration and safety issues in nutraceuticals and functional foods around the world.

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The safety, efficacy and pharmaceutical quality of male enhancement nutraceuticals bought online: Truth versus claim

Cited by 6 publications

References 29 publications

Pathological Significance of Macrophages in Erectile Dysfunction Including Peyronie’s Disease

Pathological Significance of Macrophages in Erectile Dysfunction Including Peyronie’s Disease

Halal Logo as Consumer Alternative Solution for Nutraceutical Products Issues

Adulteration and Safety Issues in Nutraceuticals and Functional Foods

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