The safety and effectiveness of stepwise and low-dose administration of follicle stimulating hormone in WHO group II anovulatory infertile women: Evidence from a large multicenter study in Spain

Abstract

Stepwise and chronic low-dose administration of FSH is a safe and effective method for treatment of WHO group II anovulatory infertility, mainly in those patients having high LH/FSH ratios.

Consensus on infertility treatment related to polycystic ovary syndrome

“…Correspondingly, there is a low incidence of multiple pregnancies (<6%) and OHSS (<1%) (67,80,110,111). These results compare favorably to the unacceptable high risk of multiple follicular development, multiple pregnancies (36%), and severe OHSS (4.6%) reported for conventional dose protocols (112).…”

Strategies to reduce multiple pregnancies due to ovulation stimulation

“…The results of five recent studies with R500 cycles that used minimal stimulation with initial doses of 37.5-75 IU FSH or hMG for a combined total of 8,370 cycles are presented in Table 5 (49)(50)(51)(52)(53). Clinical pregnancy rates ranged from 10% to 20% per cycle, equal to or exceeding pregnancy rates reportedfrom recent large series of COH-IUI (9,39).…”

“…In modern series of R4,000 cycles or R1,800 pregnancies, twin implantations range from 15% to 20% and HOMP from 5.7% to 8.8% when the initial dose of FSH or hMG is 150 IU or greater (9,26,39). In series of R500 cycles using minimal stimulation initial doses of 37.5-75 IU FSH or hMG, twin implantations ranged from 6% to 15% and HOMP from 0 to 1.3% (49)(50)(51)(52)(53).…”

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“…In clomiphene failures, injectable gonadotropins remain a successful alternative (1). Several recent, large reports (4)(5)(6)(7)(8), including a multicenter study in 1058-0468/98/1000-0552$15.00/0 C 1998 Plenum Publishing Corporation 552 KEY WORDS: low-dose follicle-stimulating hormone (FSH) therapy; induction of ovulation; recombinant FSH; WHO group II anovulation.…”